2019
DOI: 10.1016/j.intimp.2019.03.039
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Dysfunctional microglia:neuron interactions with significant female bias in a developmental gene x environment rodent model of Alzheimer's disease

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Cited by 4 publications
(2 citation statements)
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“…Therefore, the broad M1 and M2 classification is still useful, as it exemplifies the dynamic microglial response to brain injuries and helps to understand the functional status of microglia (27). Emerging literature has reported changes in microglial M1-M2 phenotypes in various neuroinflammatory diseases, including Alzheimer's disease (34), multiple sclerosis (35), traumatic brain injury (36), and stroke (37), all of which indicate the importance of changes in microglial M1-M2 polarization and expand the potential importance of this study.…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, the broad M1 and M2 classification is still useful, as it exemplifies the dynamic microglial response to brain injuries and helps to understand the functional status of microglia (27). Emerging literature has reported changes in microglial M1-M2 phenotypes in various neuroinflammatory diseases, including Alzheimer's disease (34), multiple sclerosis (35), traumatic brain injury (36), and stroke (37), all of which indicate the importance of changes in microglial M1-M2 polarization and expand the potential importance of this study.…”
Section: Discussionmentioning
confidence: 99%
“…Expression from AAV particles injected at P0 is initiated soon after injection and peaks 1 week later. 64 Thus, similar to HD and early-onset Alzheimer's disease, [65][66][67][68][69][70][71][72] these data are consistent with XDP as a genetic, neurodegenerative disease in which molecular alterations occur early, but "classic" pathology and symptoms do not emerge until adult ages, suggesting that presymptomatic therapeutic intervention may be optimal.…”
Section: Discussionmentioning
confidence: 61%