Dysfunctions of brain oxytocin signaling: Implications for poor mothering

Sanson, Alice; Bosch, Oliver J.

doi:10.1016/j.neuropharm.2022.109049

Cited by 17 publications

(11 citation statements)

References 165 publications

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“…OXT is involved in the different phases of parturition and is considered an essential hormone to facilitate maternal bonds [ 80 ]. In several studies, disrupted brain OXT signaling is linked to poor mothering [ 81 ]. OXT evaluation can be performed in domestic animals through plasma, saliva, and milk [ 82 ].…”

Section: The Role Of Oxt In the Establishment Of Maternal Behavior Re...mentioning

confidence: 99%

The Role of Oxytocin in Domestic Animal’s Maternal Care: Parturition, Bonding, and Lactation

Mota-Rojas

Marcet-Rius

Domínguez-Oliva

et al. 2023

Animals

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Oxytocin (OXT) is one of the essential hormones in the birth process; however, estradiol, prolactin, cortisol, relaxin, connexin, and prostaglandin are also present. In addition to parturition, the functions in which OXT is also involved in mammals include the induction of maternal behavior, including imprinting and maternal care, social cognition, and affiliative behavior, which can affect allo-parental care. The present article aimed to analyze the role of OXT and the neurophysiologic regulation of this hormone during parturition, how it can promote or impair maternal behavior and bonding, and its importance in lactation in domestic animals.

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Section: The Role Of Oxt In the Establishment Of Maternal Behavior Re...mentioning

confidence: 99%

The Role of Oxytocin in Domestic Animal’s Maternal Care: Parturition, Bonding, and Lactation

Mota-Rojas

Marcet-Rius

Domínguez-Oliva

et al. 2023

Animals

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“…Die Möglichkeit zur Ausbildung stabiler Beziehungen im Erwachsenenalter ist nicht einfach gegeben, sondern wird maßgeblich durch frühe Beziehungserfahrungen beeinflusst und bleibt dann relativ stabil über das Leben erhalten [49,50]. Gleichermaßen programmieren die frühen Beziehungserfahrungen auf physiologischer Ebene das Oxytocinsystem, was wiederum Einfluss auf die spätere Beziehungsgestaltung hat [51,52]. Dies zeigt sich auch durch Befunde, welche eine Assoziation von Mutter-Kind-Interaktionen mit der Methylierung des Oxytocinrezeptorgens zeigen sowie der Assoziation zwischen Bindungsverhalten im Erwachsenenalter und der Methylierung des Oxytocinrezeptorgens [53][54][55].…”

Section: Oxytocin Und Bindungunclassified

“…Stress Modulation der HPA-Achse [18] Bindung Belohnung durch soziale Interaktion, Programmierung für spätere Interaktionen [44,48,52] Soziales und antisoziales Verhalten Vertrauen, Aggression, Lügen [3,62,63,67] Allostatische Prozesse Anpassung von Sollwerten, antizipatorische Prozesse [12] Dieses Dokument wurde zum persönlichen Gebrauch heruntergeladen. Vervielfältigung nur mit Zustimmung des Verlages.…”

Section: Funktionen Des Oxytocinsystems Beispiele Literaturunclassified

Die Rolle des Oxytocinsystems für die Entstehung der Depression

Sanwald¹,

Kammer²,

Montag³

et al. 2023

Nervenheilkunde

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ZUSAMMENFASSUNGOxytocin erregte aufgrund seiner Rolle für das menschliche Sozialverhalten in den letzten Jahren vermehrt Aufmerksamkeit hinsichtlich der Erforschung der Ätiologie depressiver Erkrankungen. Aktuelle Forschungsergebnisse legen die Komplexität des Oxytocinsystems und sowohl pro- als auch antisoziale Effekte des Neuropeptids offen, weshalb seine Rolle für die Salienz sozialer Reize oder allgemeiner für allostatische Prozesse diskutiert wird. Diese Arbeit fasst Befunde zu den Zusammenhängen zwischen Oxytocin und belastenden Lebensereignissen sowie zwischen Oxytocin und der Verstärkung sozialer Interaktionen zusammen. Ausgehend von diesen Verknüpfungen des Oxytocinsystems mit dem körperlichen Stresssystem und dem Belohnungssystem stellt diese Arbeit einen Versuch dar, aktuelle Theorien zur Funktion von Oxytocin auf die Depression anzuwenden, um so eine Hypothese zur Rolle des Oxytocinsystems hinsichtlich des Ursprungs der biologischen und behavioralen Korrelate dieser Störung aufzustellen.

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“…As mother’s brain is selectively wired to social moments (Shimon-Raz et al, 2021), our second hypothesis contended that the social contexts would elicit greater synchronization in the PCN as compared to contexts of mother or infant alone. Finally, as OT is a key modulator of the maternal brain (Panksepp et al, 1997; Marlin and Froemke, 2017; Sanson and Bosch, 2022), we hypothesized that OT would modulate cross-brain synchronization levels in postpartum mothers. In addition to these pre-registered hypotheses, we also examined whether modulations in behavioral synchrony during the free play vignette will be tracked by modulations in mothers’ cross-brain synchronization.…”

Section: Introductionmentioning

confidence: 99%

Attachment Stimuli Trigger Widespread Synchrony across Multiple Brains

Shimon-Raz

Yeshurun

Ulmer-Yaniv

et al. 2023

Preprint

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Infant stimuli elicit a widespread neural and behavioral response in human adults and such massive allocation of resources attests to the evolutionary significance of the primary attachment. Here, we examined whether attachment-related cues also trigger cross-brain concordance, generating greater neural uniformity among individuals. Post-partum mothers were imaged twice in oxytocin/placebo administration design and stimuli included four ecological videos; two of infant/mother alone (Alone) and two mother-infant dyadic contexts (Social). Theory-driven analysis measured cross-brain synchrony in preregistered nodes of the parental caregiving network (PCN), which integrates subcortical structures underpinning mammalian mothering with cortical areas implicated in simulation, mentalization, and emotion regulation, and data-driven analysis assessed brain-wide concordance using whole brain parcellation. Results demonstrated widespread cross-brain synchrony in both the PCN and across the neuroaxis, from primary sensory and somatosensory areas, through insular-cingulate regions, to temporal and prefrontal cortices. The Social context yielded significantly more cross-brain concordance, with PCN's striatum, parahipporcampal gyrus, superior temporal sulcus, anterior cingulate cortex (ACC), and prefrontal cortex displaying cross-brain synchrony only to mother-infant social cues. Moment-by-moment fluctuations in mother-infant social synchrony, ranging from episodes of gaze aversion to rhythmically-coordinated positive bouts, were tracked online by cross-brain concordance in the pre-registered ACC. Findings indicate that social attachment stimuli, representing evolutionary-salient universal cues that require no verbal narrative for immediate comprehension, trigger substantial inter-brain concordance and suggest that the mother-infant bond, an icon standing at the heart of human civilization, may function to glue brains into a unified experience and bind humans into social groups.

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Dysfunctions of brain oxytocin signaling: Implications for poor mothering

Cited by 17 publications

References 165 publications

The Role of Oxytocin in Domestic Animal’s Maternal Care: Parturition, Bonding, and Lactation

The Role of Oxytocin in Domestic Animal’s Maternal Care: Parturition, Bonding, and Lactation

Die Rolle des Oxytocinsystems für die Entstehung der Depression

Attachment Stimuli Trigger Widespread Synchrony across Multiple Brains

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