Dyshomeostasis of Serum Oxidant/Antioxidant Status and Copper, Zinc, and Selenium Levels in Elderly Physically Disabled Persons: an AHAP-Based Study

Abstract

The percentage of elderly persons is rapidly growing. Physical disability is one of the main age-related diseases which affect life quality. There are some studies that suggest the oxidative stress and trace elements are involved in physical disability in elderly persons, but the results are inconclusive. Therefore, the aim of this study was to investigate the status of aforementioned parameters in elderly physically disabled patients vs. healthy ones. According to the Katz questionnaire form, 44 subjects with physical disability and 66 age-gender-matched healthy subjects were selected from Amirkola Health and Aging Project (AHAP). The results indicated that patient group had lower serum Zn, Se, and total antioxidant levels than the control group (p < 0.001), whereas serum total oxidant level and Cu to Zn ratio (CZr) were higher in control group than in healthy one (p < 0.001). A positive correlation was found between Zn, Se, total antioxidant, and bone mineral density of femur (BMD.F) with activities of daily living (ADL) score (p < 0.01); meanwhile, a negative correlation between CZr and total oxidant with ADL score was observed (p < 0.01). Serum total oxidant level and CZr index had the highest area under the curve in receiver operating characteristic (ROC) analysis among the included parameters for discrimination of physically disabled patients than the normal ones. Decrease in serum Zn and Se levels, low BMD, and increase in CZr and oxidative stress were observed in physically disabled patients. It seems that CZr is more reliable parameter than the others to discriminate the physically disabled patients than the healthy persons.

Spectrophotometric assays for total antioxidant capacity (TAC) in dog serum: an update

“…There was no difference in serum concentrations of FRAP in patients with oral carcinoma before and after the treatment [ 55 ]. Hyperglycemia leads to lower FRAP values when compared to healthy subjects [ 56 ] and elderly physically disabled patients had lower FRAP values when compared to healthy ones [ 57 ].…”

Copper toxicology, oxidative stress and inflammation using zebrafish as experimental model

“…Cp can also promote inflammatory responses through elevated nitric oxide (NO) release and induction of pro‐inflammatory programs mediated by TNF, IL‐1β, cyclooxygenase‐2 (COX‐2), NADPH oxidase, iNOS (inducible nitric oxide synthase) and prostaglandin E 2 (PGE 2 ) (Choo et al , ). The copper plasma concentration is also elevated in patients with diabetes (Khan et al ., ) and physical disability (Younesi et al , ), as well as during aging. Interestingly, a low‐grade inflammatory status, or inflammaging , is an important component of aging‐related diseases (Malavolta et al , ) and systemic inflammation can cause redistribution of micronutrients that includes copper (Han et al , ; Malavolta et al , ).…”

Increased oxidative stress in patients with severe disability: Association with nutrition

“…In addition, supplementation of vitamin C and E was found to increase antioxidant enzymes such as superoxide dismutase and glutathione peroxidase . As for metal ions, serum Zn or Se were positively associated with total antioxidant ability in elderly patients with disability . In children with severe cerebral palsy, Schoendorfer et al .…”

“…24 As for metal ions, serum Zn or Se were positively associated with total antioxidant ability in elderly patients with disability. 25 In children with severe cerebral palsy, Schoendorfer et al found that serum Zn was well correlated with glutathione reductase or superoxide dismutase activity, particularly in orally fed patients. 26 Although we did not find any significant difference in oxidative stress between food and formula, physicians should pay attention to the fact that most semi-digestive nutritious liquids lack Se.…”