Dyslipidaemia & oxidative stress in patients of psoriasis

Abstract

Background & objectives:Psoriasis is a recurrent hyper-proliferative skin disease which is often associated with free radical generation, abnormal lipid metabolism and increased inflammatory secretion that induce cardiovascular risk in these patients. The present study was intended to evaluate serum lipids, lipoprotein and oxidants-antioxidants status and to establish their relationship with atherogenic risk markers [oxidized low-density lipoprotein (oxLDL) and high-sensitivity C-reactive protein (hsCRP)] in patients with psoriasis.Methods:The study was conducted on 150 psoriasis patients and 150 age- and sex-matched healthy controls. Overnight fasting blood samples were obtained for lipids, lipoproteins, lipid oxidation and peroxidation products [oxLDL, malondialdehyde (MDA)], antioxidant enzymes [reduced glutathione (GSH) and total antioxidant status] levels and hsCRP estimations.Results:The mean levels of atherogenic lipids [total cholesterol (P<0.001), triacylglycerol (P<0.01)], lipid peroxidation products (P<0.001) and oxLDL and hsCRP (P<0.001) levels in patients with psoriasis were found to be significantly higher than those of healthy controls. On the other hand, ferric-reducing ability of plasma (FRAP, P<0.001) and antioxidant enzyme activities (reduced GSH, P<0.01) were significantly lower when compared to healthy controls. The plasma oxLDL was positively correlated to LDL cholesterol (P<0.001) and MDA (P<0.001) and negatively associated with antioxidant status in these patients. Serum MDA, FRAP and oxLDL were correlated with risk of atherosclerosis in the patients with psoriasis; however, no significant association was found between reduced GSH and hsCRP.Interpretation & conclusions:The study results suggest that LDL oxidation and reactive oxygen species in addition to inflammatory markers may play a pivotal role in inducing atherosclerosis in patients of psoriasis.

Psoriasis and Cardiovascular Risk: A Comprehensive Review

“…Psoriasis is associated with an atherogenic lipid profile and significant lipid abnormalities have been noted even during 5 years preceding onset of psoriasis [35]. Similarly, another study reported that the mean oxLDL levels in patients with psoriasis were significantly higher than those of healthy controls [36].…”

Platelet Dysfunction and Its Role in the Pathogenesis of Psoriasis

“…More ROS produced owing to the inflammatory process may lead to the formation of lipid oxidation products such as malondialdehyde. Increased serum malondialdehyde was correlated with disease severity [85], and ROS also elevated the levels of protein oxidation products such as pyrrolized protein, protein carbonyl compounds, and advanced oxidation protein products [86].…”

Astilbin reduces ROS accumulation and VEGF expression through Nrf2 in psoriasis-like skin disease

“…Psoriasis is a chronic skin disease characterized by scaling, thickening and erythema of the skin, which is probably the most prevalent immune-mediated skin disease in adults [25]. Recent studies show that some mutations may lead to an abnormally increased activity of the immune system and, consequently, to increased inflammation and accompanying oxidative stress [26].…”