Dyslipidemia and associated factors among diabetic patients attending Durame General Hospital in Southern Nations, Nationalities, and People’s Region

Abstract

BackgroundDiabetes mellitus is a group of metabolic disorders that are caused by deficiency in insulin secretion or the decreased ability of insulin to act effectively on target tissues, particularly muscle, liver, and fat. As a result of insulin resistance in the target tissues, particularly in the adipocytes, free fatty acid flux is increased, leading to increased lipid synthesis in hepatocytes, which is responsible for diabetic dyslipidemia.ObjectiveThe objective of this study was to determine the prevalence and associated factors of dyslipidemia among diabetic patients in Durame General Hospital in Kembata Tembaro zone.MethodsA cross-sectional study was conducted from September 2015 to April 2016. In total, 224 subjects were involved in the study by using convenient sampling techniques. Face-to-face interview–administered questionnaire was used to collect sociodemographic data and other possible clinical data associated with the prevalence of dyslipidemia. Fasting venous blood specimens were collected to assess serum lipid profiles. Blood pressure (BP), weight, height, and waist circumference were measured.ResultsThe prevalence of dyslipidemia was 65.6%. Individual lipid abnormality of elevated LDL-C, TC, TG, and reduced HDL-C were identified in 43.8%, 23.7%, 40.6%, and 41.9% of study subjects, respectively. The prevalence of dyslipidemia was significantly associated with high BP, high body mass index, aging, and longer duration of diabetes mellitus.ConclusionHigh prevalence of dyslipidemia was found among diabetic patients in the study area. Therefore, a compressive mechanism is required to screen, treat, and prevent dyslipidemia.

Prevalence of dyslipidemia and its correlation with anthropometric and blood pressure variables among type-2 diabetic patients

“…The finding was comparable with the prevalence reported by Abdel-Aal et al (2008), which was 90%. However, the rate is much higher when compared with the study conducted in other part of Ethiopia (Bekele et al, 2017) where the prevalence of dyslipidemia was 65.6%. We found that the prevalence of abnormal lipid profiles of low HDL-c, high LDL-c, TG and TC were 60.8, 14.3, 70.4 and 32.8%, respectively.…”

“…The rate of low HDL-c, raised LDL-c, hypertriglyceridemia and hypercholesterolemia was lower than the finding reported from Jordan (Abdel-Aal et al, 2008) where 83.9, 91.5, 77.2, and 83.1% were the prevalence of low HDL-c, raised LDL-c, TC and TG, respectively. Conversely, lower rate of abnormal lipid profiles was reported from other similar region of South Ethiopia except LDL-c (Bekele et al, 2017). The variability may be attributed to the variations in individual's life style, geographical location, the rate of physical exercise performance.…”

“…Sample size was calculated based on single population proportion formula with 65.6% prevalence of dyslipidemia among DM patients (Bekele et al, 2017). Using the formula, the final sample size was calculated to be 346.…”

“…Mulugeta et al (2012) reported a significant correlation between glycemic control and dyslipidemia, particularly with serum TG and TC. Moreover, high BP, high BMI, aging, and experiences of prolonged duration with DM were significantly associated with the prevalence of dyslipidemia in DM patients (Bekele et al, 2017).…”

Metabolic-related markers and inflammatory factors as predictors of dyslipidemia among urban Han Chinese adults

“…In regard to obesity condition factor measured by BMI, the current study demonstrated a risk effect on dyslipidemia, similar to the findings from previous studies [7, 28]. Accumulating evidence indicate that a state of chronic inflammation play a crucial role in the pathogenesis of obesity-related metabolic dysfunction [29–31].…”