Dyslipidemia in dermatological disorders

Shenoy, Chetana; Shenoy, Manjunath Mala; Rao, Gururaja K

doi:10.4103/1947-2714.168657

Cited by 38 publications

(28 citation statements)

References 42 publications

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“…In the present study, atherogenic dyslipidemia associated with high CRF and AI values in infested animals is an indicator of their susceptibility towards cardiovascular diseases. Imbalance in lipid metabolism is associated with many dermatological disorders especially chronic inflammatory skin diseases such as psoriasis, litchen planus, granuloma annulare, and histiocytosis [76]. Chronic inflammation in animals with crusted scabies may explain the abnormal lipid profiles.…”

Section: Discussionmentioning

confidence: 99%

Host-Parasite Interaction in Sarcoptes scabiei Infestation in Porcine Model with a Preliminary Note on Its Genetic Lineage from India

Sawhney

Mondal

et al. 2020

Animals

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The burrowing mite Sarcoptes scabiei causes scabies in humans or mange in animals. It infests a wide range of mammalian species including livestock, companion animals, wild animals, and humans. Differential diagnosis of Sarcoptes varieties is key for epidemiological studies and for formulation of an eradication program. Host-parasite interaction at the systemic level is very important to understand the pathogenicity of the mite. This communication deals with the preliminary report on the genetic characterization of S. scabiei from India. Moreover, the effect of S. scabiei infestation on host physiology with special emphasis on serum biochemical parameters, lipid profile, oxidant/antioxidant balance, stress parameters, and immune responses were evaluated in a porcine model. Cytochrome C oxidase 1 and voltage-sensitive sodium channel based phylogenetic study could distinguish human and animals isolates but could not distinguish host or geographical specific isolates belonging to animal origin. An absence of host-specific cluster among animal isolates argues against the hypothesis of delineating S. scabiei as per host origin. Elevated levels of markers of liver function such as albumin, AST, ALT, ALP, and LDH in infested animals indicated impaired liver function in infested animals. S. scabiei infestation induced atherogenic dyslipidemia indicated by elevated levels of total cholesterol, low-density lipoprotein cholesterol and triglycerides, and a decreased level of high-density lipoprotein cholesterol. Oxidative stress in infested animals was indicated by a high level of nitric oxide and serum MDA as oxidative stress markers and low antioxidant capacity. S. scabiei triggered stress response and elevated levels of serum cortisol and heat shock proteins were recorded in infested animals. S. scabiei infestation increased the serum concentration of immunoglobulins and was associated with up-regulation of IL-2, IFN-γ, IL-1β, and IL-4 indicating both Th1 and Th2 response. The results of the study will be helpful for a better understanding of host-parasite interaction at the systemic level in crusted scabies in pigs.

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Section: Discussionmentioning

confidence: 99%

Host-Parasite Interaction in Sarcoptes scabiei Infestation in Porcine Model with a Preliminary Note on Its Genetic Lineage from India

Sawhney

Mondal

et al. 2020

Animals

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“…There are two peaks of incidence in psoriasis: 20–30 years of age and 50–60 years of age. Miller et al [ 4 ] confirm, based on a broad meta-analysis, that psoriasis is associated with cardiovascular diseases – ischemic heart disease, peripheral vessels disease and atherosclerosis, diabetes, arterial hypertension, dyslipidemia, and obesity [ 4 – 13 ]. Psoriatic patients show a higher risk of metabolic syndrome development, increasing with the disease severity [ 14 – 16 ].…”

Section: Introductionmentioning

confidence: 99%

Variances in the mRNA expression profile of TGF-β1–3 isoforms and its TGF-βRI–III receptors during cyclosporin a treatment of psoriatic patients

Michalska-Bańkowska

Wcisło‐Dziadecka

Grabarek

et al. 2018

pdia

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IntroductionPsoriasis is a chronic, immunologic, multi-factor inflammatory skin disease, strongly associated with a higher level of a number of cytokines, such as isoforms of transforming growth factor β (TGF-β1–3) and its receptors (TGF-βRI–III). One of the most popular and important drugs used to treat this disease is cyclosporin A (CsA).AimThe aim of this study was to investigate the expression of genes encoding the transforming growth factor (TGF)-β isoforms and receptors of the cytokine TGF-βRs in psoriatic patients during an 84-day long observation of the effects of cyclosporin A therapy. It made an attempt to determine the usefulness of testing mRNA expression of TGF-β1–3 and its receptors TGF-βRI–III as the supplementary molecular markers of lost sensitivity to the medicine.Material and methodsThe study group consisted of 32 patients with psoriasis (20 men and 12 women) treated with cyclosporin A. The changes in expression patterns of TGF-β1-3 and TGF-βRI-III were performed by real-time quantitative reverse transcription PCR (RTqPCR).ResultsThe expression of TGF-β1-3 and TGF-βRI-III were detected in the whole period of therapy with CsA. Changes in transcriptional activities of TGF-β1–3 and TGF-βRI–III during pharmacotherapy were observed. Differences in the expression of these genes were found before and after 42 and 84 days of using CsA.ConclusionsThe changes in expression profiles of TGF-β1-3 and TGF-βRI-III during CsA therapy can be a useful molecular marker of lost sensitivity to the medicine.

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“…CA has been associated with hypertension and varicosity in old ages [ 3 ] and hypertension by itself has been considered as a feature of metabolic syndrome [ 24 ] but we had to exclude hypertensive patients in our research because antihypertensive agents could be able to change lipid profile so it should be considered as a confounding factor. Also inflammatory factors decrease lipoprotein lipase activity in autoimmune skin diseases such as lichen planus, psoriasis, or pemphigus vulgaris which may result in dyslipidemia so we excluded these patients from this research [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Lipid Profile in Patients with Cherry Angioma: A Case-Control Study in Guilan, Iran

Darjani

Rafiei

Shafaei

et al. 2018

Dermatology Research and Practice

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Background Cherry angioma is the most common type of acquired cutaneous vascular proliferation which would increase with aging due to some angiogenic factors but the exact pathogenesis is unknown. Usually angiogenic factors are synthesized in human body to compensate occlusive effects of atherogenic agents such as serum lipids. Our hypothesis was that increased levels of these angiogenic factors could be a trigger for development of cherry angioma. This study has been designed to compare frequency of dyslipidemia in subjects with and without cutaneous cherry angioma. Methods In this case-control study, 122 cases with cherry angioma and 122 control subjects without cherry angioma were enrolled. Demographic characteristics, number of the cherry angioma lesions, and serum lipid profile were collected for all subjects. The data was analyzed using SPSS 18 software. Results Mean levels of the total cholesterol, triglyceride, low-density lipoprotein, and high-density lipoprotein were higher in patients with cherry angioma compared to control subjects in which differences were significant for total cholesterol, low-density lipoprotein, and triglyceride (P < 0.05) but not for high-density lipoprotein level. Conclusion Serum lipids may have a role in producing angiogenic factors and development of cherry angioma and it seems logical to evaluate lipid profile in these cases.

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Dyslipidemia in dermatological disorders

Cited by 38 publications

References 42 publications

Host-Parasite Interaction in Sarcoptes scabiei Infestation in Porcine Model with a Preliminary Note on Its Genetic Lineage from India

Host-Parasite Interaction in Sarcoptes scabiei Infestation in Porcine Model with a Preliminary Note on Its Genetic Lineage from India

Variances in the mRNA expression profile of TGF-β1–3 isoforms and its TGF-βRI–III receptors during cyclosporin a treatment of psoriatic patients

Evaluation of Lipid Profile in Patients with Cherry Angioma: A Case-Control Study in Guilan, Iran

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