Dyslipidemia in Insulin Resistance: Cause or Effect

Al-Mahmood, AK; Afrin, SF; Hoque, Nazmul

doi:10.3329/bjmb.v7i1.18576

Cited by 16 publications

(15 citation statements)

References 18 publications

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“…Again, angiotensin II acts directly on kidney and increases water and salt retention by the kidney and increases blood volume, cardiac output and blood pressure. [19][20] . In addition, hyperinsulinemia directly increases renal tubular reabsorption of sodium and also stimulates the synthesis of sodium retaining hormone aldosterone and ultimately hypertension develops.…”

Section: Discussionmentioning

confidence: 99%

Association of Serum Triglycerides and Total Cholesterol levels with Hypertension in Adult Female

Yeasmin

Akhter

Mahmuda

et al. 2019

Bangladesh Crit Care J

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Hyperlipidemia is one of the most widespread medical disorder in female and its complications are increasing all over the world, leading to life threatening medical problems like cardiovascular diseases, stroke and peripheral vascular diseases. An association between hyperlipidemia and hypertension has been identified. The study was carried out to observe the association of serum triglycerides and total cholesterol level with hypertension in adult female subjects. This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka, during the period of January 2011 to December 2011. A total number of sixty female subjects were selected with age ranging from 30 to 50 years. Among them 30 female subjects with hypertension were included from the out-patient department of Medicine, Dhaka Medical College Hospital, Dhaka as study group (B) and 30 apparently healthy females were taken as control group (A) for comparison. Estimation of fasting serum triglycerides (TG) and total cholesterol (TC) levels were done by enzymatic method in the Department of Physiology, Dhaka Medical College Dhaka in both groups. Systolic blood pressure and diastolic blood pressure of all participants were recorded by standard method. Data were analyzed by Unpaired Student’s- test and Pearson's correlation co-efficient (r) test as applicable. The values of fasting serum TG level were significantly higher in subjects with hypertension than those of control. Fasting serum TC level was significantly higher in subjects with hypertension in comparison to controls also. In subjects with hypertension fasting serum TG and fasting serum TC levels were higher and showed positive correlation with systolic and diastolic blood pressure. Present study revealed that systolic and diastolic blood pressure has positive relationship with fasting serum triglyceride (TG) and fasting serum cholesterol (TC) levels. Bangladesh Crit Care J March 2019; 7(1): 35-39

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Section: Discussionmentioning

confidence: 99%

Association of Serum Triglycerides and Total Cholesterol levels with Hypertension in Adult Female

Yeasmin

Akhter

Mahmuda

et al. 2019

Bangladesh Crit Care J

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“…Although the strong association between these pathogenetic factors has long been recognized [1–3], it is largely unknown which factor is the precursor, or whether the temporal relationship between them is bidirectional [4, 5]. Therefore, it is necessary to clarify the temporal relationship between these factors in order to provide an early and effective target for preventing type 2 diabetes (T2D) and cardiovascular disease (CVD).…”

Section: Introductionmentioning

confidence: 99%

Changes in triglycerides and high-density lipoprotein cholesterol may precede peripheral insulin resistance, with 2-h insulin partially mediating this unidirectional relationship: a prospective cohort study

Han

Chen

Tian

et al. 2016

Cardiovasc Diabetol

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BackgroundResults of longitudinal researches regarding the temporal relationship between dyslipidemia and insulin resistance (IR) are inconsistent. This study assessed temporal relationships of blood lipids with IR and determined whether there are any mediating effects existed in these temporal relationships.MethodsThis study examined a longitudinal cohort of 3325 subjects aged 20–74 years from China with an average of 4.2 years follow-up. Measurements of fasting blood lipids, as well as fasting and 2-h serum glucose and insulin, were obtained at two time points. The Gutt index and HOMA-IR were calculated as indicators of peripheral IR and hepatic IR. A cross-lagged path analysis was performed to examine the temporal relationships between blood lipids and IR. A mediation analysis was used to examine mediating effect.ResultsAfter adjusting for covariates, the cross-lagged path coefficients from baseline TG and HDL-C to follow-up Gutt index were significantly greater than those from baseline Gutt index to follow-up TG and HDL-C (β1 = −0.131 vs β2 = −0.047, P < 0.001 for TG; β1 = 0.134 vs β2 = 0.023, P < 0.001 for HDL-C). The path coefficients from baseline TG and HDL-C to follow-up 2-h insulin were significantly greater than those from baseline 2-h insulin to follow-up TG and HDL-C (β1 = 0.125 vs β2 = 0.040, P < 0.001 for TG; β1 = −0.112 vs β2 = −0.026, P < 0.001 for HDL-C). 2-h insulin partially mediated the effect of TG/HDL-C on Gutt index with a 59.3% mediating effect for TG and 61.0% for HDL-C.ConclusionsThese findings provide strong evidence that dyslipidemia probably precede peripheral IR and that 2-h insulin partially mediates this unidirectional temporal relationship.Electronic supplementary materialThe online version of this article (doi:10.1186/s12933-016-0469-3) contains supplementary material, which is available to authorized users.

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“…Again, angiotensin II acts directly on kidney and increase water, salt retention by the kidney and increase blood volume, cardiac output and blood pressure 25 . In addition, hyperinsulinemia directly increase renal tubular reabsorption of sodium and also stimulates the synthesis of sodium retaining hormone, aldosterone and ultimately hypertension develops 26,27 . Similarly, hyperinsulinemia with insulin resistance increase intracellular Ca++ accumulation, increases secretion of growth factors and vascular smooth muscle cell proliferation, as a result narrowing of blood vessels and hypertension develops 28,29 .…”

Section: Discussionmentioning

confidence: 99%

Association of Serum Low Density Lipoprotein Cholesterol and High Density Lipoprotein Cholesterol with Hypertension in Adult Female

Mahmuda¹,

Yeasmin²,

Abira³

et al. 2018

Bangladesh Crit Care J

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Background: Hypertension is a chronic and debilitating disease. Its complications are increasing all over the world, leading to life threatening medical problems like cardiovascular diseases, stroke and end stage renal diseases. An association between hyperlipidemia and hypertension has been identified.Objectives: The study was carried out to observe the association of serum low density lipoprotein cholesterol and high density lipoprotein cholesterol level with hypertension in adult female subjects.Method: This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka, during the period of January 2011 to December 2011. A total number of sixty female subjects were selected with age ranging from30 to50 years. Among them 30 female subjects with hypertension were included from out-patient department of Medicine, Dhaka Medical College Hospital, Dhaka as study group(B) and 30 apparently healthy females were taken as control group(A) for comparison. Estimation of serum fasting serum low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) levels were done by enzymatic method in the Department of Physiology, Dhaka Medical College Dhaka in both groups. Systolic blood pressure and diastolic blood pressure of all participants were recorded by standard method. Data were analyzed by Unpaired Student’s- test and Pearson's correlation co-efficient (r) test as applicable.Result: The value of fasting serum LDL level was significantly higher in subjects with hypertension than those of control. Fasting serum HDL level was significantly lower in subjects with hypertension in comparison to control. In subjects with hypertension fasting serum LDL-C showed positive correlation with systolic and diastolic blood pressure and serum HDL-C showed negative correlation with systolic and diastolic blood pressure.Conclusion: Present study revealed that systolic and diastolic blood pressure has positive relationship with low density lipoprotein cholesterol (LDL-C) and negative relationship with high density lipoprotein cholesterol (HDL-C) levels.Bangladesh Crit Care J September 2018; 6(2): 74-79

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Dyslipidemia in Insulin Resistance: Cause or Effect

Cited by 16 publications

References 18 publications

Association of Serum Triglycerides and Total Cholesterol levels with Hypertension in Adult Female

Association of Serum Triglycerides and Total Cholesterol levels with Hypertension in Adult Female

Changes in triglycerides and high-density lipoprotein cholesterol may precede peripheral insulin resistance, with 2-h insulin partially mediating this unidirectional relationship: a prospective cohort study

Association of Serum Low Density Lipoprotein Cholesterol and High Density Lipoprotein Cholesterol with Hypertension in Adult Female

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