Dyslipidemia in Pediatric Type 2 Diabetes Mellitus

Sunil, Bhuvana; Ashraf, Ambika P.

doi:10.1007/s11892-020-01336-6

Cited by 41 publications

(32 citation statements)

References 95 publications

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“…This typically occurs as a component of metabolic syndrome. 32,33 Patients with T2DM usually have low high density lipoprotein cholesterol (HDL-C) and elevated levels of triglycerides, non-HDL cholesterol and low-density lipoprotein cholesterol (LDL-C) concentrations. Hypertension is also noted frequently in children and adolescents with T2DM.…”

Section: Health Consequences Of T2dm In Adolescents Cardiovascular Riskmentioning

confidence: 99%

Adolescents with Type 2 Diabetes: Overcoming Barriers to Effective Weight Management

Biggs¹,

Creo²,

Prissel³

et al. 2023

DMSO

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The prevalence of type 2 diabetes (T2DM) among children and adolescents has remarkably increased in the last two decades, particularly among ethnic minorities. Management of T2DM is challenging in the adolescent population due to a constellation of factors, including biological, socioeconomic, cultural, and psychological barriers. Weight reduction is an essential component in management of T2DM as weight loss is associated with improvement in insulin sensitivity and glycemic status. A family centered and culturally appropriate approach offered by a multidisciplinary team is crucial to address the biological, psychosocial, cultural, and financial barriers to weight management in youth with T2DM. Lifestyle interventions and pharmacotherapy have shown modest efficacy in achieving weight reduction in adolescents with T2DM. Bariatric surgery is associated with excellent weight reduction and remission of T2DM in youth. Emerging therapies for weight reduction in youth include digital technologies, newer GLP-1 agonists and endoscopic procedures.

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Section: Health Consequences Of T2dm In Adolescents Cardiovascular Riskmentioning

confidence: 99%

Adolescents with Type 2 Diabetes: Overcoming Barriers to Effective Weight Management

Biggs¹,

Creo²,

Prissel³

et al. 2023

DMSO

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“…To determine whether the degree of the vasodilation correlates with the levels of plasma LDL, we separated the subjects into a low-LDL group (plasma LDL <100 mg/dL, 11 subjects) and a high-LDL group (>100 mg/ dL, 9 subjects), the target range for LDL cholesterol according to recent American Heart Association guidelines. [21][22][23] The 2 groups differed significantly in the levels of total and LDL cholesterol, LDL/HDL (high-density lipoprotein) ratios, and triglycerides but not in the level of HDL, glucose, insulin, or BMI (Table ). A significant reduction in the FIV in the high-LDL group was observed at Δ60 cmH 2 O and Δ100 cmH 2 O pressure gradients (Figure 3A).…”

Section: Decrease In Fiv In Human Resistance Arteries As a Function O...mentioning

confidence: 99%

Cholesterol-Induced Suppression of Endothelial Kir Channels Is a Driver of Impairment of Arteriolar Flow-Induced Vasodilation in Humans

et al. 2022

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Dyslipidemia-induced endothelial dysfunction is an important factor in the progression of cardiovascular disease; however, the underlying mechanisms are unclear. Our recent studies demonstrated that flow-induced vasodilation (FIV) is regulated by inwardly rectifying K + channels (Kir2.1) in resistance arteries. Furthermore, we showed that hypercholesterolemia inhibits Kir2.1-dependent vasodilation. In this study, we introduced 2 new mouse models: (1) endothelial-specific deletion of Kir2.1 to demonstrate the role of endothelial Kir2.1 in FIV and (2) cholesterol-insensitive Kir2.1 mutant to determine the Kir2.1 regulation in FIV under hypercholesterolemia. FIV was significantly reduced in endothelial-specific Kir2.1 knock-out mouse mesenteric arteries compared with control groups. In cholesterol-insensitive Kir2.1 mutant mice, Kir2.1 currents were not affected by cyclodextrin and FIV was restored in cells and arteries, respectively, with a hypercholesterolemic background. To extend our observations to humans, 16 healthy subjects were recruited with LDL (low-density lipoprotein)-cholesterol ranging from 51 to 153 mg/dL and FIV was assessed in resistance arteries isolated from gluteal adipose. Resistance arteries from participants with >100 mg/dL LDL (high-LDL) exhibited reduced FIV as compared with those participants with <100 mg/dL LDL (low-LDL). A significant negative correlation was observed between LDL cholesterol and FIV in high-LDL. Expressing dominant-negative Kir2.1 in endothelium blunted FIV in arteries from low-LDL but had no further effect on FIV in arteries from high-LDL. The Kir2.1-dependent vasodilation more negatively correlated to LDL cholesterol in high-LDL. Overexpressing wild-type Kir2.1 in endothelium fully recovered FIV in arteries from participants with high-LDL. Our data suggest that cholesterol-induced suppression of Kir2.1 is a major mechanism underlying endothelial dysfunction in hypercholesterolemia.

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“…Glycosylated haemoglobin (A1c) is a standard test for the monitoring of blood sugar status [21]. The higher the blood lipid level, the higher the blood glucose level; in addition, dyslipidaemia can increase the risk of diabetes [22]. Observations confirmed the putative utility of dyslipidaemia in CVD risk prediction in individuals with diabetes [23].…”

Section: Introductionmentioning

confidence: 99%

Combined Effects of Obesity and Dyslipidaemia on the Prevalence of Diabetes Amongst Adults Aged ≥45 Years: Evidence from a Nationally Representative Cross-Sectional Study

Zhang

Sun

Xia

et al. 2022

IJERPH

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Objectives: This study aimed toexplore the combined effects of different types of obesity and dyslipidaemia on the prevalence of diabetes in middle-aged and elderly residents. Methods: Data were obtained from the 2015 China Health and Retirement Longitudinal Studydatabase, and 5023 valid participants were included after excluding those with missing data. A Chi-square test was used to test the difference in the prevalence of diabetes between the groups. Binary logistic regression was used to analyse the relationship between different types of obesity combined with dyslipidaemia and the prevalence of diabetes. Results: Multivariate logistic regression analysis showed that, compared with those with a body mass index <24/ortholiposis, the subgroup with systemic obesity/dyslipidaemia had 4.37 times the risk of diabetes (OR = 4.37, 95% CI = 2.36–8.10, p < 0.001). In addition, compared with those with a normal waist circumference (WC)/ortholiposis, the subgroup with abdominal obesity/dyslipidaemia had 3.58 times the risk of diabetes (OR = 3.58, 95% CI = 2.49–5.13, p < 0.001). Conclusions: The coexistence of obesity and dyslipidaemia can significantly increase the risk of diabetes, suggesting that the strict control of weight, WC and lipid level is beneficial to the prevention of diabetes.

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Dyslipidemia in Pediatric Type 2 Diabetes Mellitus

Cited by 41 publications

References 95 publications

Adolescents with Type 2 Diabetes: Overcoming Barriers to Effective Weight Management

Adolescents with Type 2 Diabetes: Overcoming Barriers to Effective Weight Management

Cholesterol-Induced Suppression of Endothelial Kir Channels Is a Driver of Impairment of Arteriolar Flow-Induced Vasodilation in Humans

Combined Effects of Obesity and Dyslipidaemia on the Prevalence of Diabetes Amongst Adults Aged ≥45 Years: Evidence from a Nationally Representative Cross-Sectional Study

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