Dyslipidemia in subclinical hypothyroidism in an Indian population

Marwaha, Raman K.; Tandon, Nikhil; Garg, MK; Kanwar, Ratnesh; Sastry, A. V. R.; Narang, Amit; Arora, Saurav; Bhadra, Kuntal

doi:10.1016/j.clinbiochem.2011.07.003

Cited by 51 publications

(43 citation statements)

References 34 publications

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“…Our results did not reveal any significant differences of LDL levels in patients in comparison to control group. Several studies revealed contemporary elevation of TC and LDL [36][37][38], although many studies could not detect any alterations of lipid profile in sHT patients in comparison to control group [39][40][41], exactly similar to our investtigation that we could not demonstrate any differences in lipid profile of sHT and control group. In spite of all that, our study detected significant differences in serum TG levels between before and after treatment groups so that TG levels decreased meaningfully after treatment.…”

Section: Discussionsupporting

confidence: 78%

Serum levels of nitrite/nitrate, lipid profile, and Fasting Plasma Glucose and their associations in subclinical hypothyroid women before and after a two month treatment by levothyroxine

Hashemi

Kosari

Mansourian

et al. 2017

Romanian Journal of Internal Medicine

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Background. Subclinical hypothyroidism (sHT) is a condition defined by elevated TSH values with normal levels of free thyroid hormones. Altered metabolic status is one of the consequences of sHT which can affect serum levels of FPG, lipid profile, and nitric oxide which propounds cardiovascular consequences per se. The aim of this study was to determine the possible effects of sHT on nitrite/nitrate levels, as a marker of endothelial performance.Materials and Methods. 50 females were enrolled in this study, 25 women as control group and 25 women as case group (evaluated two times: before and after levothyroxine therapy). Blood samples were collected and levels of FPG, lipid profile components, and nitric oxide were measured spectrophotometrically. The data were analyzed using SPSS version 18 software.Results. The levels of lipid profile (except for TG between before and after group, p < 0.05) and nitric oxide did not differ in groups while FPG was significantly higher in case groups in comparison to control group (p < 0.001). Nitric oxide had no correlations with any of variables except for LDL in after treatment group (p < 0.05 and r = 0.397).Conclusion. Nitric oxide does not have correlation with components of lipid profile (except for LDL) or FPG and has no differences in subclinical hypothyroid patients and control group. Levothyroxine therapy during 2 months cannot alter the levels of nitric oxide in subclinical hypothyroid patients.

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Section: Discussionsupporting

confidence: 78%

Serum levels of nitrite/nitrate, lipid profile, and Fasting Plasma Glucose and their associations in subclinical hypothyroid women before and after a two month treatment by levothyroxine

Hashemi

Kosari

Mansourian

et al. 2017

Romanian Journal of Internal Medicine

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“…Further, high levels of triglycerides often alter the correlation between apolipoprotein B level and LDL-C in patients with metabolic syndrome (25) . The lipid alterations are also observed in systemic autoimmune diseases as reported by Marwaha et al (26) . The present study therefore demonstrates the significance of altered lipid levels in subjects diagnosed with SCH.…”

Section: Resultssupporting

confidence: 58%

A Case Control Study of Serum Lipid Level Alterations in Subclinical Hypothyroid Patients

Angadi¹

2017

jmscr

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“…10 A study based on an Indian population (n = 5343) included both adults and children/adolescents. 12 The prevalence of SCH was 13.5%. When SCH subjects were divided into 2 groups using a TSH cut-off point of 10 mU/l, those with a TSH level below this value showed no lipid abnormalities.…”

Section: Sch and Dyslipidemiamentioning

confidence: 99%

Subclinical hypothyroidism and vascular risk: Αn update

Lioudaki¹,

Mavroeidi²,

Mikhailidis³

et al. 2013

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subclinical hypothyroidism (scH), defined as elevated serum thyroid-stimulating hormone (tsH) in the presence of normal circulating free thyroxine (Ft4) and triiodothyronine (t3), is a relatively common condition. replacement treatment with levothyroxine is justified only for individuals with tsH levels >10 mIU/l. serum lipid levels are influenced by thyroid status and there is evidence pointing to a link between scH and an unfavorable lipid profile. Despite some conflicting data, most studies suggest that levothyroxine treatment may exert a beneficial effect on the lipid profile in scH regarding mainly total cholesterol and low-density lipoproteincholesterol. Moreover, it appears that treatment may also improve some other markers associated with cardiovascular (cV) disease such as carotid intima media thickness ( 17-03-201317-03- , Accepted 20-10-2013 Review (FT4) and triiodothyronine (T3) levels within the reference range.1 This is a relatively common condition with a prevalence ranging from 4 to 15% in the general population and up to 20% among females aged >60 years. [2][3][4][5]

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Dyslipidemia in subclinical hypothyroidism in an Indian population

Cited by 51 publications

References 34 publications

Serum levels of nitrite/nitrate, lipid profile, and Fasting Plasma Glucose and their associations in subclinical hypothyroid women before and after a two month treatment by levothyroxine

Serum levels of nitrite/nitrate, lipid profile, and Fasting Plasma Glucose and their associations in subclinical hypothyroid women before and after a two month treatment by levothyroxine

A Case Control Study of Serum Lipid Level Alterations in Subclinical Hypothyroid Patients

Subclinical hypothyroidism and vascular risk: Αn update

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