Dyslipidemia in Type 2 Diabetes Mellitus With Poor Glycemic Control: Prevalence, Associated Factors, and Relationship Between HbA1c and Lipid Profile.

Abstract

BackgroundCcompared with HbA1c<7% ,T2DM patients with HbA1c≥7% had significantly higher levels of lipid profile, however, it is unknown whether there was a linear and significant increase levels of lipid profile associated with HbA1c value of ≥7%. This study identified the lipid profile across a full range of poor glycemic control and the association between lipid profiles with different specific HbA1c cutoffs.MethodsA total of 1183 type 2 diabetes patients with poor glycemic control (HbA1c>7%) selected through convenience sampling in three hospitals of Jiangsu province were surveyed. Dyslipidemia was defined according to criteria of the Third Report of the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III). ResultsThe prevalence of dyslipidemia was 55.2 % overall. Of 1183 subjects, 13.0% had high TC, 33.1% had low HDL-C, 9.9% had high LDL-C, and 28.4% had high TG concentrations. There was an increase in frequency of dyslipidemia in patients with different cutoff values of HbA1c (P<0.05).The prevalence of high TC was closely related with different cutoff values of HbA1c (adjusted OR =1.77, 2.56 3.82, respectively). Patients with HbA1c values 9%≤HbA1c<11% and HbA1c≥13% had significantly higher prevalence of dyslipidemia compared with the patients who had 7≤HbA1c<9%.ConclusionDiabetic patients with 9%≤HbA1c<11% and HbA1c≥13% tend to have moderate and severe dyslipidemia respectively and suggest the importance of glycemic control in normalizing dyslipidemia.