Dyslipidemia in Type 2 Diabetes Mellitus Patients With Poor Glycemic Control: Relationship Between HbA1c and Lipid Profile.

Xu, Huiwen; Qiu, Shuang; Yuan, Xun; Zou, Yan; Takashi, En; Kitayama, Akio; Li, Lin

doi:10.21203/rs.3.rs-258114/v1

Cited by 1 publication

(1 citation statement)

References 23 publications

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“…This trend is consistent with cross-sectional studies carried out in Spain, China, the United Arab Emirates, Eritrea, and Kenya. 10 , 12 , 15 , 18 , 20 , 21 This correlation arises from the close relationship between blood glucose and lipid metabolism, both of which tend to rise with increasing body weight.…”

Section: Discussionmentioning

confidence: 99%

The Burden of Dyslipidemia and Determinant Factors Among Type 2 Diabetes Mellitus Patients at Hawassa University Comprehensive Specialized Hospital, Hawassa, Ethiopia

Kelemework,

Woubshet,

Tadesse

et al. 2024

DMSO

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Background Diabetes is a global health challenge with escalating prevalence rates. Cardiovascular complications represent the leading cause of mortality among individuals with diabetes. Notably, dyslipidemia stands as a prominent risk factor for cardiovascular disease in Type 2 diabetes mellitus (T2DM) patients. Timely detection and management of dyslipidemia in these patients hold the potential to deter its progression and substantially reduce the risk of cardiovascular-related morbidity and mortality. This study was aimed at assessing the burden of dyslipidemia and determinant factors among T2DM patients who were being followed at the Endocrinology clinic of Hawassa University Comprehensive Specialized Hospital (HUCSH). Methodology An Institutional- based retrospective cross-sectional study was conducted, and samples of 228 patients were selected using a systematic random sampling technique. Data were collected through structured face-to-face interviews using a questionnaire. Bivariate logistic analysis was utilized, and variables with a p-value < 0.25 in this analysis were considered candidates for multivariate logistic analysis. Multivariate logistic regression was employed to identify factors associated with the prevalence of dyslipidemia, with a significance threshold set at p < 0.05. Results The research revealed an overall prevalence of dyslipidemia among the study participants at 75.9%. The specific manifestations of dyslipidemia were observed as follows: hypertriglyceridemia in 43%, hypercholesterolemia in 25%, elevated low-density lipoprotein in 59.2%, and reduced high-density lipoprotein in 33.3% of the study participants. Factors significantly associated with dyslipidemia included longer diabetes duration, poor physical activity, elevated HbA1C, and obesity. Conclusion This study underscores a notably high prevalence of dyslipidemia among T2DM patients. The findings highlight the advocate for clinicians to prioritize routine screening, and effective treatment concerning dyslipidemia and its associated risk factors among individuals with T2DM. It is worth mentioning that this study was conducted in a specific hospital setting and limited time, and hence the findings, and generalizability to other healthcare facilities should be taken cautiously.

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