Dyslipidemia therapy update: the importance of full lipid profile assessment

Abstract

Lipid guidelines typically focus on total cholesterol +/- low-density lipoprotein cholesterol levels with less emphasis on high-density lipoprotein cholesterol (HDL-C) or triglyceride assessment, thus potentially underestimating cardiovascular (CV) risk and the need for lifestyle or treatment optimization. In this article, we highlight how reliance on isolated total cholesterol assessment may miss prognostically relevant lipid abnormalities; we describe from the European Systematic COronary Risk Evaluation (SCORE) data set how incorporation of HDL-C may improve estimation of CV risk; and, finally, we critically evaluate the evidence base surrounding triglycerides and CV risk.

Can the Sasang Constitutional Type Trait Act as an Independent Risk Factor for Dyslipidemia?

“…The Also, TG and HDL-chol levels are taken into consideration when deciding on the LDL-chol goals, following the basic principles of 'risk-reduction' therapy that adjusts the intensity of lipid control strategy to a person's risk status 1,[23][24][25][26] . The heightened propensity of 'high TG' and 'low HDL-chol' found in the TE constitutional type compared to other types could add to the CHD risk, on par with the increased risk of arteriosclerotic sequelae in TE types reported in literature 27,28) .…”

Evidence that supports the prescription of low-carbohydrate high-fat diets: a narrative review

“…76 78 79 First, the LCHF-induced increase in HDL-C concentrations is considered protective against cardiovascular disease 80. In contrast, LFHC diets do not produce an equivalent HDL-C-raising effect and may in fact cause HDL-C concentrations to fall,72 a potentially detrimental effect.…”

Lipid Profile Changes During the First Year After Kidney Transplantation: Risk Factors and Influence of the Immunosuppressive Drug Regimen

“…Current prevention guidelines also support optimal high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) concentrations to further reduce the incidence of cardiovascular events. 6 Furthermore, reduction in the atherogenic non-non-HDL-C lipid fraction 7 may be superior to LDL-C to predict cardiovascular events. 8 There is no consensus regarding the utility of TC: HDL-C, LDL:HDL-C, or TG:HDL-C ratios to predict coronary heart disease risk.…”