Dyspepsia and gastroparesis in chronic renal failure: the role of Helicobacter pylori

Schoonjans, Renaat; Van, Vlem B; Vandamme, Wouter; Van, Heddeghem N; Verdievel, H.; Vanholder, Raymond; Lameire, Norbert; De, Vos M

doi:10.5414/cnp57201

Cited by 51 publications

(42 citation statements)

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“…Upper GI abnormalities are common among adult uremic patients even in the absence of symptoms [1][2][3]. Several factors, such as the cause of terminal uraemia, immunosuppressive medication and infections, can predispose kidney transplantation patients to the development of GI problems.…”

Section: Introductionmentioning

confidence: 99%

Gastrointestinal Evaluation in Chronic Kidney Diseases

Krishnan¹,

Venkataraman²

2011

J Nephrol Therapeutic

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Section: Introductionmentioning

confidence: 99%

Gastrointestinal Evaluation in Chronic Kidney Diseases

Krishnan¹,

Venkataraman²

2011

J Nephrol Therapeutic

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“…HP enfeksiyonu ve son dönem böbrek yetmezliği ile ilgili yapılan çalışmalarda bazı yazarlar asemptomatik vakalarda rutin serolojik taramanın gerekli olmadığını söylese de, erişkin hastalarda yapılan bazı çalışmalarda, bizim vakalarımızda olduğu gibi asemptomatik üremik hastalarda da gastrointestinal lezyonların sık görüldüğü bildirilmiştir (29)(30)(31)(32). Erişkin hemodiyaliz hastalarında yapılan bir çalışmada, dokuda HP pozitifliği %63 olarak bildirilirken, anormal endoskopi bulguları olan hastaların %85.7'sinde HP tespit edilmiştir (32).…”

Section: Discussionunclassified

Kronik Böbrek Yetmezliği Nedeni ile Diyaliz Yapılan Çocuklarda Helikobakter Pilori Enfeksiyonu

Genç¹,

Çaltepe²,

Özkaya³

et al. 2013

Haseki

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1 ÖzetAmaç: Bu çalışmada, kronik böbrek yetmezlikli çocuk hastalarda gastrointestinal semptomlar ile Helicobacter pilori (HP) enfeksiyonu sıklığınının araştırılması planlanmıştır. Yöntem: Çalışmaya kronik böbrek yetmezlikli 33 hasta ile yaş ve cinsiyeti aynı olan sağlıklı kontroller dahil edildi. Hastaların demografik, serolojik ve endoskopik bulguları incelendi ve gastrointestinal sistem semptomları sorgulandı. Çalışmaya dahil edilen tüm hasta ve kontrol grubundan serumda HP-IgG düzeyi çalışıldı. Bulgular: Yirmi yedi periton diyalizi, altı hemodiyaliz hastası çalışmaya dahil edildi. HP seropozitifliği hasta grubunda %51.5, kontrol grubunda %60.6 olarak tespit edildi (p=0.46). Yirmi hastaya özefagogastroduodenoskopi uygulandı ve hastaların %30'unda dokuda HP tespit edildi. Dispepsi tüm hastaların %42.2'sinde belirlendi. Dispeptik hastaların %57.1'inde HP seropozitifliği, %36.4'ünde dokuda HP tespit edildi. Pozitif serolojisi olan hastaların %60'ında dokuda HP gösterilirken, seronegatif olan sadece bir olguda dokuda HP tespit edildi. Sonuç: Toplumumuzda sık görülen ve kolonizasyonu çocukluk yaşlarında başlayan HP enfeksiyonu, çalışmamızda da serolojik olarak hem hasta hem de kontrol grubunda yüksek bulunmuştur. Her biri transplantasyon adayı olan bu hastalar için asemptomatik olsa bile enfeksiyonun saptanması ve tedavisi önem taşımaktadır. Abs tractAim: We aimed to investigate the frequency of gastrointestinal symptoms and Helicobacter pylori (HP) infection in children with chronic renal failure. Methods: The study involved 33 patients with end-stage renal disease and 33 age-and sex-matched healthy controls. Serological, endoscopic and demographic features of the patients were determined and gastrointestinal symptoms were questioned. HP IgG levels were evaluated in all patients and controls. Results: Twenty-seven peritoneal dialysis and 6 hemodialysis patients were included in the study. The HP seropositivity was 51.5% and 60.6% in uremic children and normal controls, respectively (p=0.46). Twenty patients underwent esophagogastroduodenoscopy and HP was detected in 30% of them. Dyspepsia was observed in 42.4% of all patients. In patients with dyspepsia, HP seropositivity rate was 57.1% and biopsy proven HP was 36.4%. Biopsy proven HP was determined in 60% of patients with positive serology and in one with negative serology. Conclusion: HP infection, which is common in our population and begins in early childhood, is found to be frequent in both patient and healthy groups. Even if asymptomatic, it is very important to determine and treat this infection, in these patients who are potential transplant candidates. (The Me di cal Bul le tin of Ha se ki 2013; 51: 1-4)

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“…Patients with chronic renal failure often have gastrointestinal symptoms caused by several factors, such as H. pylori infection, high urea levels, decline in gastrointestinal motility, amyloid protein deposition, and increased sensory disturbance [25,26] . Therefore, the quality of life in patients with CKD including HD patients is usually poor with a poor nutrition status, thus contributing to 231 the development of malnutrition, which is a potent predictor of morbidity and mortality [27] .…”

Section: Discussionmentioning

confidence: 99%

Severity of Gastric Mucosal Atrophy Is the Major Determinant of Plasma Ghrelin Level in Hemodialysis Patients

Sakao

Sugimoto²,

Ichikawa³

et al. 2016

Am J Nephrol

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Background: Ghrelin, an orexigenic hormone, has multiple favorable functions including protein anabolism enhancement, anti-inflammatory actions, and cardiovascular protection. A low plasma ghrelin level is associated with increased mortality in patients treated with hemodialysis (HD). However, it is unclear whether the plasma ghrelin level in HD patients correlates with the severity of gastric mucosal atrophy and Helicobacter pylori status. Methods: Seventy-eight maintenance HD patients and 51 non-dialysis patients with chronic kidney disease were evaluated for severity of gastric mucosal atrophy by gastroduodenoscopy and for H. pylori status using an anti-H. pylori-antibody and rapid urease test. Plasma acyl and des-acyl ghrelin levels were measured and their associations with relevant clinical parameters were investigated. Results: Des-acyl ghrelin level in HD patients was significantly higher than that in patients with kidney function preserved. Although acyl and des-acyl ghrelin levels were similar between current H. pylori positive and negative HD patients, both levels decreased significantly with the progress of endoscopic gastric mucosal atrophy in HD patients. Serum pepsinogen (PG) I level and PG I/II ratio decreased significantly according to the severity of atrophy in HD patients and positively significantly correlated with both ghrelin levels. Multiple regression analysis showed significant positive correlations between acyl ghrelin and PG I levels (β = 0.738, p < 0.001) and significant negative correlations between ghrelin and age, albumin, and creatinine levels. Conclusions: Gastric atrophy is the major determinant of ghrelin level in HD patients. Management practices, such as H. pylori eradication, before advanced atrophy may be required to prevent the decrease of ghrelin levels and improve the prognosis of HD patients.

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Dyspepsia and gastroparesis in chronic renal failure: the role of Helicobacter pylori

Cited by 51 publications

References 0 publications

Gastrointestinal Evaluation in Chronic Kidney Diseases

Gastrointestinal Evaluation in Chronic Kidney Diseases

Kronik Böbrek Yetmezliği Nedeni ile Diyaliz Yapılan Çocuklarda Helikobakter Pilori Enfeksiyonu

Severity of Gastric Mucosal Atrophy Is the Major Determinant of Plasma Ghrelin Level in Hemodialysis Patients

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