Dysplastic Nevus and BCC development after antihypertensive therapy with Valsartan and Hydrochlorothiazide!?

Malev, Valeri; Tchernev, Georgi

doi:10.15226/2378-1726/6/5/001105

Cited by 1 publication

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References 7 publications

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“…The simultaneous occurrence of basal cell carcinomas (BCC) and dysplastic nevi after taking sartans or sartans in combination with hydrochlorothiazide could be consideredas extremely important, eventually confirmatory, regarding the thesis that potential contamination with nitrosamines is able to generate multiple forms of cancer or skin cancer and/or its precursors 4,5 . Contamination with mutagenic nitrosamine remains the link between the intake of sartans and the development of skin cancer.…”

Section: Introductionmentioning

confidence: 99%

Giant BCC of the scalp after telmisartan/amlodipine: potential role of nitrosamine contamination as main cause for skin cancer development

Tchernev¹,

Kordeva²

2024

PJDV

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The problem of drug-induced cancers, and in particular skin cancers after intake of various antihypertensive drugs, is increasing, but at the same time is gaining some clarity. In addition to melanocytic cancers, development of keratinocytic cancers is increased after the administration of sartans. It is believed that the procarcinogenic potential of the medication could be due to contamination of tablets with nitrosamines, which are known as mutagens. Regardless of the presence of angiotensin receptors in the skin and tumor tissue, the pharmacologic influence of the sartan is considered to be secondary and insignificant in relation to the processes of carcinogenesis. In certain cases, this influence is even defined as an antitumorous effect. We present a female patient who had been taking telmisartan/amlodipine 80/5 mg daily for 9 years and, after 4-5 years, developed a scalp tumor, confirmed histopathologically as a basal cell carcinoma (BCC) and treated successfully by surgical excision. The discussion is mainly focused on the potential role of nitrosamines as a new key player in the pathogenesis of keratinocytic cancers and BCC in particular.

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Section: Introductionmentioning

confidence: 99%

Giant BCC of the scalp after telmisartan/amlodipine: potential role of nitrosamine contamination as main cause for skin cancer development

Tchernev¹,

Kordeva²

2024

PJDV

View full text Add to dashboard Cite

show abstract

Dysplastic Nevus and BCC development after antihypertensive therapy with Valsartan and Hydrochlorothiazide!?

Abstract: The need of big, longitudinal studies in this subject is constantly increasing. They should confirm or reject our statement, because the simultaneous manifestation of two events does not necessarily mean they are causally related.

Cited by 1 publication

References 7 publications

Giant BCC of the scalp after telmisartan/amlodipine: potential role of nitrosamine contamination as main cause for skin cancer development

Giant BCC of the scalp after telmisartan/amlodipine: potential role of nitrosamine contamination as main cause for skin cancer development

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