Dysregulated serum lipid profile and its correlation to disease activity in young female adults diagnosed with systemic lupus erythematosus: a cross-sectional study

Abstract

Background: Recent studies showed that dyslipidemia could be a critical factor in the progression of cardiovascular disease in systemic lupus erythematosus (SLE). The aim of the present study was to describe the relationship between serum lipid profile and SLE disease activity in young female adults with SLE. Methods: Seventy-one female subjects diagnosed with SLE aged 20~30 years were enrolled. Serum lipid profile including TC, TG, HDL-C, LDL-C, VLDL-C, Apo A, Apo B, and Apo E were evaluated between control and young female SLE patients. Univariate correlation analyses were performed to explore the correlation between serum lipid levels and SLE disease activity. Results: Our results showed that TG and VLDL-C levels were significantly increased in young female SLE as compared to control, with TC, HDL-C, LDL-C, Apo A, and Apo B significantly reduced. Meanwhile, univariate correlation analyses showed negative correlations between SLE disease activity index and HDL-C, LDL-C, Apo A, and Apo B; with positive correlations between SLE disease activity index and TG and VLDL-C. Conclusion: Serum lipid profile was significantly dysregulated in young female SLE patients. Moreover, SLE disease activity was correlated to the serum lipid levels, supporting the notion that the young patients with SLE might also have a higher risk of cardiovascular disease.

Association of Triglycerides With Systemic Lupus Erythematosus-associated Kidney Injury

“…Triglyceride, HDL, LDL, LDH, AST/ALT, α-HBDH, total cholesterol, haemoglobin, PDW, haematocrit, RDW and LYM were extracted from the laboratory indicators, and all of them were signi cantly different between patients with SLE and healthy controls. These results are consistent with previous studies [19][20][21][22][23][24][25][26] .To our knowledge, we rst found that triglyceride, LDH and α-HBDH were signi cantly higher, whilehaemoglobin and haematocrit were signi cantly lower in the group of patients with SLE with kidney injury. We demonstrated that elevated triglycerides may be an independent risk factor for SLE-related kidney injury by logistic regression analysis and SLE patients with SLE-related kidney injury occur mainly around at 34 years of age.…”

PGLYRP2 as a novel biomarker for the activity and lipid metabolism of systemic lupus erythematosus

“…The ratio of Apo-B to Apo-A1 (Apo-B/A1) is usually detected to predict atherosclerosis in clinical practice. A previous study has identified that SLEDAI is negatively correlated to HDL-c, LDL-c, Apo-A1 and Apo-B, but positively correlated to TG and VLDL-C in SLE patients [ 26 ]. Consistently, this study showed that SLEDAI was positively correlated to LDL-c, Apo-B and Apo-B/A1, but not to TG, HDL-c, Apo-A1 and IgA.…”

Sphingolipids and Diagnosis, Prognosis, and Organ Damage in Systemic Lupus Erythematosus

“…HDL is known to be protective against atherosclerosis; however, this concept does not hold up in the context of SLE. Changes in HDL, LDL, and total cholesterol have been recently evaluated as potential biomarkers of SLE, specifically HDL levels and changes in its protective function (31). In a cross-sectional study, the lipid profile of 71 young (20-30 years old) women with SLE and age matched controls were studied with the goal of describing the relationship of lipids with disease severity (31).…”

“…Changes in HDL, LDL, and total cholesterol have been recently evaluated as potential biomarkers of SLE, specifically HDL levels and changes in its protective function (31). In a cross-sectional study, the lipid profile of 71 young (20-30 years old) women with SLE and age matched controls were studied with the goal of describing the relationship of lipids with disease severity (31). Triglycerides and VLDL cholesterol levels were significantly increased in the SLE group, while levels of total cholesterol, HDL cholesterol, LDL cholesterol, Apo A, and Apo B were significantly reduced.…”

“…Disease severity correlated with the level of dyslipidemia. This allowed the authors to surmise that disease severity also correlated with the risk for atherosclerosis (31). In a study conducted by McMahon et al (32), the functional ability of HDL to prevent the oxidation of LDL was determined in 154 SLE patients.…”