Dysregulation of dopamine and pathology of prefrontal neurons: neuroimaging studies in schizophrenia and related animal models

Bertolino, Alessandro

doi:10.1017/s1121189x00008150

Cited by 4 publications

(1 citation statement)

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“…Some studies related a hypo-metabolic activity in prefrontal cortex [40] and alterations in dopa-minergic, cholinergic and serotoninergic neurotransmission [41]. We can observe in this study that the CK activity is increased in all brain structures tested, suggesting that 25 and 50 mg/ kg may cause the increase of the energy demand to supply the necessity of ATP.…”

Section: Discussionsupporting

confidence: 53%

A Rodent Model of Schizophrenia Reveals Increase in Creatine Kinase Activity with Associated Behavior Changes

Canever

Oliveira

Luca

et al. 2010

Oxidative Medicine and Cellular Longevity

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Schizophrenia is a debilitating mental disorder characterized by positive (delusions, hallucinations, disorganized speech) and negative (affective flattering, avolition and social withdrawal) symptoms as well as cognitive deficits. The frequency, severity and topography characterize the disorder as heterogeneous, the pathophysiology of schizophrenia is poorly understood. Sub-anesthetic doses of ketamine produce hyperactivity, stereotypy and abnormal social interaction and it is used as a model of schizophrenia. In this study, we induced an animal model by acute sub-anesthetic doses of ketamine and tested different behavioral parameters. We also evaluated the activity of creatine kinase (CK) in brain of rats treated with ketamine. Our results demonstrated that administration of 10, 25 and 50 mg/kg of ketamine induced an increase of covered distance in habituated and non-habituated rats to the behavioral apparatus. Ketamine administration induced significant social deficits and stereotypic behavioral in all doses tested. Finally we evaluated the effect of different doses of ketamine on creatinine kinase (CK) activity and we observed that CK activity is increased inspecific regions of the brain. Our study suggests that our animal model may be used as a model of schizophrenia and that cerebral energy metabolism might be altered in the brain of schizophrenic patients, probably leading to alterations that might be involved in the pathogenesis of schizophrenia.

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Section: Discussionsupporting

confidence: 53%