Dysregulation of GAS5 and OIP5-AS1 lncRNAs in periodontitis

Sayad, Arezou; Ghafouri‐Fard, Soudeh; Sadeghpour, Saba; Mirzajani, Sara; Taheri, Mohammad; Arsang‐Jang, Shahram; Raji, Mojgan Ahmadzadeh; Houshmand, Behzad; Amid, Reza; Gholami, Leila; Shams, Bahareh

doi:10.1016/j.genrep.2020.100712

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…Studies have attempted to determine the molecular mechanisms behind the manifestation of periodontitis via lncRNAs that are known to regulate inflammatory processes. OIP5‐AS1 is one such lncRNA, where its levels are reduced in tissues with periodontitis compared to healthy tissues 75,76 . It has also been found that expression of OIP5‐AS1 is significantly lower in female periodontitis patients relative to their male counterparts 76 .…”

Section: A Single Lncrna: a Myriad Diseasesmentioning

confidence: 99%

“…OIP5‐AS1 is one such lncRNA, where its levels are reduced in tissues with periodontitis compared to healthy tissues 75,76 . It has also been found that expression of OIP5‐AS1 is significantly lower in female periodontitis patients relative to their male counterparts 76 . It is hypothesised that the downregulation of OIP5‐AS1 allows for a subsequent rise in HuR activity, which stimulates the inflammatory responses that result in periodontitis 76 …”

Section: A Single Lncrna: a Myriad Diseasesmentioning

confidence: 99%

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Long non‐coding RNA OIP5‐AS1 (Cyrano): A context‐specific regulator of normal and disease processes

Wooten

Smith

2022

Clinical & Translational Med

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Long non‐coding (lnc) RNAs have been implicated in a plethora of normal biological functions, and have also emerged as key molecules in various disease processes. OIP5‐AS1, also commonly known by the alias Cyrano, is a lncRNA that displays broad expression across multiple tissues, with significant enrichment in particular contexts including within the nervous system and skeletal muscle. Thus far, this multifaceted lncRNA has been found to have regulatory functions in normal cellular processes including cell proliferation and survival, as well as in the development and progression of a myriad disease states. These widespread effects on normal and disease states have been found to be mediated through context‐specific intermolecular interactions with dozens of miRNAs and proteins identified to date. This review explores recent studies to highlight OIP5‐AS1's contextual yet pleiotropic roles in normal homeostatic functions as well as disease oetiology and progression, which may influence its utility in the generation of future theranostics.

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Section: A Single Lncrna: a Myriad Diseasesmentioning

confidence: 99%

Section: A Single Lncrna: a Myriad Diseasesmentioning

confidence: 99%

Long non‐coding RNA OIP5‐AS1 (Cyrano): A context‐specific regulator of normal and disease processes

Wooten

Smith

2022

Clinical & Translational Med

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Genetic susceptibility for periodontitis with special focus on immune-related genes: A concise review

et al. 2020

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Altered expression of STAT genes in periodontitis

Gholami

Movafagh

Badrlou

et al. 2021

HAB

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Signal Transducer and Activator of Transcription (STAT) pathway is functionally located downstream of Janus kinases proteins and can integrate signals from diverse pathways, thus regulating several aspects of immune responses. Although contribution of STAT proteins in the pathogenesis of several inflammatory conditions has been confirmed, their role in the development of periodontitis has been less appraised. Thus, we assessed levels of STAT transcripts in the periodontal tissues and circulation of affected individuals compared with the corresponding controls. Expression of STAT1 was remarkably lower in tissues samples of patients compared with control tissues (Ratio of mean expression (RME) = 0.15, SE = 0.99, P value = 0.01). Expression of STAT3 was lower in total periodontitis tissues compared with total control tissues (RME = 0.20, SE = 0.95, P value = 0.02). Expression of STAT6 was higher in total periodontitis tissues compared with total control tissues (RME = 0.5.38, SE = 0.74, P value < 0.001). Expressions of other STAT genes were statistically similar in tissues obtained from cases and controls. Moreover, blood levels of all STAT genes were statistically similar between patients and controls. Correlation analysis demonstrated significant correlations between tissues levels of individual STAT genes as well as between their blood levels. However, tissue and blood levels of each STAT gene were not correlated. The current investigation potentiates the role of certain STAT genes in the development of this immune-related condition and warrants functional assays to clarify the mechanism.

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Dysregulation of GAS5 and OIP5-AS1 lncRNAs in periodontitis

Cited by 3 publications

References 19 publications

Long non‐coding RNA OIP5‐AS1 (Cyrano): A context‐specific regulator of normal and disease processes

Long non‐coding RNA OIP5‐AS1 (Cyrano): A context‐specific regulator of normal and disease processes

Genetic susceptibility for periodontitis with special focus on immune-related genes: A concise review

Altered expression of STAT genes in periodontitis

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