Dysregulation of gastric H,K-ATPase by cigarette smoke extract

Hammadi, Muna

doi:10.3748/wjg.15.4016

Cited by 8 publications

(7 citation statements)

References 39 publications

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“…A somewhat speculative connection is offered by recent work, which showed cigarette smoke extracts cause an increase in the amount of H + /K + ATPase in the stomach [28]. It is unclear — and worth testing — whether ATP4A and ATP4B are expressed in the heart.…”

Section: Resultsmentioning

confidence: 99%

Prediction of gene-phenotype associations in humans, mice, and plants using phenologs

et al. 2013

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BackgroundPhenotypes and diseases may be related to seemingly dissimilar phenotypes in other species by means of the orthology of underlying genes. Such “orthologous phenotypes,” or “phenologs,” are examples of deep homology, and may be used to predict additional candidate disease genes.ResultsIn this work, we develop an unsupervised algorithm for ranking phenolog-based candidate disease genes through the integration of predictions from the k nearest neighbor phenologs, comparing classifiers and weighting functions by cross-validation. We also improve upon the original method by extending the theory to paralogous phenotypes. Our algorithm makes use of additional phenotype data — from chicken, zebrafish, and E. coli, as well as new datasets for C. elegans — establishing that several types of annotations may be treated as phenotypes. We demonstrate the use of our algorithm to predict novel candidate genes for human atrial fibrillation (such as HRH2, ATP4A, ATP4B, and HOPX) and epilepsy (e.g., PAX6 and NKX2-1). We suggest gene candidates for pharmacologically-induced seizures in mouse, solely based on orthologous phenotypes from E. coli. We also explore the prediction of plant gene–phenotype associations, as for the Arabidopsis response to vernalization phenotype.ConclusionsWe are able to rank gene predictions for a significant portion of the diseases in the Online Mendelian Inheritance in Man database. Additionally, our method suggests candidate genes for mammalian seizures based only on bacterial phenotypes and gene orthology. We demonstrate that phenotype information may come from diverse sources, including drug sensitivities, gene ontology biological processes, and in situ hybridization annotations. Finally, we offer testable candidates for a variety of human diseases, plant traits, and other classes of phenotypes across a wide array of species.

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Section: Resultsmentioning

confidence: 99%

Prediction of gene-phenotype associations in humans, mice, and plants using phenologs

et al. 2013

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“…Enhanced secretion of acid and pepsin by parietal and zymogenic cells may contribute to damage of the mucous layer ( 1 ). Smoking contributes to ulcer formation by upregulating the production of the proton pump and, therefore, acid secretion ( 19 ). Damage to the mucous layer may lead to peeling of the surface epithelium and exposure of the endothelial cells of capillaries in the underlying connective tissue.…”

Section: Gastric Ulcermentioning

confidence: 99%

Potential role of probiotics in the management of gastric ulcer

Khoder

Al-Menhali

Al-Yassir

et al. 2016

Experimental and Therapeutic Medicine

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Gastric ulcer is one of the most common chronic gastrointestinal diseases characterized by a significant defect in the mucosal barrier. Helicobacter pylori (H. pylori) infection and the frequent long-term use of non-steroidal anti-inflammatory drugs are major factors involved in gastric ulcer development. Acid inhibitors and antibiotics are commonly used to treat gastric ulcer. However, in the last few decades, the accumulating evidence for resistance to antibiotics and the side effects of antibiotics and acid inhibitors have drawn attention to the possible use of probiotics in the prevention and treatment of gastric ulcer. Probiotics are live microorganisms that when administered in adequate amounts confer health benefits on the host. Currently, the available experimental and clinical studies indicate that probiotics are promising for future applications in the management of gastric ulcers. This review aims to provide an overview of the general health benefits of probiotics on various systemic and gastrointestinal disorders with a special focus on gastric ulcer and the involved cellular and molecular mechanisms: i) Protection of gastric mucosal barrier; ii) upregulation of prostaglandins, mucus, growth factors and anti-inflammatory cytokines; iii) increased cell proliferation to apoptosis ratio; and iv) induction of angiogenesis. Finally, some of the available data on the possible use of probiotics in H. pylori eradication are discussed.

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“…(Firmicutes) in the colon, with alteration in inflammatory gene expression. 231 These data highlight a possible role for CS in gut microbiome shaping with unknown consequences in the evolution of inflammation-related disorders such as IBD.…”

Section: Ibd Microbiome and Lifestyle Factorsmentioning

confidence: 89%

“…Among them, the following should be mentioned: epigenetic susceptibility, modulation of mucosal immune response, alterations in intestinal cytokine and eicosanoid levels, modification of gut permeability with consequent impaired clearance of pathogen alteration in the H þ /K þ -ATPase pump with consequential acidification of gastric contents, and ingestion of the bacteria present in cigarettes. [227][228][229][230]231,232 Human studies targeting selected bacterial groups have reported that smoking patients with active CD have increased abundances of Bacteroides and Prevotella 233 (both Bacteroidetes) and decreased Firmicutes to Bacteroidetes ratios. 60 Similar results were obtained in healthy CS controls, suggesting that the association may not be related to intestinal inflammation but may instead reflect the direct impact of CS on the microbiota.…”

Section: Ibd Microbiome and Lifestyle Factorsmentioning

confidence: 99%

Exploring the microbiome in health and disease

Scotti

Boué

Sasso

et al. 2017

Toxicology Research and Application

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The analysis of human microbiome is an exciting and rapidly expanding field of research. In the past decade, the biological relevance of the microbiome for human health has become evident. Microbiome comprises a complex collection of microorganisms, with their genes and metabolites, colonizing different body niches. It is now well known that the microbiome interacts with its host, assisting in the bioconversion of nutrients and detoxification, supporting immunity, protecting against pathogenic microbes, and maintaining health. Remarkable new findings showed that our microbiome not only primarily affects the health and function of the gastrointestinal tract but also has a strong influence on general body health through its close interaction with the nervous system and the lung. Therefore, a perfect and sensitive balanced interaction of microbes with the host is required for a healthy body. In fact, growing evidence suggests that the dynamics and function of the indigenous microbiota can be influenced by many factors, including genetics, diet, age, and toxicological agents like cigarette smoke, environmental contaminants, and drugs. The disruption of this balance, that is called dysbiosis, is associated with a plethora of diseases, including metabolic diseases, inflammatory bowel disease, chronic obstructive pulmonary disease, periodontitis, skin diseases, and neurological disorders. The importance of the host microbiome for the human health has also led to the emergence of novel therapeutic approaches focused on the intentional manipulation of the microbiota, either by restoring missing functions or eliminating harmful roles. In the present review, we outline recent studies devoted to elucidate not only the role of microbiome in health conditions and the possible link with various types of diseases but also the influence of various toxicological factors on the microbial composition and function.

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Dysregulation of gastric H,K-ATPase by cigarette smoke extract

Cited by 8 publications

References 39 publications

Prediction of gene-phenotype associations in humans, mice, and plants using phenologs

Prediction of gene-phenotype associations in humans, mice, and plants using phenologs

Potential role of probiotics in the management of gastric ulcer

Exploring the microbiome in health and disease

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