Dysregulation of miR484-TUSC5 axis takes part in the progression of hepatocellular carcinoma

Wang, Shanzong; Wang, Weijuan; Han, Xiaochen; Wang, Youli; Ge, Yunzhen; Tan, Zhen

doi:10.1093/jb/mvz034

Cited by 13 publications

(11 citation statements)

References 28 publications

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“…It also has been reported that miR-484 was highly specific for prostate cancer, which could make it act as a prostate cancer screening biomarker [35]. In hepatocellular carcinoma, miR-484 has an oncogenic role by targeting TUSC5 [36]. Moreover, miR-484 could act as the biomarker for many other cancers, including lung cancer, breast cancer, cervical cancer and colorectal cancer [15,16,37].…”

Section: Discussionmentioning

confidence: 97%

Downregulation of miR-484 is associated with poor prognosis and tumor progression of gastric cancer

Yao

et al. 2020

Diagn Pathol

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Background: Gastric cancer is one of the most common cancers leading to high cancer mortality. MicroRNA-484 (miR-484) has been evaluated as a biomarker for various types of cancers. The subject of this study is to investigate the functional role of miR-484 in gastric cancer. Methods: The expression of miR-484 in gastric cancer was analyzed by quantitative real-time polymerase chain reaction (qRT-PCR) assay. Kaplan-Meier survival and Cox regression analyses were employed to explore the prognostic significance of miR-484 in gastric cancer. The functional role of miR-484 in gastric cancer was determined by CCK-8 and Transwell assays. Results: The results showed that miR-484 was significantly downregulated in gastric cancer tissues and cell lines. The downregulation of miR-484 was closely related to differentiation, lymph node metastasis, TNM stage, and poor prognosis. Cox regression analyses demonstrated that miR-484 was an independent prognosis indicator for gastric cancer patients. Additionally, the downregulation of miR-484 enhanced cell proliferation, migration, and invasion in gastric cancer cells. Conclusion: These data demonstrated that miR-484 can serve as a potential prognostic biomarker and therapeutic target for gastric cancer and it may be involved in the progression of gastric cancer.

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Section: Discussionmentioning

confidence: 97%

Downregulation of miR-484 is associated with poor prognosis and tumor progression of gastric cancer

Yao

et al. 2020

Diagn Pathol

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“…31 In tumours, the expression of some miRNAs was inhibited, and the binding of miRISC to the 3′-UTR of target genes was reduced, resulting in the release of translation inhibition of downstream target genes. It has been reported that miR-484 can target the expression of Apaf-1, ZEB1, SMAD2 and TUSC5, [13][14][15]32 thus affecting the occurrence and development of tumours. Bioinformatics software is an important tool for predicting target genes of miRNAs.…”

Section: Discussionmentioning

confidence: 99%

MiR‐484 suppressed proliferation, migration, invasion and induced apoptosis of gastric cancer via targeting CCL‐18

Liu¹,

Li²

2020

Int J Experimental Path

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Gastric cancer is a common high-incidence malignant gastrointestinal form of cancer that poses serious threat to human life. At present, there are about 980 000 new cases and 730 000 deaths worldwide each year, and both morbidity and mortality are the third highest among malignant tumours. 1 In China, the incidence and mortality of gastric cancer rank it first in malignant tumours of digestive system and second in malignant tumours, and the mortality from gastric cancer accounts for 23.18% of all malignant tumours. 2 Currently, endoscopy, X-ray, B-mode ultrasonography, CT, MRI and exfoliative cytology are the main methods for clinic diagnosis of gastric cancer, but these diagnostic methods have some deficiencies when trying to make an early diagnosis of gastric cancer. 3 This lack of specific and sensitive screening indicators is the most important factor in hampering early diagnosis of gastric cancer, and this leads to the fact that the majority of patients with gastric cancer are in the middle and late stages at the time of clinical diagnosis, ultimately resulting in poor clinical efficacy of treatment and

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“…This shows that miR-484 may participate in NSCLC development. It is worth noting that miR-484 expression differs in different cancers: in liver cancer, miR-484 expression is significantly upregulated, but it is significantly decreased in gastric cancer [25,26]. This shows that miR-484 has diverse roles that are determined by the type of tumor, miRNA localization, and its target genes.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-484 promotes cell migration and invasion in non-small cell lung cancer

Yang

Gong

et al. 2020

Preprint

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Background Lung cancer is one of the most common causes of cancer-related deaths in the world, and non-small cell lung cancer (NSCLC) accounts for 85% of it. Studies have reported that microRNA-484 (miR-484) plays an important regulatory role in carcinogenesis and cancer development. Methods 25 clinical NSCLC samples were collected for microRNA array. The funvtion of miR-484 was investigated through Transwell and Mitgration assays. The expression levers of epithelial-mesenchymal transition (EMT) related factors were assessed by Western blot. Results miR-484 was up-regulated in tissues from NSCLC patients relative to tumor-adjacent normal tissues. Knocking-down miR-484 expression in A549 cells significantly suppressed tumor cell invasion and migration, suppressed epithelial-mesenchymal transition (EMT) process by increasing the expression of E-cadherin, and decreasing the expression of N-cadherin, vimentin, and MMP2. Upregulation of miR-484 expression in BEAS-2B normal lung epithelial cells significantly promoted tumor cell invasion and migration, decreased E-cadherin expression levels, and increased N-cadherin, vimentin, and MMP2 expression levels Conclusion miR-484 can promote tumor cell invasion and migration in NSCLC and may be a new target for NSCLC treatment.

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Dysregulation of miR484-TUSC5 axis takes part in the progression of hepatocellular carcinoma

Cited by 13 publications

References 28 publications

Downregulation of miR-484 is associated with poor prognosis and tumor progression of gastric cancer

Downregulation of miR-484 is associated with poor prognosis and tumor progression of gastric cancer

MiR‐484 suppressed proliferation, migration, invasion and induced apoptosis of gastric cancer via targeting CCL‐18

MicroRNA-484 promotes cell migration and invasion in non-small cell lung cancer

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