Dysregulation of Mirna-146A Contributes to the Development of Lupus Nephritis Via Targeting of
            <i>TRAF6</i>

Wu, Shupeng; Wang, Jing; Li, Fang

doi:10.2217/pme-2016-0065

Cited by 6 publications

(5 citation statements)

References 32 publications

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“…Contradictory, Alemán-Ávila et al showed significant variations in genotypes distribution of rs2910164 SNP between Mexican SLE patients and controls [ 4 ]. Ambivalent to the current study, Wu et al observed that Chinese patients with lupus nephritis [LN] increased the frequency of the C allele against patients without nephritis [ 43 ]. Also, they documented that the C allele and genotype carriers were associated with LN risk while the G allele worked as a protective factor against increasing the disease complication [ 43 ].…”

Section: Discussioncontrasting

confidence: 88%

“…Ambivalent to the current study, Wu et al observed that Chinese patients with lupus nephritis [LN] increased the frequency of the C allele against patients without nephritis [ 43 ]. Also, they documented that the C allele and genotype carriers were associated with LN risk while the G allele worked as a protective factor against increasing the disease complication [ 43 ]. Inconsistent with our study, Labib et al [ 28 ] found significant differences in alleles and genotypes of rs2910164 SNP between Egyptian SLE patients and controls.…”

Section: Discussioncontrasting

confidence: 88%

“…In agreement, rs2910164 SNP affects miR-146a expression in LN patients where the carrier harboring CC genotype had low miR-146a expression than CG and GG. Also, they documented that the minor G allele might be a protective factor from LN [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

“…SLE influences human health and quality of life [ [3] , [4] , [5] ]. The overall incidence and prevalence of SLE have increased from 1.4 to 21.9% and from 7.4 to 159.4 cases per 100,000 people, respectively [ [5] , [6] , [7] , [8] ]. The disease incidence is higher in females than in males, with ten times (the ratio is 9:1) in reproductive age [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

mir-146a genetic polymorphisms in systemic lupus erythematosus patients: Correlation with disease manifestations

El-Akhras

Ali

El‐Masry

et al. 2022

Non-coding RNA Research

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Section: Discussioncontrasting

confidence: 88%

Section: Discussioncontrasting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

mir-146a genetic polymorphisms in systemic lupus erythematosus patients: Correlation with disease manifestations

El-Akhras

Ali

El‐Masry

et al. 2022

Non-coding RNA Research

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“…[23][24][25][26] Interestingly, in vitro studies have shown that miR-146a may regulate the IL-1 receptor associated kinase 1 (IRAK-1) and TRAF6 on TLR-4 signaling pathway through negative feedback and may suppress NF-kB activity so as to further reduce the expression of proinflammatory factors, such as TNF-a, IL-6, and IL-1b, [23][24][25] thereby inhibiting the activation of small keratinocytes and reducing the pathological damage caused by their activation. 27 Prior report has highlighted that induction of human miR-146a (has-miR-146a) regulates innate immune response by the mean of targeting TRAF6 and IRAK-1 genes 9. 24 Notably, the sequences of miR-146a, TRAF6, and IRAK-1 exhibit a high degree of nucleotide identity.…”

Section: Discussionmentioning

confidence: 99%

miR-146a alleviates the apoptosis of hippocampal neurons induced by microglia activation via targeting TRAF6

Jia

Liu

Han³

et al. 2020

Hum Exp Toxicol

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Objective: To identify the role of miR-146a and tumor necrosis factor receptor-associated factor 6 (TRAF6) for improving the apoptosis of hippocampal neurons induced by microglia activation. Methods: Mouse microglial cell line (BV2 cell) was employed and treated with lipopolysaccharide. Mouse hippocampal nerve cell line (HT22 cell) was then grown in BV2 conditioned medium, and miR-146a overexpression and silencing cell lines were constructed. CCK8 and clone formation test were utilized to evaluate the proliferation ability of the transfected cells, and the level of inflammatory factors was measured by ELISA. Apoptosis was determined extensively by flow cytometry. The apoptosis-related protein and TRAF6 protein expressions were verified by Western blot. TRAF6 was identified to be the target gene of miR-146a based on double Luciferase Report. Finally, both TRAF6 and miR-146a were used to treat HT22 cells and the above indexes were detected repeatedly. Results: Interleukin (IL)-1β, tumor necrosis factor-α, and IL-6 expressions in BV2 cells increased significantly. miR-146a overexpression distinctly increased the cell proliferation ability and B-cell lymphoma-2 expression ((Bcl-2, p < 0.05); meanwhile, the apoptosis rate of cells, apoptosis-related proteins (Bcl-2 associated X and cleaved caspase-3), and TRAF6 gene and protein expressions were significantly decreased ( p < 0.05). However, these above results were reversed for miR-146a silence. There is a targeting relationship between miR-146a and TRAF6. Silencing TRAF6 gene can promote HT22 cells’ proliferation and inhibit apoptosis. The effect of miR-146a on HT22 cells was reversed by adding TRAF6 mimics to miR-146a overexpression cells. Conclusion: miR-146a can inhibit the apoptosis of hippocampal neurons caused by microglia activation via targeting TRAF6 and down-regulating its expression.

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Roles of noncoding RNA in allergic rhinitis

Zhao,

Yang,

Wang

et al. 2024

Int Forum Allergy Rhinol

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BackgroundAllergic rhinitis (AR) is one of the most common respiratory noninfectious diseases and chronic inflammatory diseases, the incidence of which has been increasing in recent years. The main pathological characteristics of AR are repeated inflammation, airway hyperreactivity, mucus hypersecretion, and reversible airway obstruction due to inflammatory cell response. AR occurrence is associated with various factors, including those of genetic and environmental origins. Noncoding RNAs (ncRNAs) are a group of RNA molecules that cannot be converted into polypeptides. The three main categories of ncRNAs include microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs). NcRNAs play a crucial role in controlling gene expression and contribute to the development of numerous human diseases.MethodsArticles are selected based on Pubmed's literature review and the author's personal knowledge. The largest and highest quality studies were included. The search selection is not standardized. Several recent studies have indicated the relationship of ncRNAs with the development of respiratory allergic diseases. NcRNAs, including miRNAs, lncRNAs, and circRNAs, are important gene expression regulatory factors. We review the expression and function of ncRNAs in AR, their role as disease biomarkers, and their prospective applicability in future research and clinically. We also discuss interactions between ncRNAs and their influence on AR comprehensively, these interactions are essential for determining the underlying pathological mechanisms further and discovering new drug therapeutic targets.ResultsNcRNAs can be used as biomarkers for early AR diagnosis, disease surveillance and prognosis assessment. Various categories of ncRNAs play distinct yet interconnected roles and actively contribute to intricate gene regulatory networks. They are also therapeutic targets and biomarkers in other allergic diseases.ConclusionThis article demonstrates ncRNAs have a wide range of applications in AR treatment. The database covers three key areas: miRNAs, lncRNAs, and circRNAs. Additionally, potential avenues for future research to facilitate the practical application of ncRNAs as therapeutic targets and biomarkers will be explore. With further research and technological development, ncRNAs may provide additional innovative, effective solutions for AR treatment.

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Dysregulation of Mirna-146A Contributes to the Development of Lupus Nephritis Via Targeting of TRAF6

Abstract: Rs2910164 is associated with the risk of LN and could function as a therapeutic target of the disease.

Cited by 6 publications

References 32 publications

mir-146a genetic polymorphisms in systemic lupus erythematosus patients: Correlation with disease manifestations

mir-146a genetic polymorphisms in systemic lupus erythematosus patients: Correlation with disease manifestations

miR-146a alleviates the apoptosis of hippocampal neurons induced by microglia activation via targeting TRAF6

Roles of noncoding RNA in allergic rhinitis

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