Dysregulation of Porphyromonas gingivalis Agmatine Deiminase Expression in Alzheimer’s Disease
Asma Hamdi,
Sana Baroudi,
Alya Gharbi
et al.
Abstract:Background:
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder,
with a significant burden on global health. AD is characterized by a progressive cognitive decline
and memory loss. Emerging research suggests a potential link between periodontitis, specifically
the presence of oral bacteria such as Porphyromonas gingivalis (P. gingivalis), and AD progression.
P. gingivalis produces an enzyme, Agmatine deiminase (AgD), which converts agmatine
to N-carbamoyl putrescine (NCP), serving as a pr… Show more
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