Dysregulation of Pulmonary Responses in Severe COVID-19

Wu, Dandan; Yang, Xuexian O.

doi:10.1101/2020.10.23.353177

Cited by 2 publications

(2 citation statements)

References 36 publications

(44 reference statements)

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“…This study further established the key role of TLR7 signalling in the host defence against SARS-CoV-2 infection. It has also been demonstrated in nasal tissue, bronchoalveolar lavage and peripheral blood mononuclear cells extracted from COVID-19 patients that expression levels of TLR7 correlated with disease severity [92,93].…”

Section: A Novel Inborn Error Predisposing To Severe Covid-19: X-link...mentioning

confidence: 98%

Clinical implications of host genetic variation and susceptibility to severe or critical COVID-19

et al. 2022

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Since the start of the coronavirus disease 2019 (COVID-19) pandemic, important insights have been gained into virus biology and the host factors that modulate the human immune response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 displays a highly variable clinical picture that ranges from asymptomatic disease to lethal pneumonia. Apart from well-established general risk factors such as advanced age, male sex and chronic comorbidities, differences in host genetics have been shown to influence the individual predisposition to develop severe manifestations of COVID-19. These differences range from common susceptibility loci to rare genetic variants with strongly predisposing effects, or proven pathogenic variants that lead to known or novel inborn errors of immunity (IEI), which constitute a growing group of heterogeneous Mendelian disorders with increased susceptibility to infectious disease, auto-inflammation, auto-immunity, allergy or malignancies. The current genetic findings point towards a convergence of common and rare genetic variants that impact the interferon signalling pathways in patients with severe or critical COVID-19. Monogenic risk factors that impact IFN-I signalling have an expected prevalence between 1 and 5% in young, previously healthy individuals (<60 years of age) with critical COVID-19. The identification of these IEI such as X-linked TLR7 deficiency indicates a possibility for targeted genetic screening and personalized clinical management. This review aims to provide an overview of our current understanding of the host genetic factors that predispose to severe manifestations of COVID-19 and focuses on rare variants in IFN-I signalling genes and their potential clinical implications.

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Section: A Novel Inborn Error Predisposing To Severe Covid-19: X-link...mentioning

confidence: 98%

Clinical implications of host genetic variation and susceptibility to severe or critical COVID-19

et al. 2022

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“…10,11 Researchers from China are optimistic about the virus prevention and control, as the proportion of severe and critical COVID-19 cases among all con rmed cases in China has dropped signi cantly from 16.47% in 2020 to 0.18% by December 5, 2022. 12 However, other researchers have a more cautious outlook, which emphasizes the importance of remaining vigilant as the outbreak is still ongoing. 13 On Dec 7, 2022, the Chinese government announced ten measures indicating the end of the zero COVID policy.…”

Section: Introductionmentioning

confidence: 99%

Changes in the spectrum of ocular disease during the COVID-19 pandemic in late 2022 in the Hubei Province

Bao,

Chen,

Zheng

et al. 2024

Preprint

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Purpose We aimed to investigate changes in the ocular disease spectrum during the coronavirus disease-2019 (COVID-19) pandemic in late 2022 in the Hubei Province. Methods This retrospective observational study was conducted in two parts. The first part involved collecting COVID-19-related information from residents of Hubei Province during the COVID-19 pandemic through an online questionnaire survey. The second part involved extracting electronic medical records from ophthalmology outpatient departments at two hospitals in Hubei Province during the pandemic and epidemic prevention and control periods, analyzing changes in the spectrum of ocular diseases. Results In the first part，31.65% of patients with systemic symptoms of COVID-19 experienced ocular discomforts. The most common ocular symptoms were eye fatigue, ocular pain and dry eye. In the second part, 76.5% of patients who visited the ophthalmic clinic had COVID-19-related systemic symptoms during pandemic period. The proportion of ornea/keratitis, glaucoma/acute angle-closure glaucoma (AACG) and vitreoretinal disease/retinal vein obstruction (RVO)/acute macular neuroretinalpathy (AMN) increased markedly during pandemic period. Additionally, the number of patients under 18 years and over 60 years in pandemic perioddecreased significantly. Conclusion The COVID-19 pandemic has led to certain changes in the spectrum of ocular disease, which warrants the attention of ophthalmologists.

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Dysregulation of Pulmonary Responses in Severe COVID-19

Cited by 2 publications

References 36 publications

Clinical implications of host genetic variation and susceptibility to severe or critical COVID-19

Clinical implications of host genetic variation and susceptibility to severe or critical COVID-19

Changes in the spectrum of ocular disease during the COVID-19 pandemic in late 2022 in the Hubei Province

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