Dysregulation of Regional Endogenous Opioid Function in Borderline Personality Disorder

Prossin, Alan R.; Love, Tiffany M.; Koeppe, Robert A.; Zubieta, Jon Kar; Silk, Kenneth R.

doi:10.1176/appi.ajp.2010.09091348

Cited by 144 publications

(104 citation statements)

References 54 publications

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“…These results are consistent with previous human postmortem (Zhang et al, 2005) and neuroimaging studies in alcohol dependence (Weerts et al, 2013), tobacco smokers (Ray et al, 2011), and the role of m-opioid receptors in the suppression of stress, pain and negative emotional states (Prossin et al, 2010;Zubieta et al, 2003b;Zubieta et al, 2001). Similar reductions (NAc, AMY, and dorsal ACC) have also been observed in patients with fibromyalgia (Harris et al, 2007), a persistent pain syndrome frequently comorbid with mood disturbances.…”

Section: Discussionsupporting

confidence: 91%

Effects of the Mu Opioid Receptor Polymorphism (OPRM1 A118G) on Pain Regulation, Placebo Effects and Associated Personality Trait Measures

Peciña

Love

Stohler

et al. 2014

Neuropsychopharmacol

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133

106

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Mu-opioid receptors (MOPRs) are critically involved in the modulation of pain and analgesia, and represent a candidate mechanism for the development of biomarkers of pain conditions and their responses to treatment. To further understand the human implications of genetic variation within the opioid system in pain and opioid-mediated placebo responses, we investigated the association between the functional single-nucleotide polymorphism (SNP) in the m-opioid receptor gene (OPRM1), A118G, and psychophysical responses, personality traits, and neurotransmitter systems (dopamine (DA), opioid) related to pain and placebo analgesia. OPRM1 G carriers, compared with AA homozygotes, showed an overall reduction of baseline m-opioid receptor availability in regions implicated in pain and affective regulation. In response to a sustained painful stimulus, we found no effect of A118G on pain-induced endogenous opioid release. Instead, AA homozygotes showed a blunted DA response in the nucleus accumbens (NAc) in response to the pain challenge. After placebo administration, G carriers showed more pronounced mood disturbances and lower placebo-induced m-opioid system activation in the anterior insula (aINS), the amygdala (AMY), the NAc, the thalamus (THA), and the brainstem, as well as lower levels of DA D 2/3 activation in the NAc. At a trait level, G carriers reported higher NEO-Neuroticism scores; a personality trait previously associated with increased pain and lower placebo responses, which were negatively correlated with baseline m-opioid receptor availability in the aINS and subgenual anterior cingulate cortex (sgACC). Our results demonstrate that the A118G OPRM1 polymorphism contributes to interindividual variations in the function of neurotransmitters responsive to pain (endogenous opioid and dopamine), as well as their regulation through cognitive-emotional influences in the context of therapeutic expectations, the so-called placebo effect. These effects are relevant to human vulnerability to disease processes where these neurotransmitters have a role, such as persistent pain, mood, and substance use disorders, and responses to their treatments. Neuropsychopharmacology (2015) 40, 957-965;

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Section: Discussionsupporting

confidence: 91%

Effects of the Mu Opioid Receptor Polymorphism (OPRM1 A118G) on Pain Regulation, Placebo Effects and Associated Personality Trait Measures

Peciña

Love

Stohler

et al. 2014

Neuropsychopharmacol

Self Cite

133

106

View full text Add to dashboard Cite

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“…The medial frontal cortex, implicated in cognitive control and regulation of emotions (8), has also been a target of BPD studies, and although it has not been reported to be significant in whole-brain morphometric comparisons, it has been found to be abnormal in studies of function (9)(10)(11)(12). The medial frontal cortex has extensive connections with the medial temporal cortex (including the amygdala and hippocampus) ensuring the cognitive-emotional control of behavior (13).…”

mentioning

confidence: 99%

Converging Medial Frontal Resting State and Diffusion-Based Abnormalities in Borderline Personality Disorder

Salvador

Vega

Pascual

et al. 2016

Biological Psychiatry

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BACKGROUND: The psychological profile of patients with borderline personality disorder (BPD), with impulsivity and emotional dysregulation as core symptoms, has guided the search for abnormalities in specific brain areas such as the hippocampal-amygdala complex and the frontomedial cortex. However, whole-brain imaging studies so far have delivered highly heterogeneous results involving different brain locations. METHODS: Functional resting-state and diffusion magnetic resonance imaging data were acquired in patients with BPD and in an equal number of matched control subjects (n 5 60 for resting and n 5 43 for diffusion). While mean diffusivity and fractional anisotropy brain images were generated from diffusion data, amplitude of low-frequency fluctuations and global brain connectivity images were used for the first time to evaluate BPD-related brain abnormalities from resting functional acquisitions. RESULTS: Whole-brain analyses using a p 5 .05 corrected threshold showed a convergence of alterations in BPD patients in genual and perigenual structures, with frontal white matter fractional anisotropy abnormalities partially encircling areas of increased mean diffusivity and global brain connectivity. Additionally, a cluster of enlarged amplitude of low-frequency fluctuations (high resting activity) was found involving part of the left hippocampus and amygdala. In turn, this cluster showed increased resting functional connectivity with the anterior cingulate. CONCLUSIONS: With a multimodal approach and without using a priori selected regions, we prove that structural and functional abnormality in BPD involves both temporolimbic and frontomedial structures as well as their connectivity. These structures have been previously related to behavioral and clinical symptoms in patients with BPD.

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“…Dada la variedad de agrupaciones sintomáticas que estos sujetos pueden presentar, la reacción ante los estímulos a los que nos referíamos en las líneas anteriores puede ser muy variada pero, inicialmente, podemos suponer un procesamiento de la información deficiente o incompleto en este grupo de pacientes. Se tiene conocimiento de una hipoactividad talámica en los pacientes con TLP (Prossin et al, 2010;De la Fuente et al, 1998) pero nada se conoce, a este respecto, en aquellos cuyo diagnóstico es el de TPNE. En el presente trabajo, mientras que se observan numerosas correlaciones en la actividad cerebral entre las diferentes regiones, la hipoactividad talámica correlaciona exclusivamente con la actividad de los lóbulos temporales, más específicamente con el lóbulo temporal derecho.…”

Section: Discussionunclassified

Full number: Volume 10, Number 2 / Número completo: Volumen 10, Número 2

2010.¹

2010

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CONSEJO EDITORIAL ObjetivosHealth and Addictions / Salud y Drogas tiene como fin promover la divulgación de resultados de investigación sobre las drogodependencias y otros trastornos adictivos en general, desde una aproximación amplia y pluridisciplinar, perfeccionar sus métodos y técnicas, fomentar una visión crítica y comprometida del fenómeno de la droga e impulsar la cooperación científica entre los investigadores, profesores, estudiosos y especialistas de la materia, desde el compromiso con la ética y los derechos humanos. En este sentido, Health and Addictions (Salud y Drogas) publica artículos sobre tratamiento, prevención y reinserción, así como estudios epidemiológicos, básicos y descriptivos sobre las conductas adictivas y la promoción e intervención en el ámbito de la Psicología de la Salud. FrecuenciaHealth and Addictions / Salud y Drogas se publica dos veces al año en versión impresa y electrónica, siendo la versión electrónica idéntica a la impresa. IdiomaEl idioma de publicación es el español, si bien ocasionalmente se aceptan artículos escritos en lenguas de la Unión Europea. SeparatasHealth and Addictions / Salud y Drogas envía a cada autor una carta de aceptación una vez superado el proceso de revisión. Así mismo, cada autor recibe una copia en pdf de su artículo y un ejemplar impreso del número en el que aparece su artículo. Copyright y permisosLos derechos de impresión y de reproducción por cualquier forma y medio son Health and Addictions / Salud y Drogas, que no rechazará cualquier petición razonable por parte de los autores para obtener el permiso de reproducción de sus contribuyentes. Papel Health and Addictions / Salud y Drogas EditorialReinventando las drogas José A. García del Castillo . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .7 originalEsSituación actual del consumo de sustancias en los adolescentes españoles: tabaco, alcohol, cannabis y otras drogas ilegales. Pilar Ramos Intervención psicológica en un trastorno adictivo desde el paradigma conductista radical Marcos López The validity of Transtheoretical Model through different psychological variables Zaira Morales, Consumo de drogas en población reclusa. Relación Diferencial entre abuso de sustancias psicoactivas y reincidencia Carolina Bringas Molleda, Trastornos de personalidad y adicción a opiáceos: un estudio descriptivo mediante SPECT en pacientes con patología dual César Mateu, Ana Benito, José Ferrer, Juan Barea, Eficacia de los programas de prevención escolar en función del agente preventivo: profesores vs expertos Mónica Gázquez Pertusa, Reinventing drug José A. García del Castillo . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .7 originalsCurrent situation of substance consumption in Spanish adolescents: tobacco, alcohol, cannabis and other illegal drugs. Pilar Ramos Psychological intervention in an addictive disorder from the radical behaviorist paradigm. Marcos López The validity of Transtheoretical Model through different psychological variabl...

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Dysregulation of Regional Endogenous Opioid Function in Borderline Personality Disorder

Cited by 144 publications

References 54 publications

Effects of the Mu Opioid Receptor Polymorphism (OPRM1 A118G) on Pain Regulation, Placebo Effects and Associated Personality Trait Measures

Effects of the Mu Opioid Receptor Polymorphism (OPRM1 A118G) on Pain Regulation, Placebo Effects and Associated Personality Trait Measures

Converging Medial Frontal Resting State and Diffusion-Based Abnormalities in Borderline Personality Disorder

Full number: Volume 10, Number 2 / Número completo: Volumen 10, Número 2

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