Dysregulation of the Autonomous Nervous System in Patients with Temporomandibular Disorder: A Pupillometric Study

Monaco, Annalisa; Cattaneo, R; Mesin, Luca; Ciarrocchi, Irma; Sgolastra, Fabrizio; Pietropaoli, Davide

doi:10.1371/journal.pone.0045424

Cited by 32 publications

(27 citation statements)

References 43 publications

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“…11 The literature reveals that psychiatric disorders and psychosocial stress increase sAA secretion; 17,18 in addition, adults with TMD may reveal impairments in the sympathetic-adrenergic component of the autonomic system, which may influence pain symptoms and catecholamine responses at rest and during stress. 19,20 Each risk factor for TMD needs to be considered to appropriately diagnose and plan the management strategies. 1 Stress is considered as an important factor in the onset and maintenance of musculoskeletal disorders, although little is known about the relationship between TMD, stress, and anxiety in children.…”

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confidence: 99%

Salivary stress biomarkers and anxiety symptoms in children with and without temporomandibular disorders

et al. 2017

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The etiology of temporomandibular disorders (TMD), which are considered as a heterogeneous group of psychophysiological disturbances, remains a controversial issue in clinical dentistry. This study aimed to evaluate whether the salivary alpha-amylase (sAA), cortisol levels, and anxiety symptoms differ between children with and without TMD. Initially, 316 young subjects were screened in public schools (nonreferred sample); 76 subjects aged 7-14 years were selected and comprised the TMD and control groups with 38 subjects each matched by sex, age, and the presence/absence of sleep bruxism. Four saliva samples were collected: upon waking, 30 min and 1 h after awakening (fasting), and at night (at 8 PM) on 2 alternate days to examine the diurnal profiles of cortisol and sAA. Anxiety symptoms were screened using the Multidimensional Anxiety Scale for Children (MASC-Brazilian version). Shapiro-Wilk test, Student's t-test/Mann-Whitney U test, and correlation tests were used for data analysis. No significant differences were observed in the salivary cortisol area under the curve (AUC G mean ± SD = 90.22 ± 63.36 × 94.21 ± 63.13 µg/dL/min) and sAA AUC G (mean ± SD = 2544.52 ± 2142.00 × 2054.03 ± 1046.89 U/mL/min) between the TMD and control groups, respectively (p > 0.05); however, the clinical groups differed in social anxiety domain (t = 3.759; CI = 2.609, 8.496), separation/panic (t = 2.243; CI = 0.309, 5.217), physical symptoms (U = 433.500), and MASC total score (t = −3.527; CI = −23.062, −6.412), with a power of the test >80% and large effect size (d = 0.80), with no significant correlation between the MASC total score, cortisol, and sAA levels. Although children with TMD scored higher in anxiety symptoms, no difference was observed in the salivary stress biomarkers between children with and without TMD.

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confidence: 99%

Salivary stress biomarkers and anxiety symptoms in children with and without temporomandibular disorders

et al. 2017

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“…Significant associations between compounds grouped by principal component analysis and obese asthma, current respiratory symptoms, obesity and body composition were also observed, even for low levels of EDCs exposure. Furthermore, our results showed that exposure to individual or combined EDCs is associated with changes in the ANS, specifically parasympathetic dysautonomia assessed through pupillometry, thus suggesting that EDCs may increase parasympathetic activity, resulting in a subsequent increase in the risk of asthma and obesity.…”

Section: Discussionmentioning

confidence: 68%

Exposure to indoor endocrine‐disrupting chemicals and childhood asthma and obesity

Paciência

Rufo

Silva

et al. 2019

Allergy

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Background: Indoor air contaminants may act as endocrine-disrupting chemicals (EDCs). However, to what extent these contaminants affect health is poorly known.We aimed to assess the association between EDCs exposure and asthma, respiratory symptoms and obesity in schoolchildren.Methods: Data from a cross-sectional analysis of 815 participants from 20 schools in Porto, Portugal, were analysed. Symptoms were assessed, asthma was defined on lung function, and airway reversibility and body mass index (BMI) were calculated.The concentrations of 13 volatile organic compounds and 2 aldehydes identified as EDCs were measured in 71 classrooms throughout 1 week. Principal component analysis (PCA) was used to assess the effect of co-exposure. Associations were estimated by regression coefficients using linear and logistic regression models.Results: Increased individual and combined EDCs levels were found in classrooms having more children with asthma and obesity. Higher levels of hexane, styrene, cyclohexanone, butylated hydroxytoluene and 2-butoxyethanol were associated with obesity, and higher levels of cyclohexanone were associated with increased child BMI. Toluene, oxylene, m/p-xylene and ethylbenzene were significantly associated with nasal obstruction.A positive association was found between PC1 and the risk of obese asthma (OR = 1.43, 95% CI 1.01, 1.98) and between PC2 and overweight (OR = 1.51, 95% CI 1.28, 1.79).PC1 and PC2 were also associated with nasal obstruction, and PC2 was associated with breathing difficulties and lean body mass, although EDCs concentrations were low. Conclusions:Our findings further support the role of EDCs in asthma and obesity development. Moreover, even low levels of indoor exposure may influence the risk of asthma, respiratory symptoms and obesity.

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“…In their study, Manfredini et al [25] have shown that pain-related disability is strongly associated with depression and somatization. Other neurobiological mechanisms such as interference with endogenous regulator of the pain system, genetic factors as well as the disruption of the adrenergic function of the autonomic nervous system have also been put forward as contributing factors in the pathogenesis of CMD (Monaco et al [26]; Rinchuse and Kandasamy [27]).…”

Section: Resultsmentioning

confidence: 99%

Craniomandibular Disorders and Mandibular Reference Position in Orthodontic Treatment

Bourzgui

Aghoutan

Diouny

2013

International Journal of Dentistry

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The aim of this paper is to bring into focus the literature on the choice of the mandibular reference position in orthodontic treatment; of a particular reference to this paper is intercuspal position, centric relation position, or therapeutic position. To give a comprehensive account of the literature review on craniomandibular disorders (CMD), we have relied on books and articles using both Google Scholar and PubMed. Selection criteria included a combination of Mesh and type of article. Article classification was made by two authors, using the following structure outline: prevalence of craniomandibular disorders, its etiology and pathophysiology, occlusion and craniomandibular disorders, orthodontic treatment and CMD, and the mandibular reference position in orthodontics. An important conclusion that emerged from the present literature review is that CMD do not seem to be directly related to orthodontic treatment, and their appearance cannot be predicted or prevented by any means. Therefore, orthodontists must adopt a mandibular reference suitable to their patients and which best respects the balance existing in the stomatognathic system.

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Dysregulation of the Autonomous Nervous System in Patients with Temporomandibular Disorder: A Pupillometric Study

Cited by 32 publications

References 43 publications

Salivary stress biomarkers and anxiety symptoms in children with and without temporomandibular disorders

Salivary stress biomarkers and anxiety symptoms in children with and without temporomandibular disorders

Exposure to indoor endocrine‐disrupting chemicals and childhood asthma and obesity

Craniomandibular Disorders and Mandibular Reference Position in Orthodontic Treatment

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