Dysregulation of the microbiota-brain axis during long-term exposure to polystyrene nanoplastics in rats and the protective role of dihydrocaffeic acid

Jiang, Wenbo; Hu, Cong; Chen, Yunyan; Li, Yue; Sun, Xinyi; Wu, Huanyu; Yang, Ruiming; Tang, Yi‐Wei; Niu, Fengru; Wei, Wei; Sun, Chengbo; Han, Tianshu

doi:10.1016/j.scitotenv.2023.162101

Cited by 20 publications

(2 citation statements)

References 44 publications

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“…Additionally, LEfSe analysis showed that the characteristic bacterial species found in acephate-exposed mice were Proteobacteria, Bacteroidetes, and Deferribacteres. Exposure to polystyrene nano-plastics induces anxiety-like behavior in rats by upregulating the abundance of these species ( Jiang et al, 2023 ). High-fat diet feeding increases the Proteobacteria population and leads to memory impairment and anxiety-like behaviors in mice ( Jeong et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Male mice are susceptible to brain dysfunction induced by early-life acephate exposure

Sasaki,

Islam,

Hara

et al. 2024

Front. Neurosci.

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BackgroundAcephate is a widely used organophosphate insecticide. Exposure to endocrine-disrupting chemicals, such as acephate, can interfere with neurodevelopment in childhood, increasing the risk of higher brain dysfunction later in life. Furthermore, brain dysfunction may be related to chemical exposure-related disturbances in the gut microbiota. However, the effects of early acephate exposure on the brains of adult males and females as well as on the adult gut environment remain poorly understood.MethodsThis study investigated the effects of perinatal acephate exposure on the central nervous system and gut microbiota of mice, including sex differences and environmentally relevant concentrations. C57BL/6 N pups were exposed to acephate (0, 0.3, 10, and 300 ppm) via the dam in their drinking water from embryonic day (E) 11.5 to postnatal day 14. We examined its effects on the central nervous system of adult males and females.ResultsIn the male treatment group, impairments in learning and memory were detected. Immunohistochemical analysis revealed a decrease in SOX2-, NeuN-, DCX-, and GFAP-positive cells in the hippocampal dentate gyrus in males compared to the control group, whereas GFAP-positive cells were fewer in females. In addition, gut microbiota diversity was reduced in both sexes in the experimental group.ConclusionOur study demonstrates that the effects of early-life exposure to acephate are more pronounced in males than in females and can lead to a lasting impact on adult behavior, even at low doses, and that the gut microbiota may reflect the brain environment.

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Section: Discussionmentioning

confidence: 99%

Male mice are susceptible to brain dysfunction induced by early-life acephate exposure

Sasaki,

Islam,

Hara

et al. 2024

Front. Neurosci.

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“…Numerous papers have shown gut exposure to a single-type of MP results in the accumulation of particles in the liver likely due to the gut-liver axis (Shi et al 2022;Wang et al 2022). Given these studies also examined a single plastic (Chen et al 2022;Cheng et al 2022;Jiang et al 2023;Shi et al 2022;Tu et al 2023;Wang et al 2022), we were particularly interested in metabolomics changes from mice exposed to the single PS plastics compared to the mixed plastic exposure. Therefore, untargeted metabolomics was performed on liver tissues from all microplastic exposed animals compared to non-exposed mice.…”

Section: Oral Gastric Exposure Of Mp Alters the Liver Metabolomementioning

confidence: 99%

In Vivo Tissue Distribution of Microplastics and Systemic Metabolomic Alterations After Gastrointestinal Exposure

Garcia,

Romero,

Merkley

et al. 2023

Preprint

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Global plastic use has consistently increased over the past century with several different types of plastics now being produced. Much of these plastics end up in oceans or landfills leading to a substantial accumulation of plastics in the environment. Plastic debris slowly degrades into microplastics (MPs) that can ultimately be inhaled or ingested by both animals and humans. A growing body of evidence indicates that MPs can cross the gut barrier and enter into the lymphatic and systemic circulation leading to accumulation in tissues such as the lungs, liver, kidney, and brain. The impacts of mixed MPs exposure on tissue function through metabolism remains largely unexplored. To investigate the impact of ingested MPs on target metabolomic pathways, mice were subjected to either polystyrene microspheres or a mixed plastics (5 micron) exposure consisting of polystyrene, polyethylene and the biodegradability and biocompatible plastic, poly-(lactic-co-glycolic acid). Exposures were performed twice a week for four weeks at a dose of either 0, 2, or 4 mg/week via oral gastric gavage. Our findings demonstrate that, in mice, ingested MPs can pass through the gut barrier, be translocated through the systemic circulation, and accumulate in distant tissues including the brain, liver, and kidney. Additionally, we report on the metabolomic changes that occur in the colon, liver and brain which show differential responses that are dependent on dose and type of MPs exposure. Lastly, our study provides proof of concept for identifying metabolomic alterations associated with MPs exposure and adds insight into the potential health risks that mixed MPs contamination may pose to humans.

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Human Toxicity of Nano‐ and Microplastics

Cruz Salas,

Perez,

Bobadilla

et al. 2024

Toxic Effects of Micro‐ and Nanoplastics

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Dysregulation of the microbiota-brain axis during long-term exposure to polystyrene nanoplastics in rats and the protective role of dihydrocaffeic acid

Cited by 20 publications

References 44 publications

Male mice are susceptible to brain dysfunction induced by early-life acephate exposure

Male mice are susceptible to brain dysfunction induced by early-life acephate exposure

In Vivo Tissue Distribution of Microplastics and Systemic Metabolomic Alterations After Gastrointestinal Exposure

Human Toxicity of Nano‐ and Microplastics

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