Dysregulations of metabolites and gut microbes and their associations in rats with noise induced hearing loss

Li, Ningning; Zhang, Xiuzhi; Cui, Yanan; Wu, Hui; Yu, Yue; Yu, Shanfa

doi:10.3389/fmicb.2023.1229407

Cited by 4 publications

(1 citation statement)

References 44 publications

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“…In contrast, indolelactic acid, hippuric acid, 2,6-dihydroxybenzoic acid, 7-keto-3a, 12-a-dihydroxycholanic acid, acetaminophen sulfate, isatin, and quillaic acid were decreased in the noise-exposed group. Furthermore, seven pathways including glycosaminoglycan biosynthesis—keratan sulfate, N-glycan biosynthesis, the adipocytokine signalling pathway, peroxisome, bile secretion, various types of N-glycan biosynthesis, and the cAMP signalling pathway were shown to be dysregulated after noise exposure [ 65 ].…”

Section: Investigating Inner Ear Diseases Through Proteomics and Meta...mentioning

confidence: 99%

The Current State of Proteomics and Metabolomics for Inner Ear Health and Disease

Khorrami,

Pastras,

Haynes

et al. 2024

Proteomes

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Characterising inner ear disorders represents a significant challenge due to a lack of reliable experimental procedures and identified biomarkers. It is also difficult to access the complex microenvironments of the inner ear and investigate specific pathological indicators through conventional techniques. Omics technologies have the potential to play a vital role in revolutionising the diagnosis of ear disorders by providing a comprehensive understanding of biological systems at various molecular levels. These approaches reveal valuable information about biomolecular signatures within the cochlear tissue or fluids such as the perilymphatic and endolymphatic fluid. Proteomics identifies changes in protein abundance, while metabolomics explores metabolic products and pathways, aiding the characterisation and early diagnosis of diseases. Although there are different methods for identifying and quantifying biomolecules, mass spectrometry, as part of proteomics and metabolomics analysis, could be utilised as an effective instrument for understanding different inner ear disorders. This study aims to review the literature on the application of proteomic and metabolomic approaches by specifically focusing on Meniere’s disease, ototoxicity, noise-induced hearing loss, and vestibular schwannoma. Determining potential protein and metabolite biomarkers may be helpful for the diagnosis and treatment of inner ear problems.

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Section: Investigating Inner Ear Diseases Through Proteomics and Meta...mentioning

confidence: 99%

The Current State of Proteomics and Metabolomics for Inner Ear Health and Disease

Khorrami,

Pastras,

Haynes

et al. 2024

Proteomes

View full text Add to dashboard Cite

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Noise - an insidious stressor affecting xenobiotic metabolism?

Waring,

Mitchell

2024

Xenobiotica

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Characteristic alterations of gut microbiota and serum metabolites in patients with chronic tinnitus: a multi-omics analysis

Wang,

Xiang,

Peng

et al. 2024

Microbiol Spectr

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Chronic tinnitus is a central nervous system disorder. Currently, the effects of gut microbiota on tinnitus remain unexplored. To explore the connection between gut microbiota and tinnitus, we conducted 16S rRNA sequencing of fecal microbiota and serum metabolomic analysis in a cohort of 70 patients with tinnitus and 30 healthy volunteers. We used the weighted gene co-expression network method to analyze the relationship between the gut microbiota and the serum metabolites. The random forest technique was utilized to select metabolites and gut taxa to construct predictive models. A pronounced gut dysbiosis in the tinnitus group, characterized by reduced bacterial diversity, an increased Firmicutes/Bacteroidetes ratio, and some opportunistic bacteria including Aeromonas and Acinetobacter were enriched. In contrast, some beneficial gut probiotics decreased, including Lactobacillales and Lactobacillaceae. In serum metabolomic analysis, serum metabolic disturbances in tinnitus patients and these differential metabolites were enriched in pathways of neuroinflammation, neurotransmitter activity, and synaptic function. The predictive models exhibited great diagnostic performance, achieving 0.94 (95% CI: 0.85–0.98) and 0.96 (95% CI: 0.86–0.99) in the test set. Our study suggests that changes in gut microbiota could potentially influence the occurrence and chronicity of tinnitus, and exert regulatory effects through changes in serum metabolites. Overall, this research provides new perceptions into the potential role of gut microbiota and serum metabolite in the pathogenesis of tinnitus, and proposes the “gut-brain-ear” concept as a pathomechanism underlying tinnitus, with significant clinical diagnostic implications and therapeutic potential. IMPORTANCE Tinnitus affects millions of people worldwide. Severe cases may lead to sleep disorders, anxiety, and depression, subsequently impacting patients’ lives and increasing societal healthcare expenditures. However, tinnitus mechanisms are poorly understood, and effective therapeutic interventions are currently lacking. We discovered the gut microbiota and serum metabolomics changes in patients with tinnitus, and provided the potential pathological mechanisms of dysregulated gut flora in chronic tinnitus. We proposed the innovative concept of the “gut-brain-ear axis,” which underscores the exploration of gut microbiota impact on susceptibility to chronic tinnitus through serum metabolic profile modulation. We also reveal novel biomarkers associated with chronic tinnitus, offering a new conceptual framework for further investigations into the susceptibility of patients, potential treatment targets for tinnitus, and assessing patient prognosis. Subsequently, gut microbiota and serum metabolites can be used as molecular markers to assess the susceptibility and prognosis of tinnitus.Furthermore, fecal transplantation may be used to treat tinnitus.

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Dysregulations of metabolites and gut microbes and their associations in rats with noise induced hearing loss

Cited by 4 publications

References 44 publications

The Current State of Proteomics and Metabolomics for Inner Ear Health and Disease

The Current State of Proteomics and Metabolomics for Inner Ear Health and Disease

Noise - an insidious stressor affecting xenobiotic metabolism?

Characteristic alterations of gut microbiota and serum metabolites in patients with chronic tinnitus: a multi-omics analysis

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