Dystrophin deficiency impairs cell junction formation during embryonic myogenesis from pluripotent stem cells

Mozin, Elise; Massouridès, Emmanuelle; Mournetas, Virginie; Lièvre, Clémence; Bourdon, Audrey; Jackson, Dana L.; Packer, Jonathan S.; Seong, Juyoung; Trapnell, Cole; Le Guiner, Caroline; Adjali, Oumeya; Pinset, Christian; Mack, David L.; Dupont, Jean-Baptiste

doi:10.1016/j.isci.2024.110242

iScience

2024

DOI: 10.1016/j.isci.2024.110242

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Dystrophin deficiency impairs cell junction formation during embryonic myogenesis from pluripotent stem cells

Elise Mozin,

Emmanuelle Massouridès,

Virginie Mournetas

et al.

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Uncovering the Embryonic Origins of Duchenne Muscular Dystrophy

Barrett,

Louie,

Dupont

et al. 2024

WIREs Mechanisms of Disease

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Duchenne muscular dystrophy (DMD) is a severe degenerative muscle disease caused by mutations in the DMD gene, which encodes dystrophin. Despite its initial description in the late 19th century by French neurologist Guillaume Duchenne de Boulogne, and identification of causal DMD genetic mutations in the 1980s, therapeutics remain challenging. The current standard of care is corticosteroid treatment, which delays the progression of muscle dysfunction but is associated with significant adverse effects. Emerging therapeutic approaches, including AAV‐mediated gene transfer, CRISPR gene editing, and small molecule interventions, are under development but face considerable obstacles. Although DMD is viewed as a progressive muscle disease, muscle damage and abnormal molecular signatures are already evident during fetal myogenesis. This early onset of pathology suggests that the limited success of current therapies may partly be due to their administration after aberrant embryonic myogenesis has occurred in the absence of dystrophin. Consequently, identifying optimal therapeutic strategies and intervention windows for DMD may depend on a better understanding of the earliest DMD disease mechanisms. As newer techniques are applied, the field is gaining increasingly detailed insights into the early muscle developmental abnormalities in DMD. A comprehensive understanding of the initial events in DMD pathogenesis and progression will facilitate the generation and testing of effective therapeutic interventions.

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Uncovering the Embryonic Origins of Duchenne Muscular Dystrophy

Barrett,

Louie,

Dupont

et al. 2024

WIREs Mechanisms of Disease

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show abstract

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Dystrophin deficiency impairs cell junction formation during embryonic myogenesis from pluripotent stem cells

Cited by 1 publication

References 70 publications

Uncovering the Embryonic Origins of Duchenne Muscular Dystrophy

Uncovering the Embryonic Origins of Duchenne Muscular Dystrophy

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