2019
DOI: 10.3390/ijms20112632
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(E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) Phenol Ameliorates MPTP-Induced Dopaminergic Neurodegeneration by Inhibiting the STAT3 Pathway

Abstract: Neuroinflammation is implicated in dopaminergic neurodegeneration. We have previously demonstrated that (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol (MMPP), a selective signal transducer and activator of transcription 3 (STAT3) inhibitor, has anti-inflammatory properties in several inflammatory disease models. We investigated whether MMPP could protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic cell loss and behavioral impairment. Imprinting control region (… Show more

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Cited by 5 publications
(2 citation statements)
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“…This signal pathway can also be triggered by exposure to manganese in microglia, leading to neuronal loss (Yin et al, 2018). However, microRNA-93 (Wang et al, 2021) and (E)-2methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol (Choi et al, 2019) can engender the downregulation of STAT3 to abrogate the MPTP-induced dopaminergic neurodegeneration. Similarly, nitidine has been shown to inhibit the phosphorylation of JAK2/STAT3 and block STAT3 nuclear translocation, exerting neuroprotective effects in PD models (Wang et al, 2016).…”
Section: Introductionmentioning
confidence: 99%
“…This signal pathway can also be triggered by exposure to manganese in microglia, leading to neuronal loss (Yin et al, 2018). However, microRNA-93 (Wang et al, 2021) and (E)-2methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol (Choi et al, 2019) can engender the downregulation of STAT3 to abrogate the MPTP-induced dopaminergic neurodegeneration. Similarly, nitidine has been shown to inhibit the phosphorylation of JAK2/STAT3 and block STAT3 nuclear translocation, exerting neuroprotective effects in PD models (Wang et al, 2016).…”
Section: Introductionmentioning
confidence: 99%
“…Recently, anti-inflammatory effects of (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol, a STAT3 inhibitor, was demonstrated. Oral intake of (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol for 1 month showed strong neuroprotective effects in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice model of PD [4]. The control of inflammation is a hopeful therapeutic target for PD.…”
mentioning
confidence: 99%