E-cadherin and β-catenin expression in well-differentiated and moderately-differentiated oral squamous cell carcinoma: relations with clinical variables

Rosado, Pablo; Lequerica-Fernández, Paloma; Fernández, Susana; Allonca, Eva; Villallaín, Lucas; Vicente, Juan Carlos de

doi:10.1016/j.bjoms.2012.03.018

Cited by 33 publications

(43 citation statements)

References 21 publications

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“…A recent study by Rosado et al (2013) studied E-cadherin expression in normal oral mucosa and in oral squamous cell carcinomas immunohistochemically. E-cadherin was significantly associated with histological grade.…”

Section: Figure 3 A) the Staining Of Normal Epithelial Tissue For E-mentioning

confidence: 99%

Relationships Between Clinical Behavior of Laryngeal Squamous Cell Carcinomas and Expression of VEGF, MMP-9 and E-Cadherin

Akdeniz

Akduman²,

Haksever³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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The biological mechanisms of cancer and associations with behavior of tumours need to be studied to understand progression and determine appropriate treatments. Here we investigated expression of VEGF, MMP-9 and E-cadherin in laryngeal SCCs and their relations with clinical behavior. This prospective study was based on 38 surgical specimens from patients with primary laryngeal SCC and data recorded in their cards. Expression of the three factors in tumor tissue was examined using immunohistochemistry and correlations with clinical parameters of primary tumors, regional lymph node metastases, stage of disease, histopathologic differentiation, and vascular/cartilage invasion were investigated. Regarding the cases with positive MMP-9 expression, the difference between well and moderately/poorly differentiated tumors was statistically significant. However, differences between early stage (stage I and II) and late-stage (stage III and IV) tumours, and between positive and negative for pLN metastasis were not. No significant relationship between positive VEGF and tumor differentiation or stage was apparent, but E-cadherin levels significantly differed between well and moderately/ poorly differentiated tumours and with the presence of pLN metastasis. E-cadherin staining did not vary between MMP-9 positive and negative cases. In conclusion, MMP-9 may be a negative predictor of differentiation in laryngeal SCC, while E-cadherin is a predictor of differentiation and nodal metastases. Even if the difference between VEGF expression and tumor stage was not statistically significant, it seems that there exists some relationship, which might be clarified with a greater number of cases.

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Section: Figure 3 A) the Staining Of Normal Epithelial Tissue For E-mentioning

confidence: 99%

Relationships Between Clinical Behavior of Laryngeal Squamous Cell Carcinomas and Expression of VEGF, MMP-9 and E-Cadherin

Akdeniz

Akduman²,

Haksever³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…6,13 The resultant loss of cell adhesion and the acquisition of cellular motility is an essential event in tumor cell invasion and distant spread. 9 The acantholytic dysplastic cells in AD presented here show a loss of E-cadherin expression and increased cytoplasmic expression of b-catenin. These features recapitulate those seen in the cases of ASCC.…”

Section: Discussionmentioning

confidence: 69%

“…8 Several oral ASCCs have been identified at other sites, including the buccal mucosa, floor of mouth, and tongue. 9,10 These lesions are reported to have a poorer prognosis than conventional SCC at the same site. 5,9,11 Most of our accumulated knowledge in this regard is based on a handful of case reports with little follow-up information with which to reach definitive conclusions regarding the biologic behavior.…”

Section: Discussionmentioning

confidence: 99%

“…9,10 These lesions are reported to have a poorer prognosis than conventional SCC at the same site. 5,9,11 Most of our accumulated knowledge in this regard is based on a handful of case reports with little follow-up information with which to reach definitive conclusions regarding the biologic behavior. Although the lesions in this patient shared overlapping histomorphology with those of ASCC, the presence of adenoid structures containing acantholytic epithelial cells within epithelial dysplasia or even in verrucous carcinoma has not been previously reported and was distinct enough to warrant documentation.…”

Section: Discussionmentioning

confidence: 99%

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Adenoid dysplasia of the oral mucosa

Bunn

Hunter

Khurram

et al. 2014

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Objective. To describe an unusual variant of oral epithelial dysplasia and to provide an appraisal of its immunohistochemical profile. Study Design. An unusual form of epithelial dysplasia, which we have termed adenoid dysplasia, was evaluated for staining of cytokeratins AE1/AE3, vimentin, E-cadherin, and b-catenin. The immunohistochemical results were compared with those observed in moderate epithelial dysplasia, moderately differentiated squamous cell carcinoma, and acantholytic squamous cell carcinoma.Results. The immunoprofile of adenoid dysplasia was similar to that of acantholytic squamous cell carcinoma. Cytokeratin positivity within the acantholytic dysplastic cells confirmed their epithelial nature, and upregulation of vimentin was suggestive of epithelial-mesenchymal transition. The most distinctive finding was a loss of E-cadherin expression within the discohesive cells, accompanied by increased cytosolic expression of b-catenin.Conclusions. This report presents the histomorphologic features of a unique form of oral epithelial dysplasia, termed adenoid dysplasia.

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“…Um exemplo disso é representado pela ativação da via de sinalização de Wnt causando alteração no padrão de expressão de β-catenina, o que tem sido frequentemente identificado em diversos tumores malignos (TANAKA et al, 2003;MAHOMED;ALTINI;MEER, 2007;ROSADO et al, 2013;SOARES et al, 2015). No entanto, implicação desta via Wnt nos carcinomas espinocelulares bucais ainda é considerada pouco explorada (SANTORO et al, 2014).…”

Section: Figura 7 -unclassified

Avaliação da expressão de β-catenina e ciclina D1 como biomarcadores preditivos para o câncer de lábio

Garcia¹

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E-cadherin and β-catenin expression in well-differentiated and moderately-differentiated oral squamous cell carcinoma: relations with clinical variables

Cited by 33 publications

References 21 publications

Relationships Between Clinical Behavior of Laryngeal Squamous Cell Carcinomas and Expression of VEGF, MMP-9 and E-Cadherin

Relationships Between Clinical Behavior of Laryngeal Squamous Cell Carcinomas and Expression of VEGF, MMP-9 and E-Cadherin

Adenoid dysplasia of the oral mucosa

Avaliação da expressão de β-catenina e ciclina D1 como biomarcadores preditivos para o câncer de lábio

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E-cadherin and β-catenin expression in well-differentiated and moderately-differentiated oral squamous cell carcinoma: relations with clinical variables

Cited by 33 publications

References 21 publications

Relationships Between Clinical Behavior of Laryngeal Squamous Cell Carcinomas and Expression of VEGF, MMP-9 and E-Cadherin

Relationships Between Clinical Behavior of Laryngeal Squamous Cell Carcinomas and Expression of VEGF, MMP-9 and E-Cadherin

Adenoid dysplasia of the oral mucosa

Avaliação da expressão de &#x3B2;-catenina e ciclina D1 como biomarcadores preditivos para o câncer de lábio

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Avaliação da expressão de β-catenina e ciclina D1 como biomarcadores preditivos para o câncer de lábio