E-Cadherin/β-Catenin Complex: A Target for Anticancer and Antimetastasis Plants/Plant-derived Compounds

Abstract

Plants reputed to have cancer-inhibiting potential and putative active components derived from those plants have emerged as an exciting new field in cancer study. Some of these compounds have cancer-inhibiting potential in different clinical staging levels, especially metastasis. A few of them which stabilize cell-cell adhesions are controversial topics. This review article introduces some effective herbal compounds that target E-cadherin/β-catenin protein complex. In this article, at first, we briefly review the structure and function of E-cadherin and β-catenin proteins, Wnt signaling pathway, and its target genes. Then, effective compounds of the Teucrium persicum, Teucrium polium, Allium sativum (garlic), Glycine max (soy), and Brassica oleracea (broccoli) plants, which influence stability and cellular localization of E-cadherin/β-catenin complex, were studied. Based on literature review, there are some compounds in these plants, including genistein of soy, sulforaphane of broccoli, organosulfur compounds of garlic, and the total extract of Teucrium genus that change the expression of variety of Wnt target genes such as MMPs, E-cadherin, p21, p53, c-myc, and cyclin D1. So they may induce cell-cycle arrest, apoptosis and/or inhibition of Epithelial-Mesenchymal Transition (EMT) and metastasis.

FadA promotes DNA damage and progression of Fusobacterium nucleatum-induced colorectal cancer through up-regulation of chk2

“…The activation, as well as the inhibition, of the Ecadherin/β-catenin pathway has been shown to be involved in multiple cancers including renal and liver cancers [39][40][41]. The E-cadherin/β-catenin pathway, therefore, has been proposed to be a potential target for cancer therapy because of its role in regulating genes or mediators involved in cancer development and progression [42][43][44]. In a related finding, Zhao et al demonstrated the involvement of the E-cadherin/β-catenin pathway activation in CRC development [45].…”

Long non‐coding RNA myocardial infarction associated transcript promotes epithelial‐mesenchymal transition and is an independent risk factor for poor prognosis of tongue squamous cell carcinoma

“…Decreased expression of E‐cadherin together with increased expression of mesenchymal cadherins such as N‐cadherin is the most significant characteristics of EMT. Besides, another adhesion factor, β‐catenin, also plays an important role in the EMT process of many cancers …”

“…Besides, another adhesion factor, β-catenin, also plays an important role in the EMT process of many cancers. 6 With the rapid development of genome sequencing technologies, it was found that more than 90% of DNA sequences are actively transcribed but only <2% were subsequently translated to encode proteins, and these rest transcripts were called non-coding RNAs (ncRNAs). 7 Long non-coding RNAs (lncRNAs) refer to a group of ncRNAs containing more than 200 nucleotides.…”

Anti-Carcinogenic Glucosinolates in Cruciferous Vegetables and Their Antagonistic Effects on Prevention of Cancers

“…Dietary intake of fruits and vegetables becomes a common practice to avoid the cause of cancers [ 4 ]. Plants and its natural products have potential to inhibit cancer [ 5 ], reduces the risk of cancer. Several studies previously reported that uptake of Cruciferous vegetables on a daily basis helps to avoid the occurrence of cancer.…”