e-Health in Cardiovascular Medicine

Redfern, Julie; Neubeck, Lis

doi:10.3390/medsci7060072

Cited by 2 publications

(4 citation statements)

References 13 publications

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“…Cardiovascular disease (CVD) is a major cause of mortality worldwide, accounting for around 17.9 million deaths each year [ 1 ]. Excess consumption of saturated fatty acids, sugar-sweetened beverages, and alcohol is among the dietary and lifestyle behaviors associated with CVD development [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

“…Acarbose attenuates migration/proliferation via targeting microRNA-143 in vascular smooth muscle cells under diabetic conditions 1. Introduction C ardiovascular disease (CVD) is a major cause of mortality worldwide, accounting for around 17.9 million deaths each year [1]. Excess consumption of saturated fatty acids, sugar-sweetened beverages, and alcohol is among the dietary and lifestyle behaviors associated with CVD development [2].…”

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Acarbose attenuates migration/proliferation via targeting microRNA-143 in vascular smooth muscle cells under diabetic conditions

Chuang¹,

Yu²,

Yang³

et al. 2020

Journal of Food and Drug Analysis

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Acarbose (an a-glucosidase inhibitor) has been demonstrated to reduce the progression of atherosclerosis without affecting serum levels of glucose in rabbits fed a high cholesterol diet. The main focus of recent atherosclerosis studies has been microRNA targets. However, the mechanism by which acarbose targets miRNA-mediated atherosclerosis remains unclear. This study aimed to evaluate the effect of acarbose on microRNA-related regulation of rat aortic vascular smooth cell line (A7r5 cell) migration and proliferation induced by diabetic conditions. We reported that acabose exhibit significantly inhibits proliferative and cell migration abilities in A7r5 cells. The expression of protein and levels of mRNA were measured by Western blot analysis and real-time PCR. Acarbose inhibited the phosphorylation of focal adhesion kinase (FAK) and phosphoinositide 3-kinases (PI3K)/protein kinase B (Akt), Ras signals, small GTPase proteins expression to attenuate cell migration and proliferation. Furthermore, acarbose upregulated the expression of miR-143, and transfected miR-143 mimic and its inhibitor to explore its mechanism. In conclusion, acarbose reduces VSMC migration and proliferation via upregulating miR-143 to inhibit Ras-related signaling, and potentially prevention of atherosclerosis.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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Acarbose attenuates migration/proliferation via targeting microRNA-143 in vascular smooth muscle cells under diabetic conditions

Chuang¹,

Yu²,

Yang³

et al. 2020

Journal of Food and Drug Analysis

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“…Cardiovascular disease (CVD) is considered as the number one global cause of mortality with around 18 million persons dying each year from it. 245 CVD risk factors are multifocal and high lipid profiles, lead to atherosclerosis and other vascular defects which arise commonly in most populations that consume high fat (lipid peroxidation, dyslipidemia) and/or high sugar diet. 246 These defects arise from mitochondrial glucose oxidation resulting in mitochondrial ROS, which causes oxidative stress damage to the vasculature.…”

Section: Cardiovascular Diseasementioning

confidence: 99%

Revisiting the therapeutic potential of tocotrienol

2022

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The therapeutic potential of the tocotrienol group stems from its nutraceutical properties as a dietary supplement. It is largely considered to be safe when consumed at low doses for attenuating pathophysiology as shown by animal models, in vitro assays, and ongoing human trials. Medical researchers and the allied sciences have experimented with tocotrienols for many decades, but its therapeutic potential was limited to adjuvant or concurrent treatment regimens. Recent studies have focused on targeted drug delivery by enhancing the bioavailability through carriers, self‐sustained emulsions, nanoparticles, and ethosomes. Epigenetic modulation and computer remodeling are other means that will help increase chemosensitivity. This review will focus on the systemic intracellular anti‐cancer, antioxidant, and anti‐inflammatory mechanisms that are stimulated and/or regulated by tocotrienols while highlighting its potent therapeutic properties in a diverse group of clinical diseases.

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e-Health in Cardiovascular Medicine

Abstract: Cardiovascular disease (CVD), including coronary artery disease (CHD) and stroke, is the leading cause of death and disease burden globally [...]

Cited by 2 publications

References 13 publications

Acarbose attenuates migration/proliferation via targeting microRNA-143 in vascular smooth muscle cells under diabetic conditions

Acarbose attenuates migration/proliferation via targeting microRNA-143 in vascular smooth muscle cells under diabetic conditions

Revisiting the therapeutic potential of tocotrienol

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