Effects on Senile Skin Atrophy Due to Administration of Parotin (Hormone of Salivary Glands)

Abstract

Skin atrophy is one of the senile changes of the human body. In the histological pictures of the atrophied skin, we notice a thinning of the epithelial layer, a disappearing of papillae, a flattening of the basal layer, a diminishing of capillaries, especially in papillae, a degeneration and disappearance of elastic fibers in papillae and cutis, etc.Both Ogata and Takixawa, in considering the relationship between senile changes and asialadenism, acknowledge in their experimental studies on salivary glands, an important role of decreasing endocrine function of the salivary glands, resulting in the appearance of senile skin atrophy.It may be of some interest to know the effects of Parotin, i.e. the hormone of the salivary glands, on this senile skin atrophy.In an experiment on a human body which was made possible through the willingness of an aged gentleman, we had the opportunity of observing the effects of the Parotin supplement to the atrophied skin.