2024
DOI: 10.21203/rs.3.rs-3845460/v1
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E2F-1 inhibits ferroptosis in osteosarcoma cells by activating the PSAT1/Xct/GPX4 signaling axis

Po Wang,
Jun Xiao,
Jin Zeng
et al.

Abstract: Osteosarcoma is a common primary malignant bone tumour that occurs mainly in children and adolescents and has a poor survival and prognosis. Currently, ferroptosis is a newly defined form of cell death, but the mechanism between it and osteosarcoma is unclear. To further investigate the relationship between osteosarcoma and ferroptosis, it is important to search for new biomolecular factors. We used bioinformatics to dig deeper into the ferroptosis gene PSAT1, which is closely associated with osteosarcoma. Alt… Show more

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