E2F1: Transcriptional Machinery in Colon Cancer

Vasavi, I.; Prathyusha, A. M. V. N.; Malothu, Ramesh; Kumar, Kalaivani; Naidu, B. Pratap; Bramhachari, Pallaval Veera; Yugandhar, N.M.; Ganesh, Pattabhiraman

doi:10.1007/978-981-10-6728-0_20

Role of Transcription Factors in Gastrointestinal Malignancies 2017

DOI: 10.1007/978-981-10-6728-0_20

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E2F1: Transcriptional Machinery in Colon Cancer

I. Vasavi

A. M. V. N. Prathyusha

Ramesh Malothu

et al.

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2020

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The E2F family as potential biomarkers and therapeutic targets in colon cancer

Yao

Shao

2020

PeerJ

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Background The E2F family is a group of genes encoding a series of transcription factors in higher eukaryotes and participating in the regulation of cell cycle and DNA synthesis in mammals. This study was designed to investigate the role of E2F family in colon cancer. Methods In this study, the transcriptional levels of E2F1-8 in patients with colon cancer from GEPIA was examined. Meanwhile, the immunohistochemical data of the eight genes were also obtained in the The Human Protein Atlas website. Additionally, we re-identified the mRNA expression levels of these genes via real time PCR. Furthermore, the association between the levels of E2F family and stage plot as wells overall survival of patients with colon cancer were analyzed. Results We found that the mRNA and protein levels of E2F1, E2F2, E3F3, E2F5, E2F7 and E2F8 were significantly higher in colon cancer tissues than in normal colon tissues while the expression levels of E2F4 and E2F6 displayed no significant difference between colon cancer tissues and normal tissues. Additionally, E2F3, E2F4, E2F7 and E2F8 were significantly associated with the stages of colon cancer. The Kaplan-Meier Plotter showed that the high levels of E2F3 conferred a worse overall survival and disease free survival of patients with colon cancer. Also, high levels of E2F4 resulted in a worse overall survival. Conclusion Our study implied that E2F3, E2F4, E2F7 and E2F8 are potential targets of precision therapy for patients with colon cancer while E2F1, E2F2, E3F3, E2F5, E2F7 and E2F8 are potential biomarkers for the diagnosis of colon cancer.

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The E2F family as potential biomarkers and therapeutic targets in colon cancer

Yao

Shao

2020

PeerJ

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E2F1: Transcriptional Machinery in Colon Cancer

Cited by 1 publication

References 18 publications

The E2F family as potential biomarkers and therapeutic targets in colon cancer

The E2F family as potential biomarkers and therapeutic targets in colon cancer

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