E3710, Long-Acting PPI as New Approach for the Treatment of Unmet Medical Needs for GERD

Kodama, Kotaro; Fujisaki, Hideaki; Tonomura, Hideo; Jindo, Miwa; Watanabe, Misako; Nagakawa, Junichi; Takeguchi, Noriaki

doi:10.5772/29085

Gastroesophageal Reflux Disease 2012

DOI: 10.5772/29085

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E3710, Long-Acting PPI as New Approach for the Treatment of Unmet Medical Needs for GERD

Kotaro Kodama¹,

Hideaki Fujisaki²,

Hideo Tonomura³

et al.

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2016

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Proton-Potassium (H+/K+) ATPases: Properties and Roles in Health and Diseases

Sakai

Fujii

Takeguchi³

2016

The Alkali Metal Ions: Their Role for Life

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As a physiological phenomenon, acid secretion from the stomach was known already at least in the 17th century. But its mechanism was elucidated in more recent times only. At the end of the 20th century, gastric H(+)/K(+)-ATPase in the parietal cells was found to be responsible for a final step of H(+) secretion in these cells. In this century, several Cl(-)-transporting proteins for gastric acid (hydrochloric acid; HCl) secretion have been found. As inhibitors of gastric acid secretion, histamine H2 receptor antagonists (H2 blockers) were developed in the 1970's. This discovery brought a great benefit; that is, peptic ulcers became treatable by administration of a drug. In 1980's, proton pump inhibitors (PPIs) were developed. The target of PPIs is gastric H(+)/K(+)-ATPase and the PPIs exert generally more potent effects compared with H2 blockers. Most recently, several K(+)-competitive inhibitors of the ATPase are being developed. Here, we introduce gastric H(+)/K(+)-ATPase and its related proteins for gastric acid secretion, and several gastric diseases and their treatment by medicines.

show abstract

Proton-Potassium (H+/K+) ATPases: Properties and Roles in Health and Diseases

Sakai

Fujii

Takeguchi³

2016

The Alkali Metal Ions: Their Role for Life

View full text Add to dashboard Cite

show abstract

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E3710, Long-Acting PPI as New Approach for the Treatment of Unmet Medical Needs for GERD

Cited by 1 publication

References 34 publications

Proton-Potassium (H+/K+) ATPases: Properties and Roles in Health and Diseases

Proton-Potassium (H+/K+) ATPases: Properties and Roles in Health and Diseases

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