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Sultanaliev, Tokan; Zhexembayev, Assan; Mukazhanov, Adilbek; Zharkymbekov, Bakhyt; Kuttymuratov, Gani; Spatayev, Zhanat; Ibrayev, Bauyrzhan; Yesmembetov, Kakharman; Ashimkhanova, Aiymkul; Asykbayev, Mels

doi:10.6002/ect.tdtd2015.p66

Cited by 3 publications

(2 citation statements)

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“…18 Another study from the National Oncology Center in Nur-Sultan reported 30 patients with liver cirrhosis due to HBV and HBV+HDV infections, and four cases of HCV infection among 64 transplantations carried out at the center. 19,20 These reports with high rates of viral hepatitis among transplant referrals indicate the need to identify the true prevalence of viral hepatitis to implement policies for reducing the burden of disease.…”

Section: Introductionmentioning

confidence: 99%

Epidemiological Characteristics of Chronic Viral Hepatitis in Kazakhstan: Data from Unified Nationwide Electronic Healthcare System 2014–2019

Ashimkhanova¹,

Syssoyev²,

Gusmanov³

et al. 2022

IDR

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Background: Viral hepatitis is the leading cause of hepatic cirrhosis and liver-related mortality, yet there are no countrywide epidemiological studies available to date in Kazakhstan. The aim of the study was to perform an estimation of mortality, prevalence and incidence of Hepatitis B and C infections and liver-related complications. Methods: Using centralized healthcare data from the Unified National Electronic Health System (UNEHS) for the period 2014-2019, a total of 82,700 registered patients with chronic viral hepatitis B (HBV), C (HCV) and D (HDV) have been extracted based on ICD −10 codes. Crude rates of incidence, prevalence and mortality, as well as age-, sex-and year-specific rates of incidence and mortality per 100,000 population were estimated. Unadjusted and adjusted hazard ratios were estimated using Cox proportional hazards regression modeling. Results: For the total number of 82,700 patients, 56.6% were represented by chronic HCV infection and 43.4% by HBV infection. The prevalence of coinfection was 10% for HBV+HDV and 3.5% for HBV+HCV. Both HBV and HCV were more prevalent among female patients (56%) and among Kazakh ethnic group (64.8%). Males with HBV had a higher probability of death than females; this trend was stronger among male patients with HCV. Russian ethnic groups infected with HBV had a higher risk of death compared to Kazakh and other ethnic groups. Whereas in HCV-infected patients, Russian ethnic group and other ethnic group had similar risk for death, but higher compared to Kazakhs. Conclusion: During the 2014-2019 period, prevalence, incidence and mortality from chronic HBV and HCV infections increased. Despite the disproportionately higher infection rate among females with chronic viral hepatitis, all-cause mortality was more than twofold higher among males. Higher death rates in Russian ethnic group compared to other ethnicities need to be evaluated in further studies for other confounding factors and associated comorbidities in this group.

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Section: Introductionmentioning

confidence: 99%

Epidemiological Characteristics of Chronic Viral Hepatitis in Kazakhstan: Data from Unified Nationwide Electronic Healthcare System 2014–2019

Ashimkhanova¹,

Syssoyev²,

Gusmanov³

et al. 2022

IDR

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“…Living donation is the most attractive option in solving the organ shortage problem [ 7 ]. In Kazakhstan, the first successful liver transplantation from a living donor was performed in 2011 in collaboration with a transplant team from Belarus [ 8 ]. Since 2013, liver transplantation numbers have been steadily increasing in transplant centers of Kazakhstan ( Figure 1 ).…”

Section: Introductionmentioning

confidence: 99%

Liver Transplantation: A 10-Year Low-Volume Transplant Center Experience in Kazakhstan

et al. 2021

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Background Liver transplantation is considered to be the best available treatment option for patients with liver failure. In Kazakhstan, the liver transplantation program was established a decade ago. In this study, we analyzed a low-volume transplant center experience of liver transplantation in Kazakhstan. Material/Methods Clinical data of the 64 consecutive liver transplantations from deceased and living donors between 2010 and 2020 were retrieved from electronic records. All data were retrospectively analyzed. Results A total of 64 liver transplantations, 11 from deceased donors and 53 from living donors, were carried out in our center between 2010 and 2020. The mean age of the recipient was 44 years, 53% were female, and 47% were male. Hepatitis B+hepatitis D infection was the most common cause of end-stage liver disease (21 cases; 32.8%). The overall patient survival rates for 1, 3, and 5 years were 75%, 69.5%, and 59.6%, respectively, for recipients of a liver transplant from a living donor and 54.5%, 45.5%, and 39% for recipients of a liver transplant from a deceased donor. Conclusions Our clinical outcomes had a high rate of biliary and vascular complications that led to a low survival rate of the recipients. Starting the transplant program in Kazakhstan faced various challenges. In the early period, most transplantations were performed in collaboration with or under the guidance of transplant teams from Russia, Turkey, and South Korea. Improving surgical techniques and protocols of pre- and posttransplantation management could reduce the complications after transplantation.

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Examining need and capacity for the development of a pediatric liver transplantation program in Kenya

Muncner

Dell

Mwita³

et al. 2023

Pediatric Transplantation

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Background: In Africa, pediatric liver transplantation (PLT) is currently only performed in Egypt and South Africa, leaving those who require treatment in Kenya to travel abroad. The aim of this study was to determine whether sufficient capacity and need exists in Kenya to establish a safe and sustainable PLT program. Methods:A descriptive analysis of the intensive care unit (ICU) beds, surgical workforce, current hepatobiliary volume, and estimated prevalence of pediatric liver disease (PLD) was conducted across 17 hospitals in Kenya between July and September 2020. Data were collected from medical superintendents, directors of surgical departments, or nominated proxies at Kenyan Level 5 and 6 hospitals via a web-based survey.Results: A total of 165 ICU beds were reported at 17 facilities, with 15 facilities reporting five or more beds. About 39% of general surgeons at responding hospitals performed hepatobiliary procedures, and 30% performed pediatric surgeries. Only 10% of surgeons had pediatric training. Over half (57%) of hospitals performed hepatobiliary procedures; at the maximum, 1-5 cases were performed per week including cholecystectomy to Kasai portoenterostomy and hepatectomy. Across 13 hospitals, there were an estimated 192-570 cases of PLD seen per month. The most common PLDs were hepatitis B, neonatal hepatitis, cirrhosis, and acute hepatic failure. Overall, two hospitals possessed the minimum workforce and resources to attempt PLT. Conclusions:In Kenya, ICU bed availability, pediatric surgical training, and hepatobiliary volume are limited. However, the high prevalence of PLD demonstrated a significant need for PLT across all Kenyan hospitals.

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Cited by 3 publications

References 1 publication

Epidemiological Characteristics of Chronic Viral Hepatitis in Kazakhstan: Data from Unified Nationwide Electronic Healthcare System 2014–2019

Epidemiological Characteristics of Chronic Viral Hepatitis in Kazakhstan: Data from Unified Nationwide Electronic Healthcare System 2014–2019

Liver Transplantation: A 10-Year Low-Volume Transplant Center Experience in Kazakhstan

Examining need and capacity for the development of a pediatric liver transplantation program in Kenya

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