Eag1 K⁺ Channel: Endogenous Regulation and Functions in Nervous System

Abstract

Ether-à-go-go1 (Eag1, Kv10.1, KCNH1) K+ channel is a member of the voltage-gated K+ channel family mainly distributed in the central nervous system and cancer cells. Like other types of voltage-gated K+ channels, the EAG1 channels are regulated by a variety of endogenous signals including reactive oxygen species, rendering the EAG1 to be in the redox-regulated ion channel family. The role of EAG1 channels in tumor development and its therapeutic significance have been well established. Meanwhile, the importance of hEAG1 channels in the nervous system is now increasingly appreciated. The present review will focus on the recent progress on the channel regulation by endogenous signals and the potential functions of EAG1 channels in normal neuronal signaling as well as neurological diseases.

Ether‐à‐go‐go K+ channels: effective modulators of neuronal excitability

“…In addition, eag1 channels are affected by other signalling substances such as arachidonic acid, oestrogen or progesterone (Han et al . ). In heteromeric eag channels the slow time course of eag2 activation dominates (Schonherr et al .…”

The developmental and genetic architecture of the sexually selected male ornament of swordtails

“…Voltage gated channels of the EAG family are inhibited by intracellular calcium [58]. One function of Fkpb9 besides acting as a prolyl cis-trans isomerase is mediated through its calcium binding Ef-H domain [59].…”

Capturing the Interaction Kinetics of an Ion Channel Protein with Small Molecules by the Bio-layer Interferometry Assay

“…The human Ether à go-go channels (hEAG1) are expressed in various types of cancer cells and central nervous system which makes the channel a potential therapeutic target of many cancers and neuronal disorders 10,11,12,13,14 . The electrophysiological study in our lab has confirmed the inhibitory effect of phosphatidylinositol 4, 5-bisphosphate (PIP 2 ) on hEAG1 channel 15 .…”