Eales Disease—An Update

Intravitreal triamcinolone acetonide in Eales' disease: a case report

“…1 Although oral corticosteroid achieves effective intraocular concentration, it is associated with systemic complications. Patients with history of peptic ulcer may experience aggravation of symptoms even with conventional dose of oral corticosteroid.…”

“…1 The endophthalmitis may progress to panophthalmitis if medical or surgical therapy cannot control the infection.…”

A comparative study of epiretinal membranes associated with Eales' disease: a clinicopathologic evaluation

“…[1][2][3][4][5][6][7][8][9][10] It is regarded as a clinical syndrome presenting with retinal perivasculitis affecting the peripheral retina (inflammatory stage), resulting in sclerosis of the retinal vessels (obliterative stage) and finally retinal neovascularization and recurrent vitreous haemorrhage (ischaemic stage), with or without retinal detachment (angiogenesis/ proliferative stage). 5,6,8,10 The treatment strategies involve oral corticosteroids in the inflammatory stage, photocoagulation in the ischaemic stage, and vitrectomy and epiretinal membrane (ERM) removal with additional procedures in the proliferative stage. 5,6 ERMs, in general, are the result of proliferation and differentiation of different cell types.…”

“…5,6,8,10 The treatment strategies involve oral corticosteroids in the inflammatory stage, photocoagulation in the ischaemic stage, and vitrectomy and epiretinal membrane (ERM) removal with additional procedures in the proliferative stage. 5,6 ERMs, in general, are the result of proliferation and differentiation of different cell types. They include retinal pigment epithelium (RPE) and retinal glial cells in proliferative vitreoretinopathy (PVR), vascular endothelium, fibroblasts, and macrophages in retinal vasoproliferative disorders such as diabetic retinopathy and vascular occlusions and blood cellular components in inflammatory disorders.…”

Proliferative vitreoretinopathy developed in HLA-B27-associated uveitis

“…It is uncommon in Eales disease that anterior uveitis and dense vitritis exist as seen in our case. 4 This patient and his father have HLA-B27, which is possessed only in 0.8% of the Japanese population. 1 His father had a past history of unknown uveitis.…”