Ear, nose, and throat involvement in <scp>E</scp>gyptian patients with pemphigus vulgaris: a step towards a better management

Fawzy, Marwa M.; Hegazy, Rehab A.; Fattah, Ahmed F. Abdel

doi:10.1111/j.1365-4632.2012.05846.x

Cited by 9 publications

(27 citation statements)

References 14 publications

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“…Furthermore, it is difficult to use symptoms alone to differentiate between CS subtypes, such as CS with nasal polyps and CS without nasal polyps [15]. Sometimes, ENT disorders are linked with other systemic illness like pemphigus vulgaris [16]. For Bangladesh, it may be important to consider ENT problems related to zoonotic diseases [17].…”

Section: Introductionmentioning

confidence: 99%

Pattern of ear nose and throat diaseses in a tertiary hospital of Dhaka city

et al. 2018

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Background and objectives: The magnitude of health problems related to ear, nose and throat (ENT) in Bangladesh has not been estimated in a larger scale and very little is known about the prevalence and types of ENT diseases. Some studies, however, addressed the prevalence of otitis among school children and very few of them reported hearing defect. This study aims to assess the overall types of ENT diseases encountered by the otolaryngologists at a referral or tertiary hospital.

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Section: Introductionmentioning

confidence: 99%

Pattern of ear nose and throat diaseses in a tertiary hospital of Dhaka city

et al. 2018

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“…Moreover, concomitant bacterial or fungal infection may lead to mucosal inflammation and contribute to NT symptoms. In line with this, positive bacterial and/or fungal cultures have been reported in 18–37% of patients . Therefore, the sum of all these factors might explain why the severity of mucosal involvement is not always a reflection of overall disease severity in PV, nor is it not related to the type of PV …”

Section: Nt Involvement In Pvmentioning

confidence: 81%

“…An interesting question is whether endoscopic procedures in PV should be performed in both symptomatic and asymptomatic patients. While several studies confirm a significant association between nasal and pharyngeal symptoms with involvement of these anatomical areas, such an association is lacking between laryngeal symptoms and presence of lesions in larynx (Table ). Therefore, we believe endoscopic procedures should be performed in all PV patients, regardless of whether they present NT symptoms or not …”

Section: Nt Involvement In Pvmentioning

confidence: 99%

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Exploring beyond the oral mucosa in patients affected with autoimmune blistering diseases: the importance of endoscopic procedures

España

Fernández

2016

Acad Dermatol Venereol

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Autoimmune blistering diseases (AIBD) comprise several entities characterized by the presence of autoantibodies targeted against structural proteins either in desmosomes or in the dermoepidermal junction of polystratified squamous epithelium. Patients develop blisters, erosions in cutaneous surfaces or mucosas. Diagnosis is based on the characteristic mucocutaneous lesions, the typical findings on histological studies and direct immunofluorescence assays, and the presence of specific autoantibodies against the epidermal antigens. It may not be possible for dermatologists to appropriately explore the nose and throat (NT). Thus, a clinical exploration by endoscopic procedures of NT may be a useful tool during the conventional dermatological exam. The aims of this review are to draw attention to the most frequent NT manifestations in AIBD patients, and underline the utility of endoscopic procedures to achieve a more successful and rationale management of patients. Additionally, we will provide brief information related to the anatomical structures and type of epithelium in NT areas which may explain the extent and type of NT involvement in AIBD. Endoscopic exploration in AIBD patients is important for several reasons. Firstly, it will allow the real NT mucosal involvement in each patient to be determined, thus making a differential diagnosis during the endoscopic exam possible, based on the localization of mucosal lesions. Secondary mucosal morbidity can also be ruled out. Secondly, the clinical response to treatment may be established, especially in NT mucosa, as these are anatomical areas subjected to important local traumas, and physiological functions such as breathing, swallowing, speech production and phonation may be damaged. Therefore, a multidisciplinary management in AIBD is mandatory by both dermatologists and otorhinolaryngologists, adding the clinical exploration by endoscopic procedures of NT to the conventional dermatological exam in all AIBD patients, irrespective of whether they exhibit associated symptoms.

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“…A total of 31 different citation hits related to the terms used in the electronic literature search were retrieved. After critical screening of titles, abstracts and full text, 13 articles with a total of 3046 patients with pemphigus, conducted in 10 countries, were suitable in this review . The characteristics of each individual study associated with cigarette smoking and pemphigus are shown in Table .…”

Section: Resultsmentioning

confidence: 99%

Influence of cigarette smoking on pemphigus – a systematic review and pooled analysis of the literature

Lai

Recke

Zillikens

et al. 2018

Acad Dermatol Venereol

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Epidemiological evidence suggests that smoking cigarettes may be beneficial in pemphigus, but no systematic evaluation exists to corroborate this assumption. Therefore, a systematic literature review with pooled data analysis of the smoking status in patients with pemphigus was conducted. Electronic searches using PubMed from inception to November 2017 identified 13 reports meeting predetermined inclusion and exclusion criteria. Most were case-control studies partly reporting that pemphigus vulgaris and foliaceus occurred less frequently in current and former smokers. Studies also indicated that duration of smoking and number of cigarettes smoked were lower in patients with pemphigus than controls and that remission may be achieved sooner in those who smoke. However, although a generally low prevalence of smoking was demonstrated in patients with pemphigus, which was lower than in controls by pooled analysis, some investigations found no difference regarding the smoking status compared with non-pemphigus subjects. One study demonstrated more severe mucosal involvement in non-smoking patients with pemphigus, whereas another observed no difference in the rate of cutaneous or mucosal lesions between smokers and non-smokers with pemphigus. This review indicates that smoking may be a possible protective factor in pemphigus, although some compromised study methodologies yet hinder any firm conclusion. Further investigations with a refined quality design are required to resolve the so far partly conflicting results in this area.

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Ear, nose, and throat involvement in Egyptian patients with pemphigus vulgaris: a step towards a better management

Abstract: Full ENT examination as a routine for all patients with PV could be of great value, as it would lead to more accurate diagnosis, therefore improved management.

Cited by 9 publications

References 14 publications

Pattern of ear nose and throat diaseses in a tertiary hospital of Dhaka city

Pattern of ear nose and throat diaseses in a tertiary hospital of Dhaka city

Exploring beyond the oral mucosa in patients affected with autoimmune blistering diseases: the importance of endoscopic procedures

Influence of cigarette smoking on pemphigus – a systematic review and pooled analysis of the literature

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