Ear of stimulation determines schizophrenia-normal brain activity differences in an auditory paired-stimuli paradigm

Clementz, Brett A.; Dzau, Jacqueline R.; Blumenfeld, Laura D.; Matthews, Scott C.; Kißler, Johanna

doi:10.1016/s0920-9964(03)81267-7

Cited by 13 publications

(18 citation statements)

References 24 publications

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“…The auditory M100 to nonverbal stimuli is typically stronger in right hemisphere among younger adults (Chait et al 2004;Clementz et al 2003;Hertrich et al 2004;Tervaniemi and Hugdahl 2003), a finding that was replicated in the present study. In contrast, the older adults had similar source strengths in left and right hemispheres to these same stimuli.…”

Section: Discussionsupporting

confidence: 84%

“…There is some inconsistency in the literature on the laterality of the auditory M50 to nonverbal auditory stimuli, but the auditory M100 to nonverbal stimuli is typically strongly right hemisphere lateralized in younger healthy adults (Chait et al 2004;Clementz et al 2003;Hertrich et al 2004). This pattern is not surprising given the theoretical importance of right hemisphere for identifying salient features and determining the task relevance of sensory events (e.g., Corbetta and Shulman 2002;Downar et al 2001;Pardo et al 1991;Pugh et al 1996;Tzourio et al 1997).…”

Section: Introductionmentioning

confidence: 99%

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Age-Associated Hemispheric Asymmetry Reduction on the Auditory M100 to Nonverbal Stimuli

Gao

Boyd

Poon

et al. 2007

Brain Imaging and Behavior

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The current study investigated normal aging associated differences on hemispheric laterality of sensory responses to nonverbal auditory stimuli using magnetoencephalography. Twelve older and 12 younger adults with normal hearing thresholds participated. The spatial locations, latencies, and strengths of evoked field M50 and M100 were quantified by equivalent current dipole modeling. No differences were found on M50 or M100 dipole latencies. Older adults had stronger M50 sources bilaterally than younger adults. This difference may be attributable to a decrease in central nervous system inhibitory capacities during normal aging. Older adults also had reduced hemispheric asymmetry on M100 dipole locations and strengths; younger adults had stronger M100 in right than left hemisphere, whereas older adults did not show this expected hemispheric asymmetry. These results indicate that the HAROLD model (Hemispheric Asymmetry Reduction in Older Adults) applies at the level of initial sensory processing.

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Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Age-Associated Hemispheric Asymmetry Reduction on the Auditory M100 to Nonverbal Stimuli

Gao

Boyd

Poon

et al. 2007

Brain Imaging and Behavior

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“…Similarly, the N100 also exhibits a pattern of suppression to repeated stimuli. Schizophrenia subjects generally exhibit less sensory gating than healthy subjects for both of these MLAERs (Boutros et al, 2004; Clementz et al, 2003; Clementz, 1998; Clementz et al, 1997; Patterson et al, 2007). Such findings are hypothesized to reflect neuronal gating deficits in schizophrenia that may cause sensory inundation and ‘flooding’ (Bunney et al, 1999); however much remains to be understood about the neuronal and cognitive mechanisms that influence sensory gating.…”

Section: Introductionmentioning

confidence: 99%

Event-related potential abnormalities in schizophrenia: A failure to “gate in” salient information?

Brenner

Kieffaber

Clementz

et al. 2009

Schizophrenia Research

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Sensory gating refers to the central nervous system’s ability to filter sensory inputs, and can be measured by comparing the suppression of event-related brain potential (ERP) amplitudes in a paired auditory stimulus procedure. Poor gating scores in schizophrenia may be caused by abnormal responses to the first (S1), the second (S2) or both of the paired stimuli. However, since S1 and S2 responses may index separate psychological phenomenon, corresponding to the ability to “gate in” and “gate out” sensory stimuli respectively, the precise mechanism affected in schizophrenia remains unclear. To examine the extent to which saliency processing abnormalities may contribute to S1 response deficits, standard and rare (15% probability) paired stimuli were presented to 21 participants with schizophrenia and 22 healthy controls. P50 and N100 ERP amplitude as well as low, beta and gamma frequency power were measured to examine the time course and relative contributions of oscillatory activity affecting auditory processing in schizophrenia. In this study, schizophrenia patients exhibited less evoked beta 1 power (12–20 Hz) in response to salient stimuli at S1, and lower N100 amplitude in response to all S1 stimuli. No group differences were found in the low, beta 2 (20–30 Hz), or gamma frequency ranges. These findings suggest aberrant sensory processing during stages of stimulus evaluation and saliency detection in schizophrenia.

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“…Around the time of N1, ERPs recorded at the scalp corresponded to the amount of direct input, such that bilateral and contralateral responses were stronger than ipsilateral responses in both hemispheres. MNE source analyses demonstrated, however, that right hemisphere tended to be more equally engaged regardless of ear of stimulation, while left hemisphere activity depended more on the afferent path from ear to cortex (see also Clementz, Dzau, Blumenfeld, Matthews, & Kissler, 2003 for a similar effect with MEG data).…”

Section: Discussionmentioning

confidence: 76%

“…The present study found: 1) consistently stronger target-specific cortical activity in right temporal and parietal areas, 2) significant differences as a function of ear of stimulation over temporo-parietal cortices for N1 (cf. Clementz et al, 2003), 3) consistently stronger cortical activity in right hemisphere temporal, parietal, and frontal areas beginning around the time of P2/N2, and 4) right lateralized scalp potentials at the time of P3b regardless of which ear received stimulation. This pattern may be related to recent descriptions of a right hemisphere temporal-parietal/prefrontal cortex network associated with sustained attention, working memory, and the abilities to identify salient features of incoming stimuli and determine their task-relevance (Corbetta & Shulman, 2002; Downar, Crawley, Mikulis, & Davis, 2001; Pardo, Fox, & Raichle, 1991; Stevens et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Hemispheric differences in auditory oddball responses during monaural versus binaural stimulation

Gilmore

Clementz

Berg

2009

International Journal of Psychophysiology

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Hemispheric lateralization of early event-related potentials (ERPs; e.g. N1) is largely based on anatomy of the afferent pathway; lateralization of later auditory ERPs (P2/N2, P250, P3b) is less clear. Using 257-channel EEG, the present study examined hemispheric laterality of auditory ERPs by comparing binaural and monaural versions of an auditory oddball task. N1 showed a contralateral bias over auditory cortex in both hemispheres as a function of ear of stimulation, although right hemisphere sources were activated regardless of which ear received input. Beginning around N1 and continuing through the time of P3b, right hemisphere temporal-parietal and frontal areas were more activated than their left hemisphere counterparts for stimulus evaluation/comparison and target detection. P250 and P3b component amplitudes, topographies, and source estimations were significantly influenced by ear of stimulation, with right hemisphere activity being stronger. This was particularly true for anterior temporal and inferior frontal sources which were more strongly associated with the later, more cognitive components (P250, P3b). Results are consistent with theories of a right hemisphere network that is prominently involved in sustained attention, stimulus evaluation, target detection, and working memory/context updating.

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Ear of stimulation determines schizophrenia-normal brain activity differences in an auditory paired-stimuli paradigm

Cited by 13 publications

References 24 publications

Age-Associated Hemispheric Asymmetry Reduction on the Auditory M100 to Nonverbal Stimuli

Age-Associated Hemispheric Asymmetry Reduction on the Auditory M100 to Nonverbal Stimuli

Event-related potential abnormalities in schizophrenia: A failure to “gate in” salient information?

Hemispheric differences in auditory oddball responses during monaural versus binaural stimulation

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