Earlier detection of breast cancer by surveillance of women at familial risk

Tilanus-Linthorst, Madeleine M.A.; Bartels, C.C.M.; Obdeijn, A.I.M.; Oudkerk, Matthijs

doi:10.1016/s0959-8049(99)00337-8

Cited by 77 publications

(42 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For women with noninformative genetic test results and/or a positive family history, some screening protocols have been proposed (Pichert et al, 2003). These protocols could lead to an earlier diagnosis of breast cancer at even preclinical stages (Tilanus-Linthorst et al, 2000). We were surprised to find that in Geneva, young breast cancer patients with a strong family history were not diagnosed more frequently by targeted screening.…”

Section: Discussionmentioning

confidence: 99%

“…Others are offered periodic clinical examination and breast imaging (mammography, ultrasound and magnetic resonance imaging). For unaffected women with an unknown or noninformative mutation status, but with a strong family history of breast cancer, intensive surveillance is also highly recommended (Pichert et al, 2003), as it may lead to earlier detection of breast cancer in a more favourable stage (Eccles et al, 2000;Tilanus-Linthorst et al, 2000).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Impact of familial risk factors on management and survival of early-onset breast cancer: a population-based study

et al. 2005

View full text Add to dashboard Cite

This population-based study evaluates the impact of a strong family history of breast cancer on management and survival of women with early-onset disease. We identified all breast cancer patients p50 years, recorded between 1990 and 2001 at the Geneva familial breast cancer registry. We compared patients at high familial risk and low familial risk in terms of tumour characteristics, method of detection, treatment, survival and breast cancer mortality risk. Compared to patients at low familial risk (n ¼ 575), those at high familial risk (n ¼ 58) received significantly more often systemic therapy, especially for node-negative or receptor-positive disease. Five-year disease-specific survival rates of patients at high vs low familial risk were 86 and 90%, respectively. After adjustment, there was no difference in breast cancer mortality in general. A strong family history nonsignificantly increased breast cancer mortality in patients p40 years (adjusted hazard ratio (HR) 4.0, 95% CI 0.8 -19.7) and in patients treated without chemotherapy (adjusted HR 2.7, 95% CI 0.6 -12.5). A strong family history of breast cancer is associated with an increased use of systemic therapy in early-onset patients. Although a strong family history does not seem to affect survival in general, it may impair survival of very young patients and patients treated without adjuvant chemotherapy. Owing to the limited number of patients in this study, these results should be used only to generate hypotheses.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Impact of familial risk factors on management and survival of early-onset breast cancer: a population-based study

et al. 2005

View full text Add to dashboard Cite

show abstract

“…Current applications for breast MRI include evaluation of extent of ipsilateral malignancy [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] and screening of the contralateral breast [4,11,13,15,16,[18][19][20][21][22][23][24][25] in patients with newly diagnosed breast cancer, screening of women at high risk for breast cancer [25][26][27][28][29][30][31][32][33][34] and evaluation of patients with metastatic axillary adenopathy and an unknown primary cancer [35][36][37][38][39][40]. In 2003 the First Edition of the American College of Radiology (ACR) Breast Imaging Reporting and Data System (BI-RADS) MRI lexicon was published, reflecting the significance of this tool in the breast imaging armamentarium …”

Section: Introductionmentioning

confidence: 99%

Probability of malignancy for lesions detected on breast MRI: a predictive model incorporating BI-RADS imaging features and patient characteristics

et al. 2011

View full text Add to dashboard Cite

show abstract

“…A second study, which screened 109 high-risk women with MRI, reported the detection of three breast cancers that were occult at mammography. 66 MRI detected all three cancers in an early (T1 N0) stage. By analyzing a retrospective cohort of 179 high-risk women for over 6 years, Stoutjesdijk et al 67 detected 13 cancers with screening examinations.…”

Section: Screening In High-risk Womenmentioning

confidence: 89%