Earlier Eradication of Intra-Anal Warts with Argon Plasma Coagulator Combined with Imiquimod Cream Compared with Argon Plasma Coagulator Alone: A Prospective, Randomized Trial

Viazis, Nikos; Vlachogiannakos, John; Vasiliadis, Konstantinos; Theodoropoulos, Ioannis; Saveriadis, Adamos; Karamanolis, Dimitrios G.

doi:10.1007/s10350-007-9041-2

Cited by 20 publications

(31 citation statements)

References 19 publications

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“…In a small RCT10 of combined treatment of intra-anal warts with argon plasma coagulation and imiquimod 5% cream versus argon plasma coagulation alone, no statistically significant differences were seen for short-term CC and long-term recurrence (GRADE: moderate). None of the participants experienced pain or dropped out due to AE.…”

Section: Resultsmentioning

confidence: 98%

Anogenital warts and other HPV-associated anogenital lesions in the HIV-positive patient: a systematic review and meta-analysis of the efficacy and safety of interventions assessed in controlled clinical trials

et al. 2017

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Objectives Anogenital warts (AGW, condylomata acuminata) and intraepithelial neoplasia (IEN) do not only impact health and social well-being, they are also associated with considerable costs for the healthcare systems. Immunocompromised and HIV-positive patients carry the highest epidemiological burden of human papillomavirus (HPV) infection and comprise a population specifically susceptible to treatment failures and recurrences. This systematic review aimed at identifying and appraising the available evidence from controlled studies of interventions for the treatment of AGW and IEN in immunocompromised patients. Methods We conducted a comprehensive literature search. The Cochrane Collaboration's tool was used to assess risk of bias in included studies. Our confidence in the (pooled) effect-estimates was evaluated according to the Grading of Recommendations Assessment, Development and Evaluation approach. All evaluations were based on data independently extracted by two review authors. Results Nine randomised controlled trials and two controlled studies were eligible, investigating external AGW, intra-anal and/or vaginal warts, and intra-anal and/or perianal IEN. The identified studies assessed imiquimod, cidofovir, fluorouracil, electrocautery, systemic interferon-α and interferon-β, and the combination of intralesional interferon-α and podophyllin. Four studies combined an ablational intervention with either imiquimod, cidofovir, intralesional or systemic interferon-α. One study investigated an experimental therapeutic vaccination (HPV 16 E7) at different concentrations. Conclusions The quality of the evidence ranged from 'very low' to 'moderate' and was limited by the often small samples. Evidence was available for the efficacy of electrocautery for intra-anal IEN, and imiquimod cream for external AGW. Some further interventions should be subjected to investigations in larger samples. No data on some interventions established for the treatment of AGW in immunocompetent patients such as podophyllotoxin, sinecatechins, laser ablation or trichloroacetate were available. Future trials should address these gaps and include relevant patient-reported outcomes such as health-related quality of life.

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Section: Resultsmentioning

confidence: 98%

Anogenital warts and other HPV-associated anogenital lesions in the HIV-positive patient: a systematic review and meta-analysis of the efficacy and safety of interventions assessed in controlled clinical trials

et al. 2017

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“…Here, although shown to be effective and safe, the procedure was marked by recurrence rates of up to 33 % . A study that compared APC with a combination of APC and imiquimod confirmed the safety and efficacy of APC in the subgroup of HIV‐positive individuals . According to the authors´ opinion, only monofocal AIN or AIN‐lesions located in two quadrants of the anal circumference should be surgically removed, as widespread excision might induce stenosis or strictures.…”

Section: Treatment Of Anal Intraepithelial Neoplasiamentioning

confidence: 96%

German‐Austrian guidelines on anal dysplasia and anal cancer in HIV‐positive individuals: prevention, diagnosis, and treatment

Eßer

Kreuter

Oette

et al. 2015

J Deutsche Derma Gesell

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“…Das Verfahren konnte als effektiv und sicher charakterisiert werden, Rezidive traten aber in bis zu 33 % auf . Eine Studie, die die APC mit einer Kombinationsbehandlung aus APC und Imiquimod verglich, legte in einer Subgruppe Daten zu HIV‐Infizierten vor, die das zu Sicherheit und Effektivität Gesagte bestätigte . Nach Meinung der Autoren sollten nur monofokale bzw.…”

Section: Therapie Der Analen Intraepithelialen Neoplasieunclassified

Deutsch‐Österreichische S2k‐Leitlinie: anale Dysplasien und Analkarzinome bei HIV‐Infizierten: Prävention, Diagnostik und Therapie

Eßer

Kreuter

Oette

et al. 2015

J Deutsche Derma Gesell

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Earlier Eradication of Intra-Anal Warts with Argon Plasma Coagulator Combined with Imiquimod Cream Compared with Argon Plasma Coagulator Alone: A Prospective, Randomized Trial

Abstract: Combination therapy with argon plasma coagulator plus imiquimod cream results in earlier clearance of intra-anal warts in both immunocompetent and immunocompromised patients; however, it does not affect the rate of recurrence.

Cited by 20 publications

References 19 publications

Anogenital warts and other HPV-associated anogenital lesions in the HIV-positive patient: a systematic review and meta-analysis of the efficacy and safety of interventions assessed in controlled clinical trials

Anogenital warts and other HPV-associated anogenital lesions in the HIV-positive patient: a systematic review and meta-analysis of the efficacy and safety of interventions assessed in controlled clinical trials

German‐Austrian guidelines on anal dysplasia and anal cancer in HIV‐positive individuals: prevention, diagnosis, and treatment

Deutsch‐Österreichische S2k‐Leitlinie: anale Dysplasien und Analkarzinome bei HIV‐Infizierten: Prävention, Diagnostik und Therapie

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