Earliest identification of New Delhi metallo-β-lactamase 1 (NDM-1) in Acinetobacter pittii in Brazil

Deglmann, Roseneide Campos; Kobs, Vanessa Cristine; Oliveira, Débora de; Burgardt, Patricia; França, Paulo Henrique Condeixa de; Pillonetto, Marcelo

doi:10.1590/0037-8682-0348-2018

Cited by 8 publications

(5 citation statements)

References 10 publications

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“…The major mechanisms of resistance in CRAP found in Thailand include production of OXA-23 and OXA-58 [ 7 , 8 ]. Apart from bla OXA genes with MBLs, genes such as bla IMP-14a have been reported in CRAP isolates from Thailand, while bla NDM -carrying organisms have been reported in countries like Malaysia, Taiwan, South Korea, Japan, and Brazil, but not in Thailand [ 4 , 6 , 8 , 9 , 10 , 11 ]. Genomic characterization of metallo-β-lactamase harboring A. pittii has not yet been investigated in the isolates from Thailand.…”

Section: Introductionmentioning

confidence: 99%

Genomic Characterization of Clinical Extensively Drug-Resistant Acinetobacter pittii Isolates

et al. 2021

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Carbapenem-resistant Acinetobacter pittii (CRAP) is a causative agent of nosocomial infections. This study aimed to characterize clinical isolates of CRAP from a tertiary hospital in Northeast Thailand. Six isolates were confirmed as extensively drug-resistant Acinetobacter pittii (XDRAP). The blaNDM-1 gene was detected in three isolates, whereas blaIMP-14 and blaIMP-1 were detected in the others. Multilocus sequence typing with the Pasteur scheme revealed ST220 in two isolates, ST744 in two isolates, and ST63 and ST396 for the remaining two isolates, respectively. Genomic characterization revealed that six XDRAP genes contained antimicrobial resistance genes: ST63 (A436) and ST396 (A1) contained 10 antimicrobial resistance genes, ST220 (A984 and A864) and ST744 (A56 and A273) contained 9 and 8 antimicrobial resistance genes, respectively. The single nucleotide polymorphism (SNP) phylogenetic tree revealed that the isolates A984 and A864 were closely related to A. pittii YB-45 (ST220) from China, while A436 was related to A. pittii WCHAP100020, also from China. A273 and A56 isolates (ST744) were clustered together; these isolates were closely related to strains 2014S07-126, AP43, and WCHAP005069, which were isolated from Taiwan and China. Strict implementation of infection control based upon the framework of epidemiological analyses is essential to prevent outbreaks and contain the spread of the pathogen. Continued surveillance and close monitoring with molecular epidemiological tools are needed.

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Section: Introductionmentioning

confidence: 99%

Genomic Characterization of Clinical Extensively Drug-Resistant Acinetobacter pittii Isolates

et al. 2021

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“…Although much less common than bla OXA-23 , the presence of bla NDM in Acinetobacter spp. is another interesting finding, with the first Brazilian isolate detected in Acinetobacter pittii in September 2012 [ 34 ] followed by the detection in 2014 in A. baumannii [ 35 ], Acinetobacter bereziniae [ 36 ], and Acinetobacter nosocomialis [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

A 7-Year Brazilian National Perspective on Plasmid-Mediated Carbapenem Resistance in Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii Complex and the Impact of the Coronavirus Disease 2019 Pandemic on Their Occurrence

Kiffer,

Rezende,

Costa-Nobre

et al. 2023

Clinical Infectious Diseases

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Background Carbapenemase production is a global public health threat. Antimicrobial resistance (AMR) data analysis is critical to public health policy. Here we analyzed carbapenemase detection trends using the AMR Brazilian Surveillance Network. Methods Carbapenemase detection data from Brazilian hospitals included in the public laboratory information system dataset were evaluated. The detection rate (DR) was defined as carbapenemase detected by gene tested per isolate per year. The temporal trends were estimated using the Prais–Winsten regression model. The impact of COVID-19 on carbapenemase genes in Brazil was determined for the period 2015–2022. Detection pre- (October 2017 to March 2020) and post-pandemic onset (April 2020 to September 2022) was compared using the χ2 test. Analyses were performed with Stata 17.0 (StataCorp, College Station, TX). Results 83 282 blaKPC and 86 038 blaNDM were tested for all microorganisms. Enterobacterales DR for blaKPC and blaNDM was 68.6% (41 301/60 205) and 14.4% (8377/58 172), respectively. P. aeruginosa DR for blaNDM was 2.5% (313/12 528). An annual percent increase for blaNDM of 41.1% was observed, and a decrease for blaKPC of −4.0% in Enterobacterales, and an annual increase for blaNDM of 71.6% and for blaKPC of 22.2% in P. aeruginosa. From 2020 to 2022, overall increases of 65.2% for Enterobacterales, 77.7% for ABC, and 61.3% for P. aeruginosa were observed in the total isolates. Conclusions This study shows the strengths of the AMR Brazilian Surveillance Network with robust data related to carbapenemases in Brazil and the impact of COVID-19 with a change in carbapenemase profiles with blaNDM rising over the years.

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“…The first outbreak of bla OXA-23 -producing A. baumannii was described in 1999 in the city of Curitiba, State of Paraná, Brazil, 14 years after the first identification of the enzyme in Scotland. Since then, several studies have identified this pathogen with a similar resistance profile in several Brazilian states [ 16 ]. Results from these investigations revealed that A. baumannii harbored a high prevalence of bla OXA-23 , followed by bla OXA-51 ; bla OXA-143 was found in A. baumannii isolates in Brazil and other Latin American countries [ 12 , 15 , 17 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

Genetic, antimicrobial resistance profile and mortality rates of Acinetobacter baumannii infection in Brazil: A systematic review

Silva

Werlang

Vandresen

et al. 2022

Narra J

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The increase of multidrug-resistant bacteria - including Acinetobacter baumannii (A. baumannii) - has been reported globally. The aim of this systematic review was to determine the risk factors of A. baumannii infection, its resistance profile, reservoirs and mortality rates in Brazil. Data from over 3,000 patients were included. Results suggested that A. baumannii is widely transmitted in Brazil and the endemic clones ST1, ST15, ST 25, ST79, ST162 and ST730 were the most reported; also, blaOXA23, blaOXA51 and blaOXA143 were common resistant genes. The risk factors for A. baumannii infectionincluded the procedure of using invasive devices, previous antibiotic therapy, hemodialysis, comorbidities and higher scores on the Sequential Organ Failure Assessment (SOFA). Two out of five studies identified multidrug resistant A. baumannii to polymyxin. Mortality rates varied between 43.7% to 81%, except for the ST25 strain in which there was a 100% mortality rate. Mortality was associated with sepsis, respiratory infection, septic shock, old age (>60 years) and administration of norepinephrine. Nonetheless, this review highlights the need for more data on A. baumannii infectionacross Brazil to support public policies aiming to control and prevent the dissemination of this bacteria.

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Earliest identification of New Delhi metallo-β-lactamase 1 (NDM-1) in Acinetobacter pittii in Brazil

Cited by 8 publications

References 10 publications

Genomic Characterization of Clinical Extensively Drug-Resistant Acinetobacter pittii Isolates

Genomic Characterization of Clinical Extensively Drug-Resistant Acinetobacter pittii Isolates

A 7-Year Brazilian National Perspective on Plasmid-Mediated Carbapenem Resistance in Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii Complex and the Impact of the Coronavirus Disease 2019 Pandemic on Their Occurrence

Genetic, antimicrobial resistance profile and mortality rates of Acinetobacter baumannii infection in Brazil: A systematic review

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