Early 1,25-Dihydroxyvitamin D&lt;sub&gt;3&lt;/sub&gt; Supplementation Effectively Lowers the Incidence of Type 2 Diabetes Mellitus via Ameliorating Inflammation In KK-A&lt;sup&gt;y&lt;/sup&gt; Mice

Tian, Liqiang; Yu, Yanting; Jin, Mengdi; Duan, Huilian; Huang, Guowei; Zhang, Meilin

doi:10.3177/jnsv.67.84

Cited by 5 publications

(3 citation statements)

References 42 publications

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“…Thus, weight loss interventions play a crucial part in the management of T2DM. Consistent with a previous study [32], our results showed that 1,25(OH) 2 D 3 treatment reduced the fasting blood glucose and insulin levels and ameliorated glucose tolerance and insulin sensitivity. Dyslipidemia is a prevalent comorbidity of T2DM, which is marked by augmented serum TG, TC, and LDL-C levels, and/or lowered HDL-C levels [36].…”

Section: Discussionsupporting

confidence: 93%

“…T2DM is a multi-factor metabolic disorder with growing incidence worldwide [31]. Previous clinical and basic studies indicated that vitamin D might exert beneficial effects on the symptoms or the prevention of T2DM [14,16,17,32]. Furthermore, a latest metaanalysis suggested the beneficial effects of vitamin D on the con- trol of blood glucose in patients with T2DM and the prevention of diabetic complications [33].…”

Section: Discussionmentioning

confidence: 99%

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Vitamin D Alleviates Type 2 Diabetes Mellitus by Mitigating Oxidative Stress-Induced Pancreatic β-Cell Impairment

Liu,

Zhang,

Shi

et al. 2023

Exp Clin Endocrinol Diabetes

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Objective Type 2 diabetes mellitus (T2DM) is a common metabolic disorder with rising incidence worldwide. This study explored the anti-T2DM role of vitamin D, thereby providing novel therapeutic strategies. Methods C57BL/6 J mice and MIN6 cells were used to induce in vivo T2DM and damaged β-cell models, respectively. Body weights, fasting blood glucose, and fasting insulin were measured in mice. Oral glucose tolerance test (OGTT) and insulin tolerance test (ITT) were conducted on mice. Lipid indices (TG, TC, LDL-C, and HDL-C) were detected in mouse serum. Hematoxylin-eosin staining was used to evaluate pancreatic tissue injury. ELISA was used to assess insulin and oxidative stress (OS) markers (MDA, GSH, and SOD) in mice and MIN6 cells. Production of ROS was detected in islet β-cells and MIN6 cells. Cell viability and apoptosis were evaluated using CCK-8 and flow cytometry, respectively. QRT-PCR and western blotting were used to detect pro-inflammatory factors (TNF-α and IL-6) and endoplasmic reticulum stress (ERS) markers (CHOP and GRP78), respectively. Results Vitamin D reduced body weights, fasting blood glucose, and insulin and ameliorated glucose tolerance and insulin sensitivity in T2DM mice. Besides, vitamin D decreased serum TG, TC, LDL-C, and increased HDL-C in T2DM mice. Vitamin D inhibited pancreatic histopathological injury, cell apoptosis, OS, and β-cell decline in T2DM mice. Moreover, vitamin D alleviated cell death, insufficient insulin secretion, inflammation, OS, and ERS in damaged MIN6 cells. Notably, N-acetyl-L-cysteine (an OS inhibitor) enhanced these effects of vitamin D. Conclusions Vitamin D relieved T2DM symptoms by alleviating OS-induced β-cell impairment.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Vitamin D Alleviates Type 2 Diabetes Mellitus by Mitigating Oxidative Stress-Induced Pancreatic β-Cell Impairment

Liu,

Zhang,

Shi

et al. 2023

Exp Clin Endocrinol Diabetes

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“… 17 Early vitamin D supplementation reduced the incidence of T2DM by improving inflammation in KK-Ay mice. 18 Early detection of vitamin D deficiency can be an important factor in preventing T2DM. In addition, the timely detection of vitamin D deficiency and supplementation in people who already have diabetes may be beneficial in improving insulin resistance, maintaining blood glucose homeostasis, and reducing the risk of complications.…”

Section: Discussionmentioning

confidence: 99%

Monocyte/High-Density Lipoprotein Cholesterol Ratio Predicts Vitamin D Deficiency in Male Patients with Type 2 Diabetes Mellitus

Zhao¹,

Deng²,

Li³

et al. 2022

DMSO

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Purpose This study aimed to investigate the relationship between monocyte/high-density lipoprotein cholesterol ratio (MHR) and 25-hydroxyvitamin D [25(OH) D] level in patients with type 2 diabetes mellitus (T2DM), the risk factors for vitamin D deficiency, and the clinical value of MHR as a predictor of vitamin D deficiency in this population. Patients and Methods This was a cross-sectional study of 260 patients with T2DM from May 2021 to October 2021. Based on internationally used criteria for defining vitamin D levels, the patients were divided according to sex and levels of vitamin D into the following four groups: Group A1 (male patients with vitamin D levels <20 ng/mL), group A2 (male patients with vitamin D levels ≥20 ng/mL), group B1 (female patients with vitamin D levels <20 ng/mL), and group B2 (female patients with vitamin D levels≥20 ng/mL). The MHR was calculated as a monocyte/high-density cholesterol lipoprotein ratio. Results The vitamin D level was independently and negatively correlated with the MHR in male patients with T2DM, but not in female patients. The MHR was an independent risk factor and predictor for the development of vitamin D deficiency in male patients, but not in female patients, with T2DM. High-density lipoprotein (HDL) was an independent protective factor for vitamin D deficiency in female patients with T2DM. Conclusion This study suggested that the MHR was a new marker for predicting vitamin D deficiency in male patients with T2DM. Alleviating inflammation, improving lipid metabolism, and increasing HDL levels in patients with T2DM might help improve vitamin D levels, which might be important for preventing and managing T2DM. The MHR might help as a new marker to predict vitamin D deficiency in China, where primary hospitals lack the capacity for vitamin D testing on a large scale.

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Metformin and vitamin D combination therapy ameliorates type 2 diabetes mellitus-induced renal injury in male Wistar rats

Abdulrahim,

Odetayo,

Owootori

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Early 1,25-Dihydroxyvitamin D<sub>3</sub> Supplementation Effectively Lowers the Incidence of Type 2 Diabetes Mellitus via Ameliorating Inflammation In KK-A<sup>y</sup> Mice

Cited by 5 publications

References 42 publications

Vitamin D Alleviates Type 2 Diabetes Mellitus by Mitigating Oxidative Stress-Induced Pancreatic β-Cell Impairment

Vitamin D Alleviates Type 2 Diabetes Mellitus by Mitigating Oxidative Stress-Induced Pancreatic β-Cell Impairment

Monocyte/High-Density Lipoprotein Cholesterol Ratio Predicts Vitamin D Deficiency in Male Patients with Type 2 Diabetes Mellitus

Metformin and vitamin D combination therapy ameliorates type 2 diabetes mellitus-induced renal injury in male Wistar rats

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