Early Adaption to the Antarctic Environment at Dome C: Consequences on Stress-Sensitive Innate Immune Functions

Feuerecker, Matthias; Crucian, Brian; Salam, Alex P.; Rybka, Ales; Kaufmann, Inès; Moreels, Marjan; Quintens, Roel; Schelling, Gustav; Thiel, Manfred; Baatout, Sarah; Sams, Clarence; Choukèr, Alexander

doi:10.1089/ham.2013.1128

Cited by 25 publications

(26 citation statements)

References 34 publications

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“…During the early adaptation phase (1 mo) of the Concordia winter-over crew in 2008, cortisol levels and stress questionnaires did not report higher stress levels. However, 24-h urinary catecholamine excretion was significantly increased (13).…”

Section: Antarctica a Testbed For Real Exploration Type Isolation Comentioning

confidence: 87%

Effects of isolation and confinement on humans-implications for manned space explorations

Pagel¹,

Choukèr²

2016

Journal of Applied Physiology

113

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Human psychology and physiology are significantly altered by isolation and confinement. In light of planned exploration class interplanetary missions, the related adverse effects on the human body need to be explored and defined as they have a large impact on a mission's success. Terrestrial space analogs offer an excellent controlled environment to study some of these stressors during a space mission in isolation without the complex environment of the International Space Station. Participants subjected to these space analog conditions can encounter typical symptoms ranging from neurocognitive changes, fatigue, misaligned circadian rhythm, sleep disorders, altered stress hormone levels, and immune modulatory changes. This review focuses on both the psychological and the physiological responses observed in participants of long-duration spaceflight analog studies, such as Mars500 or Antarctic winter-over. They provide important insight into similarities and differences encountered in each simulated setting. The identification of adverse effects from confinement allows not only the crew to better prepare for but also to design feasible countermeasures that will help support space travelers during exploration class missions in the future.

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Section: Antarctica a Testbed For Real Exploration Type Isolation Comentioning

confidence: 87%

Effects of isolation and confinement on humans-implications for manned space explorations

Pagel¹,

Choukèr²

2016

Journal of Applied Physiology

113

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“…In a previous study, an increase of beta activity in the prefrontal cortex was observed after an acute hypoxic exposure (44). Even though a fast adaptation was shown (16), we cannot exclude that hypoxia might affect our results. In this study we had no baseline recordings before participants’ trip to Antarctica.…”

Section: Discussionmentioning

confidence: 79%

“…Furthermore, the station is at high altitude (3200m) which implies that the crewmembers have to cope with lower oxygen levels (hypoxia) and low air pressure (hypobaria). Because of its location at the South Pole, the atmospheric pressure is equivalent to an altitude of 3800m outside the polar circle (16). Since the oxygen concentration is at 13% instead of the usual 21%, the blood saturation in oxygen is lower, which increase the heart rate.…”

Section: Introductionmentioning

confidence: 99%

“…Hypoxia has shown to impact cognitive performances and sleep quality (17; 18; 19; 20). Fortunately, the adaptation process to high altitude takes place within a few weeks and participants should be acclimated to their new environment for their first measurement (16; 21). Nevertheless, high altitude at Concordia station is a good model of hypoxia and hypobaria conditions encountered during space missions (22).…”

Section: Introductionmentioning

confidence: 99%

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Electrophysiological measures of sleep pressure during wakefulness in the course of isolation at the Concordia Antarctica station and physical activity as a countermeasure

Petit

Abeln

Summerer

et al. 2019

Preprint

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18Concordia station in Antarctica is one of the most remote human outpost on Earth. Because of 19 its geographical location, a winterover at Concordia shares a lot of stressors with a space mission. 20 Following a recent study on the markers of sleep pressure during wakefulness on board of the 21 International Space Station, we were investigating if long term isolation in a space analogue station 22 shows similar effects on sleep pressure. Unlike in space, markers of sleep pressure did not increase 23 during isolation's constant darkness period in Antarctica. When measures of sleep pressure were 24 high in the evening, psychological strain was increased, emphasising the importance of keeping sleep 25 pressure under physiological levels during the mission. As a first indication for a countermeasure, 26 we showed that one hour of bicycle exercise during lunch time could decrease sleep pressure. All 27 these observations need to be further studied in a more controlled environment. 28 Keywords 29Sleep pressure, wake electroencephalographic recordings, Antarctica space analogue station, long 30 term isolation, psychological strain, space countermeasure, physical activity 31 32 Sleep quality and sleep quantity are regulated by two interacting process, the homeostatic and 33 the circadian process (1): i) The homeostatic process builds up with time awake. Good sleep 34 quality is defined by an efficient dissipation of sleep pressure overnight which in turn decreases the 35 propensity to fall asleep and improve alertness the following day (2; 3). ii) The circadian process is 36 oscillating on a 24 hours cycle (4). The master clock is regulated by the suprachiasmatic nucleus 37 and constantly adjusted by environmental cues (5). Daylight is one of the main cues to the master 38 clock. Circadian rhythms exert a strong impact on sleep quality and sleep timing (6). Interestingly, 39 EEG theta activity (5-7Hz) in the waking EEG (1) reflects both the homeostatic and the circadian 40 process. The circadian impact can be seen by diurnal fluctuations of theta activity, peaking in the 41 afternoon and again at bed time (7). The homeostatic component, on the other hand, becomes 42 obvious after prolonged wakefulness (i.e. sleep deprivation), which is associated with a significant 43 increase in theta power. (8; 9; 10; 11; 12). 44Astronauts are subject to very irregular schedules and workloads (e.g. launchings or dockings of 45 a vehicule) and while orbiting Earth, the International Space Station (ISS) crew witness a sun 46 rise every 90 minutes which can lead to a misalignment of their 24-hour sleep-wake cycle (13). 47Accordingly, chronic sleep restriction has been reported during space missions (14). We recently 48 provided first evidence for increased of sleep pressure markers during wakefulness in space, i.e 49 measured waking EEG in the theta frequency range, and showed that reaction times were slower 50 when markers of sleep pressure were high (15). To understand the cause of changes in markers of 51 sleep pressure i...

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“…Ao longo dos últimos 10 anos (2006 a 2017), foram publicados menos de 30 estudos especializados, conforme consulta às bases de dados Web of Science e SCOPUS. As publicações mais recentes focam em estresse e coping (Anton-Solanas, O'Neil, Morris & Dunbar, 2016;Barkaszi, Takács, Czigler & Balázs, 2016); aspectos relacionados ao sono e ao ciclo circadiano (Brockmann et al, 2017;Chen, Wu, Li, Zhang & Xu, 2016;Feuerecker et al, 2014;Morris, Pilcher, & Powell, 2017); e à adaptação ao ambiente polar (Jin, Touyama, Yamada, Yamazaki, & Benno, 2014;Najjar et al, 2014;Pattarini, Scarborough, Sombito, & Parazynski, 2016).…”

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Coping E Padrões Biológicos De Sono Em Expedicionários Antárticos

Barros-Delben

Cruz

Melo

et al. 2019

Psipesq

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O objetivo deste estudo foi avaliar a variação das estratégias de coping e padrões de sono em 13 expedicionários do sexo masculino da aviação naval no início e ao final de uma expedição de verão à Antártica. Para investigar as variáveis de coping e de sono foram utilizadas a escala BriefCOPE, um questionário de ritmos biológicos e um formulário sociodemográfico para controle de variáveis. As estratégias de coping focadas na emoção do tipo disfuncional aumentaram de forma significativa ao longo da exposição e não houve relação entre as alterações nos padrões de sono e as estratégias de coping entre o início e final da exposição ao ambiente. A atenção a fatores psicológicos em ambientes polares pode prevenir acidentes no contexto.

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Early Adaption to the Antarctic Environment at Dome C: Consequences on Stress-Sensitive Innate Immune Functions

Cited by 25 publications

References 34 publications

Effects of isolation and confinement on humans-implications for manned space explorations

Effects of isolation and confinement on humans-implications for manned space explorations

Electrophysiological measures of sleep pressure during wakefulness in the course of isolation at the Concordia Antarctica station and physical activity as a countermeasure

Coping E Padrões Biológicos De Sono Em Expedicionários Antárticos

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