Early adulthood body mass index, cumulative smoking, and esophageal adenocarcinoma survival

Spreafico, Anna; Coate, Linda; Zhai, Rihong; Xu, Wei; Chen, Zhengfei; Chen, Zhuo; Patel, Devalben; Tse, Brandon; Brown, M. Catherine; Heist, Rebecca S.; Dodbiba, Lorin; Teichman, Jennifer; Kulke, Matthew H.; Li, Su; Eng, Lawson; Knox, Jennifer J.; Wong, Rebecca; Darling, Gail; Christiani, David C.; Liu, Geoffrey

doi:10.1016/j.canep.2016.11.009

Cited by 18 publications

(28 citation statements)

References 32 publications

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“…A limited number of studies have investigated the association between tobacco smoking and survival in patients with esophageal adenocarcinoma, and their results are in agreement with our findings [10][11][12][13]. In a meta-analysis by McMenamin et al, these studies were combined and there was no significant difference in survival outcomes when comparing current (HR 0.99 95% CI 0.73-1.36) or former (HR 0.88 95% CI 0.68-1.14) smokers with never smokers, respectively [14].…”

Section: Discussionsupporting

confidence: 92%

“…Although there has been shown to be no association between alcohol consumption and esophageal adenocarcinoma risk [9], it is worthwhile investigating if alcohol consumption plays a role in prognosis as it is an easily modifiable risk factor and is known to have a synergistic effect with cigarette smoking in other cancers. However, only four published studies, including relatively small numbers of patients, have investigated the association between tobacco smoking, alcohol consumption, and esophageal adenocarcinoma survival [10][11][12][13]. Our working group has published a recent meta-analysis combining two of these studies, which demonstrated no significant difference in esophageal adenocarcinoma survival in neveralcohol drinkers compared to moderate alcohol drinkers (HR 1.34 95% CI 0.95-1.89) [14].…”

Section: Introductionmentioning

confidence: 99%

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Alcohol intake, tobacco smoking, and esophageal adenocarcinoma survival: a molecular pathology epidemiology cohort study

McCain¹,

McManus

McQuaid³

et al. 2019

Cancer Causes Control

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Purpose To investigate the association between cigarette smoking, alcohol consumption, and esophageal adenocarcinoma survival, including stratified analysis by selected prognostic biomarkers. Methods A population-representative sample of 130 esophageal adenocarcinoma patients (n = 130) treated at the Northern Ireland Cancer Centre between 2004 and 2012. Cox proportional hazards models were applied to evaluate associations between smoking status, alcohol intake, and survival. Secondary analyses investigated these associations across categories of p53, HER2, CD8, and GLUT-1 biomarker expression. Results In esophageal adenocarcinoma patients, there was a significantly increased risk of cancer-specific mortality in ever, compared to never, alcohol drinkers in unadjusted (HR 1.96 95% CI 1.13-3.38) but not adjusted (HR 1.70 95% CI 0.95-3.04) analysis. This increased risk of death observed for alcohol consumers was more evident in patients with normal p53 expression, GLUT-1 positive or CD-8 positive tumors. There were no significant associations between survival and smoking status in esophageal adenocarcinoma patients. Conclusions In esophageal adenocarcinoma patients, cigarette smoking or alcohol consumption was not associated with a significant difference in survival in comparison with never smokers and never drinkers in fully adjusted analysis. However, in some biomarker-selected subgroups, ever-alcohol consumption was associated with a worsened survival in comparison with never drinkers. Larger studies are needed to investigate these findings, as these lifestyle habits may not only be linked to cancer risk but also cancer survival.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Alcohol intake, tobacco smoking, and esophageal adenocarcinoma survival: a molecular pathology epidemiology cohort study

McCain¹,

McManus

McQuaid³

et al. 2019

Cancer Causes Control

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“…Detailed descriptions of recruitment procedures can be found in studyspecific publications. 32,[37][38][39][40][41][42][43][44][45][46][47][48] Institutional review board or research ethics committee approval was obtained by each sponsoring institution.…”

Section: Study Design and Populationmentioning

confidence: 99%

Diabetes in relation to Barrett’s esophagus and adenocarcinomas of the esophagus: A pooled study from the International Barrett’s and Esophageal Adenocarcinoma Consortium

Petrick

Anderson³

et al. 2019

Cancer

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Background Diabetes is positively associated with various cancers, but its relationship with tumors of the esophagus/esophagogastric junction remains unclear. Methods Data were harmonized across 13 studies in the International Barrett’s and Esophageal Adenocarcinoma Consortium, comprising 2309 esophageal adenocarcinoma (EA) cases, 1938 esophagogastric junction adenocarcinoma (EGJA) cases, 1728 Barrett's esophagus (BE) cases, and 16,354 controls. Logistic regression was used to estimate study‐specific odds ratios (ORs) and 95% CIs for self‐reported diabetes in association with EA, EGJA, and BE. Adjusted ORs were then combined using random‐effects meta‐analysis. Results Diabetes was associated with a 34% increased risk of EA (OR, 1.34; 95% CI, 1.00‐1.80; I2 = 48.8% [where 0% indicates no heterogeneity, and larger values indicate increasing heterogeneity between studies]), 27% for EGJA (OR, 1.27; 95% CI, 1.05‐1.55; I2 = 0.0%), and 30% for EA/EGJA combined (OR, 1.30; 95% CI, 1.06‐1.58; I2 = 34.9%). Regurgitation symptoms modified the diabetes‐EA/EGJA association (P for interaction = .04) with a 63% increased risk among participants with regurgitation (OR, 1.63; 95% CI, 1.19‐2.22), but not among those without regurgitation (OR, 1.03; 95% CI, 0.74‐1.43). No consistent association was found between diabetes and BE. Conclusions Diabetes was associated with increased EA and EGJA risk, which was confined to individuals with regurgitation symptoms. Lack of an association between diabetes and BE suggests that diabetes may influence progression of BE to cancer.

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“…This association is consistent with findings from previous meta analyses such as HR 1.41 (95% CI 1.22,1.64) [21] for smoking status at time of diagnosis in mainly ESCC patients and HR 1.19 (95% CI 1.04,1.36) for ever smoking [4] in ESCC (although no evidence of association in EAC). Some more recently published studies found similar statistically significant HRs including HR = 1.28 [22] and HR = 1.34 [23] both from China, and HR = 1.22 from a study across two sites in US and Canada [24]. In contrast, recent results from Japan HR = 0.97 [25] failed to find evidence of association between pre-diagnosis smoking and post-diagnosis survival time.…”

Section: Discussionmentioning

confidence: 80%

“…One review found pre-diagnosis obesity could be associated with higher risks of death in cancer (specifically breast, prostate and colorectal cancers) [27] but a later study reported that pre-diagnostic obesity increased hazard for all cancers except cancers of the upper digestive tract (obese compared to normal weight HR 0.87, 95% CI 0.62,1.22) [28]. More recently a North American study [24] found recalled obesity in early adulthood was associated with lower survival times than normal weight (HR 1.77, 95% CI 1.25, 2.51). The measure of obesity available in this study may not be optimal.…”

Section: Discussionmentioning

confidence: 99%

Using estimated probability of pre-diagnosis behavior as a predictor of cancer survival time: an example in esophageal cancer

Fahey

Page

Stone

et al. 2020

BMC Med Res Methodol

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Background: Information on the associations between pre-diagnosis health behavior and post-diagnosis survival time in esophageal cancer could assist in planning health services but can be difficult to obtain using established study designs. We postulated that, with a large data set, using estimated probability for a behavior as a predictor of survival times could provide useful insight as to the impact of actual behavior. Methods: Data from a national health survey and logistic regression were used to calculate the probability of selected health behaviors from participant's demographic characteristics for each esophageal cancer case within a large cancer registry data base. The associations between survival time and the probability of the health behaviors were investigated using Cox regression. Results: Observed associations include: a 0.1 increase in the probability of smoking 1 year prior to diagnosis was detrimental to survival (Hazard Ratio (HR) 1.21, 95% CI 1.19,1.23); a 0.1 increase in the probability of hazardous alcohol consumption 10 years prior to diagnosis was associated with decreased survival in squamous cell cancer (HR 1.29, 95% CI 1.07, 1.56) but not adenocarcinoma (HR 1.08, 95% CI 0.94,1.25); a 0.1 increase in the probability of physical activity outside the workplace is protective (HR 0.83, 95% CI 0.81,0.84). Conclusions: We conclude that probability for health behavior estimated from demographic characteristics can provide an initial assessment of the association between pre-diagnosis health behavior and post-diagnosis health outcomes, allowing some sharing of information across otherwise unrelated data collections.

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Early adulthood body mass index, cumulative smoking, and esophageal adenocarcinoma survival

Cited by 18 publications

References 32 publications

Alcohol intake, tobacco smoking, and esophageal adenocarcinoma survival: a molecular pathology epidemiology cohort study

Alcohol intake, tobacco smoking, and esophageal adenocarcinoma survival: a molecular pathology epidemiology cohort study

Diabetes in relation to Barrett’s esophagus and adenocarcinomas of the esophagus: A pooled study from the International Barrett’s and Esophageal Adenocarcinoma Consortium

Using estimated probability of pre-diagnosis behavior as a predictor of cancer survival time: an example in esophageal cancer

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