Early‐age body size, adult weight gain and endometrial cancer risk

Marchand, Loı̈c Le; Wilkens, Lynne R.; Mi, Ming-Pi

doi:10.1002/ijc.2910480603

Cited by 62 publications

(49 citation statements)

References 23 publications

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“…Some misclassification of disease site may have occurred but would have been more likely to attenuate than spuriously to create associations. Finally, the validity of our record linkage procedure and the quality of our population database have been demonstrated, z, 8 In summary, the present study provides further evidence for an association of obesity with colon cancer in men and suggests that this association is limited to the sigmoid colon and is related to both early and late events of colon carcinogenesis.…”

Section: Discussionmentioning

confidence: 66%

Obesity in youth and middle age and risk of colorectal cancer in men

Marchand

Wilkens²,

Mi³

1992

Cancer Causes Control

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117

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To investigate an association between colon cancer and obesity during early adulthood--a potentially important period in the etiology of this disease--the authors assembled, by computer linkage, a population-based historical cohort of 52,539 men born between 1913 and 1927 residing in Hawaii (USA), for whom weight and height had been recorded in 1942-43 and 1972. Linkage of this cohort to the Hawaii Tumor Registry resulted in the identification of 737 incident cases of colorectal cancer for 1972-86. An average of 3.8 cancer-free controls were matched to each case on month and year of birth and ethnicity of the parents. A case-control analysis in each anatomic subsite of the large bowel revealed that both early and middle-age body mass increased the risk of sigmoid cancer in men in a dose-dependent fashion. The odds ratios (OR) for sigmoid cancer for the highest compared with the lowest tertiles of Quetelet index were: 2.1 (95 percent confidence interval [CI] = 1.4-3.2) and 1.7 (CI = 1.1-2.5), at ages 15-29 and in prediagnostic years, respectively. These associations were additive and independent of socioeconomic status. Men who were above the median Quetelet index in 1942 and 1972 had an OR of 2.7 (CI = 1.8-4.0), compared with those who were below the median in both periods. This study provides further evidence for an association of obesity with colon cancer in men and suggests that this association is limited to the sigmoid colon and may be related to both early and late events of colon carcinogenesis.

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Section: Discussionmentioning

confidence: 66%

Obesity in youth and middle age and risk of colorectal cancer in men

Marchand

Wilkens²,

Mi³

1992

Cancer Causes Control

Self Cite

117

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“…Our findings regarding BMI at age 18 years are consistent with data from the remaining studies (21,(24)(25)(26) reporting that the association with early age BMI is either no longer statistically significant (24)(25)(26) or null (21) after adjustment for baseline BMI. Additional four studies (7,9,19,22) showed a nonsignificant positive association, but those studies did not adjust for current BMI.…”

Section: Bmi At Different Life Stages and Endometrial Cancermentioning

confidence: 96%

“…Several studies reported a statistically significant (7,9,10,12,(19)(20)(21) or marginally significant (22) positive relation between adult weight gain and endometrial cancer risk, showing a 2-to 6-fold increased risk with increasing level of weight gain. Adult weight gain has not always been consistently defined in these studies but has generally encompassed weight gain from age 18 years to current ages.…”

Section: Cancer Epidemiol Biomarkers Prev 2007;16(4) April 2007mentioning

confidence: 99%

Lifetime Weight History and Endometrial Cancer Risk by Type of Menopausal Hormone Use in the NIH-AARP Diet and Health Study

Chang

Lacey

Brinton

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

102

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Obesity and menopausal estrogen therapy are established risk factors for endometrial cancer. However, the joint effects of obesity and menopausal hormone therapy on endometrial cancer risk are incompletely understood. We addressed this issue in a cohort of 103,882 women ages 50 to 71 years at baseline in 1995 to 1996. During a median of 4.6 years, which contributed to a total of 455,304 person-years of follow-up through 2000, 677 cases of endometrial cancer were ascertained. Both baseline body mass index (BMI) and adult weight gain were associated with increased endometrial cancer risk. The multivariate relative risk (RR) comparing obese with normal weight women (BMI >30 versus <25 kg/ m 2 ) was 3.03 [95% confidence interval (95% CI), 2.50-3.68]. Compared with women with stable weight (gained or lost <5 kg) between age 18 and baseline, women who gained z20 kg had a RR of 2.75 (95% CI, 1.96-3.86). Menopausal hormone therapy significantly modified the relations of BMI (P interaction < 0.001) and adult weight gain (P interaction = 0.004) to endometrial cancer risk. Compared with normal weight, the RRs for obesity were 5.41 (95% CI, 4.01-7.29) among women who never used menopausal hormone therapy, 2.53 (95% CI, 1.21-5.30) among former menopausal hormone therapy users, and 1.44 (95% CI, 1.00-2.05) among current users. Compared with a stable weight between age 18 and baseline, the RRs for weight gain of z20 kg among never users and ever users of menopausal hormone therapy were 5.35 (95% CI, 3.01-9.52) and 1.43 (95% CI, 0.96-2.15), respectively. We conclude that both current adiposity and adult weight gain are associated with substantial increases in the risk of endometrial cancer, with relations particularly evident among never users of menopausal hormone therapy. (Cancer Epidemiol Biomarkers Prev 2007;16(4):723 -30)

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“…1 Expanding knowledge of the importance of exposures throughout the life course 2 has encouraged investigations of relationships between preadult body mass index (BMI) and later cancer risk. [3][4][5][6][7][8][9] With rising levels of childhood adiposity evident in the developed world, 10,11 a clear understanding of the long-term impact on adult health is crucial. As obese children tend to become obese adults, 12 the prevention of overweight in childhood may minimise obesity-related disease in adulthood.…”

mentioning

confidence: 99%

Childhood body mass index and later cancer risk: A 50‐year follow‐up of the Boyd Orr study

Jeffreys

Smith

Martin

et al. 2004

Intl Journal of Cancer

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Associations between childhood BMI and adult cancer risk were investigated in a historical cohort study based on the Carnegie ("Boyd Orr") Survey of Diet and Health in PreWar Britain (1937-9). In 14 centres in England and Scotland, children had their height and weight measured. We included 2,347 individuals aged between 2 and 14 years 9 months at the time of measurement, who were traced through the National Health Service Central Register. Relative cancer risk (registration or death) was estimated in relation to ageand sex-specific BMI SD scores. We studied associations with (i) all cancers, (ii) cancer groups stratified according to their relationship to smoking and (iii) certain site-specific cancers. In the 50 years of follow-up, 188 men and 192 women developed cancer. There was a 9% increase (95% CI -3 to 22%) in risk of cancer in adulthood per SD increase in BMI measured in childhood. There was no evidence of confounding by childhood or adulthood socioeconomic position, other anthropometric variables, childhood energy intake or birth order. There was a 30% increase (95% CI 10 -54%) in risk of smokingrelated cancers per SD increase in childhood BMI. There was no relationship between BMI and cancers not related to smoking. Associations for all cancers and non-smoking-related cancers tended to be stronger in children who were measured at an older (>8 years) rather than a younger (<8 years) age. We conclude that childhood BMI is related to increased risk of cancer in later life, particularly smokingrelated cancers. © 2004 Wiley-Liss, Inc. Key words: body mass index; life course epidemiology; cancer riskAdults who are overweight have higher risks of several cancers. 1 Expanding knowledge of the importance of exposures throughout the life course 2 has encouraged investigations of relationships between preadult body mass index (BMI) and later cancer risk. [3][4][5][6][7][8][9] With rising levels of childhood adiposity evident in the developed world, 10,11 a clear understanding of the long-term impact on adult health is crucial. As obese children tend to become obese adults, 12 the prevention of overweight in childhood may minimise obesity-related disease in adulthood. 13 Most studies of associations between childhood weight and adult cancer risk use recalled measures of weight or comparative body shape. Contemporaneous anthropometry excludes the possibility of misclassification and thus should provide more reliable evidence on relationships between childhood BMI and adult cancer. We explored these relationships using BMI calculated from measured height and weight recorded in the Carnegie Survey of Family Diet and Health in Pre-War Britain. 14,15 MATERIAL AND METHODSThe Carnegie ("Boyd Orr") Survey was a cross-sectional study of diet, social circumstances and health carried out in 1,352 families in 16 districts in Britain between 1937 and 1939. It included 4,999 children aged under 19 years. Childhood anthropometry was recorded for 3,156 subjects (63%) from 1,072 families. Children were weighed, either naked or in ...

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Early‐age body size, adult weight gain and endometrial cancer risk

Cited by 62 publications

References 23 publications

Obesity in youth and middle age and risk of colorectal cancer in men

Obesity in youth and middle age and risk of colorectal cancer in men

Lifetime Weight History and Endometrial Cancer Risk by Type of Menopausal Hormone Use in the NIH-AARP Diet and Health Study

Childhood body mass index and later cancer risk: A 50‐year follow‐up of the Boyd Orr study

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