Early Age-Related Macular Degeneration in Patients with Myocardial Infarction

Liutkevičienė, Rasa; Lesauskaitė, Vaiva; Žaliūnienė, Dalia; Žaliaduonytė-Pekšienė, Diana; Cimbalas, Andrius; Jašinskas, Vytautas; Gustienė, Olivija; Šimonytė, Sandrita; Tamošiūnas, Abdonas

doi:10.3109/02713683.2011.629069

Cited by 8 publications

(5 citation statements)

References 69 publications

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“… 6 Epidemiological studies have reported that AMD may be associated with genetics, family history, obesity, low education level, diet, history of cardiovascular and cerebrovascular disease, exposure to sunlight, and various other factors. 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 Possible associations between AMD and ocular factors such as light iris color, history of previous cataract surgery, short axial length, and hypermetropic refractive error have also been proposed. 15 , 16 However, there are inconsistencies among the literature data, and no studies have been conducted previously in the Turkish population.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Relationship Between Age-related Macular Degeneration and Refractive Error, Socio-demographic Features, and Biochemical Variables in a Turkish Population

Yurtseven¹,

Aksoy

Arsan

et al. 2018

tjo

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Objectives:To investigate the relationship between age-related macular degeneration (AMD) and refractive error and axial length, as well as the socio-demographic characteristics and biochemical variables that may affect this relationship.Materials and Methods:A total of 196 eyes of 98 patients over 50 years of age who were diagnosed with AMD at our clinic were included in this cross-sectional study. Early and late AMD findings were categorized according to the age-related eye disease study grading scale. Objective refractive error was measured by autorefractometer, confirmed by subjective examination, and spherical equivalent was calculated. Refractive errors of -0.50 D to 0.50 D were classified as emmetropia, <-0.50 D as myopia, and >0.50 D as hyperopia. Axial length was measured by ultrasonic biometry and values ≤23.00 mm were classified as short, >23.00 and <24.00 mm as normal, and ≥24.00 mm as long axial length. Demographic, systemic, and biochemical parameters of all patients were also investigated.Results:Hypermetropic refractive error and shorter axial length were significantly more common than the other groups (p<0.01). No differences were observed between early and late stage groups in terms of refractive error and axial length. Patients with myopia had significantly lower values for total cholesterol, triglyceride, fasting blood glucose, and proportion of smokers. Rates of oral nutritional supplement use and fish consumption were significantly higher in the early AMD group. The most common comorbidity among the AMD patients in our study was essential hypertension.Conclusion:Hyperopic refractive error and shorter axial length were found to be associated with AMD. Longitudinal studies including larger patient numbers are needed to elucidate the causal and temporal relationship between hyperopic refractive error and AMD.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the Relationship Between Age-related Macular Degeneration and Refractive Error, Socio-demographic Features, and Biochemical Variables in a Turkish Population

Yurtseven¹,

Aksoy

Arsan

et al. 2018

tjo

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“…It was established that prevalence of early AMD in the random sample was 7.3%, while in MI patients, it was 54.5% (p < 0.001). AMD increases more with age in females (3.7 and 10.8% at the age 45-54 and 55-64 years, p < 0.05, respectively) while in males, frequency of AMD did not differ significantly between latter age groups (9.9% vs. 11.6%; p > 0.05) [18]. Increased intake of fish reduced the risk of AMD, particularly for two or more servings per week.…”

Section: Risk Factors For Age-related Macular Degeneration Developmentmentioning

confidence: 80%

“…Higher systolic blood pressure, overweight and obesity, and physical exercise duration and frequency are associated with late AMD in women only [17]. The prevalence of AMD is significantly higher in patients with myocardial infarction (MI) than in a simple random sample of the population [18]. It was established that prevalence of early AMD in the random sample was 7.3%, while in MI patients, it was 54.5% (p < 0.001).…”

Section: Risk Factors For Age-related Macular Degeneration Developmentmentioning

confidence: 99%

Influence of Matrix Metalloproteinases MMP-2, -3 and on Age- Related Macular Degeneration Development

Liutkevičienė¹,

Liutkevičius²,

Giedraitienė³

et al. 2017

The Role of Matrix Metalloproteinase in Human Body Pathologies

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Age-related macular degeneration (AMD) is the leading cause of significant and irreversible central visual loss as it affects a small area of the retina, called the macula. However, the pathogenesis of still fairly understood. AMD has a multifactorial etiology, and its development might be influenced by body peculiarities, environmental and genetic factors. Risk factors such as age, gender, cigarette smoking, color of iris, nutrition, body mass index, oxidative stress, and genetic factors (complement factor H gene, Apo E gene, matrix metalloproteinases (MMPs) genes and others) increase probability to develop AMD. Here, we discuss about choroidal neovascularization process, where hypoxia, inflammatory process, and proteolytic enzymes play a main role, but mainly we focus on the family of matrix metalloproteinases (MMPs), especially on MMP-2,-3 and-9, and their impact on AMD development. MMPs belong to a family of proteolytic zinccontaining enzymes, and their mechanism under normal physiological conditions is precisely regulated, but when is dysregulated, MMPs become a cause of various diseases, including and AMD. MMPs are capable of degrading most of the extracellular matrix components, which are important in the remodeling during angiogenesis. Angiogenesis is the main pathological process associated with age-related macular degeneration development. Activated endothelial cells release MMPs which by degrading the basilar membrane allows capillaries to grow beneath the retina and retinal layers. Such capillaries often bleed, more liquids are filtered through the walls, and fibrous tissue grows within. Furthermore, swelling of the retina and impaired vision occur. In this book chapter, we focus on AMD prevalence, risk factors, clinics, diagnostics and influence of MMP-2,-3 and-9 on AMD development.

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“…Studies report the associations between CETP rs5882 and HDL‐C levels (Emamian et al, 2015) and Alzheimer‘s disease (Chen, Li, Zou, & Fu, 2014), which share the same pathological pathways as AMD (Xu, Cao, Rajapakse, & Matsubara, 2018). CETP rs708272 was shown to be associated with total cholesterol level changes (Iwanicka et al, 2018), with the risk of coronary atherosclerosis (Wang et al, 2013) and myocardial infarction (Semaev et al., 2019), which are linked to AMD as well (Liutkeviciene et al., 2012). CETP rs3764261 was also associated with serum HDL and APOA1 levels (Huang et al, 2019; Xu, 2019).…”

Section: Methodsmentioning

confidence: 99%

Association of genetic variants at CETP, AGER, and CYP4F2 locus with the risk of atrophic age‐related macular degeneration

Liutkevičienė

Vilkeviciute

Kriauciuniene

et al. 2020

Molec Gen & Gen Med

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Background Age‐related macular degeneration (AMD) is the leading cause of blindness in the elderly individuals. The etiology of AMD includes environmental and genetic factors. Methods We aimed to determine the association between CETP (rs5882; rs708272; rs3764261; rs1800775; rs2303790), AGER (rs1800624; rs1800625), and CYP4F2 (rs1558139) gene polymorphisms and development of atrophic AMD. About 52 patients with atrophic AMD and 800 healthy control subjects were evaluated. The genotyping of single‐nucleotide polymorphisms in CETP, AGER, and CYP4F2 was carried out using the real‐time‐PCR method. Results Genetic risk models in the analysis of CETP rs5882 revealed statistically significant variables with increased risk of atrophic AMD in the codominant (p < .001), dominant (p < .001), recessive (p < .001), and additive (p < .001) models with the highest 25.4‐fold increased risk of atrophic AMD in the codominant model (p < .001). The AGER rs1800625 was associated with a highly increased risk of atrophic AMD in the codominant (p < .001), recessive (p < .001), and additive (p < .001) genetic models. Conclusion We identified two polymorphisms with a higher risk of atrophic AMD (CETP rs5882 and AGER rs1800625).

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Early Age-Related Macular Degeneration in Patients with Myocardial Infarction

Abstract: We conclude that the prevalence of early AMD is significantly higher in patients with MI than in a random sample of the population.

Cited by 8 publications

References 69 publications

Evaluation of the Relationship Between Age-related Macular Degeneration and Refractive Error, Socio-demographic Features, and Biochemical Variables in a Turkish Population

Evaluation of the Relationship Between Age-related Macular Degeneration and Refractive Error, Socio-demographic Features, and Biochemical Variables in a Turkish Population

Influence of Matrix Metalloproteinases MMP-2, -3 and on Age- Related Macular Degeneration Development

Association of genetic variants at CETP, AGER, and CYP4F2 locus with the risk of atrophic age‐related macular degeneration

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