Early Amniocentesis at 10–12 Weeks' Gestation

Vega, M. Diaz; Cueva, Pablo de la; Leal, Caio Ribeiro Vieira; Aisa, F.

doi:10.1002/(sici)1097-0223(199604)16:4<307::aid-pd846>3.0.co;2-8

Cited by 12 publications

(1 citation statement)

References 24 publications

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“…Traditionally, amniocentesis is performed between gestational weeks 15-17 (Diaz-Vega et al, 1996). However, karyotyping is now possible in the first trimester of pregnancy by chorionic villus sampling or early amniocentesis (Diaz-Vega et al, 1996), and in the third trimester by late amniocentesis, placentocentesis or cordocentesis (Bree, 1979;Piroinen et al, 1984;Klein et al, 1981;Suchy and Yeager, 1993;Caspari et al, 1994;Boulot et al, 1992;Fisk et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Elective cytogenetic amniocentesis in the third trimester for pregnancies with high risk factors

et al. 1999

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The aim of the present study was to report the findings in 14 women with extremely high risk (‘precious’) pregnancies, 5 of whom had twins, who underwent elective third‐trimester cytogenetic amniocentesis. There were no procedure‐related complications, and all newborns weighed more than 2000 g and showed normal development. This practice is accepted under Israeli law and our institutional policy. This preliminary work does not attempt to answer the moral and ethical questions surrounding the use of third (versus second) trimester amniocentesis in either ‘precious’ or normal pregnancies. We do show, however, that the procedure is safe and may constitute a good alternative for patients who are unwilling to accept the risks of early fetal karyotyping. Copyright © 1999 John Wiley & Sons, Ltd.

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Section: Introductionmentioning

confidence: 99%

Elective cytogenetic amniocentesis in the third trimester for pregnancies with high risk factors

et al. 1999

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Trends in the use of prenatal diagnosis in New York State and the impact of biochemical screening on the detection of Down syndrome: 1984–1993

Olsen

Cross

1997

Prenat. Diagn.

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A study of early amniocentesis for prenatal cytogenetic diagnosis

Daniel

Ng²,

Kuah³

et al. 1998

Prenat. Diagn.

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A prospective pilot study for early amniocentesis was conducted over 4 years including 279 early amniocenteses (EAs at 10–14 weeks' gestation) and 181 mid‐trimester amniocenteses (MAs at 15 weeks upwards). The study was performed with EA and MA utilizing the same proceduralists, techniques, and cytogenetics laboratory. Patients were offered either procedure and the cytogenetics laboratory was not prospectively informed of the gestational age of each sampled pregnancy. In the early amniocenteses, less fluid was sampled and there were trends for (i) less cells and clones being available for analysis, less successful cultures, and a slightly longer reporting time; (ii) more multiple insertions (12·9 per cent of specimens vs. 9·9 per cent) and more bloody fluids (5·4 per cent specimens vs. 4·4 per cent); and (iii) a higher rate of pregnancy loss (2·2 per cent of EA vs. 0·6 per cent of MA). The multiple insertion rates for both EA and MA were comparatively high and were related to an increased frequency of blood‐stained fluids. For EA specimens, the rates of amniotic fluid leakage, preterm delivery, and pregnancy loss were moderate and not significantly increased over the MA group. This study adds more weight to the view that EA is a reasonably safe procedure and a reliable alternative to chorionic villus biopsy to provide early prenatal cytogenetic diagnosis. © 1998 John Wiley & Sons, Ltd.

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Early Amniocentesis at 10–12 Weeks' Gestation

Cited by 12 publications

References 24 publications

Elective cytogenetic amniocentesis in the third trimester for pregnancies with high risk factors

Elective cytogenetic amniocentesis in the third trimester for pregnancies with high risk factors

Trends in the use of prenatal diagnosis in New York State and the impact of biochemical screening on the detection of Down syndrome: 1984–1993

A study of early amniocentesis for prenatal cytogenetic diagnosis

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