Early Amygdala Reaction to Fear Spreading in Occipital, Temporal, and Frontal Cortex

Krolak‐Salmon, Pierre; Hénaff, Marie‐Anne; Vighetto, Alain; Bertrand, Olivier; Mauguı̀ere, François

doi:10.1016/s0896-6273(04)00264-8

Cited by 265 publications

(214 citation statements)

References 69 publications

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“…However, there is some debate on how such rapid perception is accomplished. A fast subcortical thalamus‐amygdala route bypassing the visual cortex is thought to transmit coarse face‐related information (LeDoux, 2009; Morris et al, 1998), but its role in face perception is controversial (Krolak‐Salmon et al, 2004; Pessoa & Adolphs, 2011), including whether it is fear‐specific (Méndez‐Bértolo et al, 2016) or non‐specific to expression (Garvert, Friston, Dolan, & Garrido, 2014; McFadyen et al, 2017). On the other hand, multiple fast cortical pathways forming part of a feedforward and feedback mechanism consistute an equally plausible mechanism for rapid expression perception (Liu & Ioannides, 2010; Pessoa & Adolphs, 2010).…”

Section: Introductionmentioning

confidence: 99%

Spatiotemporal dynamics in human visual cortex rapidly encode the emotional content of faces

Dima

Perry

Messaritaki

et al. 2018

Human Brain Mapping

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Recognizing emotion in faces is important in human interaction and survival, yet existing studies do not paint a consistent picture of the neural representation supporting this task. To address this, we collected magnetoencephalography (MEG) data while participants passively viewed happy, angry and neutral faces. Using time‐resolved decoding of sensor‐level data, we show that responses to angry faces can be discriminated from happy and neutral faces as early as 90 ms after stimulus onset and only 10 ms later than faces can be discriminated from scrambled stimuli, even in the absence of differences in evoked responses. Time‐resolved relevance patterns in source space track expression‐related information from the visual cortex (100 ms) to higher‐level temporal and frontal areas (200–500 ms). Together, our results point to a system optimised for rapid processing of emotional faces and preferentially tuned to threat, consistent with the important evolutionary role that such a system must have played in the development of human social interactions.

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Section: Introductionmentioning

confidence: 99%

Spatiotemporal dynamics in human visual cortex rapidly encode the emotional content of faces

Dima

Perry

Messaritaki

et al. 2018

Human Brain Mapping

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“…The role of the amygdala in fear perception and response was established through lesioning studies in animals and confirmed through positron emission tomography and functional magnetic resonance imaging in normal human subjects and in schizophrenic patients with deficits in fear processing (1)(2)(3)(4)(5)(6)(7)(8)(9).…”

mentioning

confidence: 99%

The dosage of the neuroD2 transcription factor regulates amygdala development and emotional learning

Lin

Hansen

Wang

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

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The amygdala is centrally involved in formation of emotional memory and response to fear or risk. We have demonstrated that the lateral and basolateral amygdala nuclei fail to form in neuroD2 null mice and neuroD2 heterozygotes have fewer neurons in this region. NeuroD2 heterozygous mice show profound deficits in emotional learning as assessed by fear conditioning. Unconditioned fear was also diminished in neuroD2 heterozygotes compared to wild-type controls. Several key molecular regulators of emotional learning were diminished in the brains of neuroD2 heterozygotes including Ulip1, ␣-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor, and GABA A receptor. Thus, neuroD2 is essential for amygdala development and genes involved in amygdala function are altered in neuroD2-deficient mice.basic helix-loop-helix ͉ haploinsufficiency T he amygdala is an almond-shaped brain structure that integrates emotional learning and other emotional responses such as fear perception. The role of the amygdala in fear perception and response was established through lesioning studies in animals and confirmed through positron emission tomography and functional magnetic resonance imaging in normal human subjects and in schizophrenic patients with deficits in fear processing (1-9).We previously reported that neuroD2-null mice on a mixed genetic background are indistinguishable from littermates at birth, but fail to thrive and die within weeks of birth. Before death, nullizygous mice develop ataxia, seizures, cerebellar degeneration, and growth retardation. NeuroD2 heterozygotes appear normal as adults, but have reduced seizure threshold and mild ataxia. We observed aggressive behavior between neuroD2 heterozygotes, which prompted us to evaluate the function and structure of the amygdala and related limbic system brain regions that control aggression, fear, and other emotions. Unconditioned fear (also referred to as anxiety or risk perception) is the response to environmental cues that signal danger. The basolateral amygdala and ventral subiculum of hippocampus are involved in unconditioned fear responses; however, the neuronal circuitry and molecular mechanisms are poorly understood (10).In contrast to unconditioned fear, the neurochemical and molecular basis of emotional learning related to conditioned fear are being elucidated through studies that evaluate fear conditioning in the context of pharmacologic or genetic manipulation of neurotransmitter receptors and second messengers. Fear conditioning involves coupling a neutral conditioned stimulus (CS) such as an audible tone with a noxious unconditioned stimulus (US) such as foot shock and observing that after training and rest periods, that the CS alone is sufficient to elicit behavioral (e.g., freezing) and autonomic responses (11,12). During the training and rest period, the lateral amygdala acquires and consolidates short-and long-term memory that associates the conditioned and unconditioned stimuli through a process known as emotional learning.The acquisition phas...

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“…Nous nous intéressons depuis peu à l'étude directe de la dynamique temporelle des réponses de l'amygdale à partir des signaux MEG, autrement accessible uniquement à partir d'enregistrements intra-cérébraux effectués dans un contexte préchirurgical chez des patients épileptiques [13]. Nous utilisons pour cela des méthodes de segmentation des structures du lobe temporal médian à partir des images IRM anatomiques individuelles [7].…”

Section: Une Détection Précoce ?unclassified

La détection cérébrale précoce des émotions

George¹

2011

Annales Médico-psychologiques, revue psychiatrique

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International audienceAu sens littéral, les émotions sont ce qui nous fait sortir de nous. Elles ont fondamentalement un versant somatique, en tant que réponses comportementales à des stimuli externes ou internes, et un versant psychique, en tant qu'expériences subjectives, ressenties par le sujet. La perception émotionnelle, c'est-à-dire la détection et l'évaluation du caractère émotionnel de stimuli, est caractérisée par des phénomènes de capture attentionnelle et d'amplification perceptive, qui peuvent aboutir à une détection consciente et un traitement accru des stimuli émotionnels. Les modèles actuels proposent que l'amygdale jouerait un rôle central dans la détection cérébrale précoce des émotions. Cet article présente les preuves en faveur de tels modèles, en développant particulièrement les études récentes relatives aux modulations émotionnelles des réponses cérébrales précoces aux stimuli visuels (C1 et P1) observées en électro et magnéto-encéphalographie (EEG-MEG)

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Early Amygdala Reaction to Fear Spreading in Occipital, Temporal, and Frontal Cortex

Cited by 265 publications

References 69 publications

Spatiotemporal dynamics in human visual cortex rapidly encode the emotional content of faces

Spatiotemporal dynamics in human visual cortex rapidly encode the emotional content of faces

The dosage of the neuroD2 transcription factor regulates amygdala development and emotional learning

La détection cérébrale précoce des émotions

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